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Fore Biotherapeutics

Fore Biotherapeutics is a Philadelphia-based, registration-stage precision oncology company developing targeted therapies for patients with hard-to-treat cancers. Its lead candidate, plixorafenib, is a next-generation BRAF inhibitor (a 'dimer breaker') aimed at BRAF-altered solid tumors, including BRAF V600E-mutated high-grade glioma, for which it received FDA Breakthrough Therapy Designation in 2026. Spun out of the Israeli functional-genomics company NovellusDx, Fore has raised more than $200M to push plixorafenib toward an accelerated FDA approval pathway.

~$91.5M cumulative priorEarlier rounds (incl. NovellusDx era)

precision oncologybiotechnologybraf inhibitorplixorafenibcancertargeted therapy