Duranium is a Y Combinator (S25) advanced-materials company reshoring U.S. production of critical metals - titanium, magnesium, aluminum, zirconium and hafnium. It modernizes carbochlorination metallurgy with a novel reactor that recirculates CO and chlorine streams back into feedstock and spins off a saleable co-product (bleaching agents/hypochlorite), aiming to match Chinese-level pricing without subsidies while eliminating direct emissions. Founded in 2025 by CEO Brenden Prins-McKinney and CTO Berkley Noble, the company targets a pilot facility by June 2026 and roughly 12% of the U.S. magnesium market by 2029.
Foundry Robotics is a San Francisco startup building 'The Everything Factory' - an AI-first, assembly-focused contract manufacturer that uses Vision-Language-Action (VLA) foundation models to run flexible robotic assembly cells. Instead of retooling a line for every new product, Foundry aims to let general-purpose robots switch between building drones, robot dogs, battery packs and satellite components on demand. Founded in 2025 by ex-Ghost Robotics and Scale AI robotics lead Adarsh Kulkarni, the company positions itself as a dual-use manufacturer serving both commercial customers and the U.S. Department of Defense, backed by a seed round led by Khosla Ventures and Garuda Ventures.
Laborup is a Knoxville, Tennessee startup building an AI-powered recruiting platform for America's skilled industrial workforce - the machinists, welders, and maintenance techs that keep factories running. Founded in 2024 by former Stanford AI researcher Tasimba 'Simba' Jonga, it uses voice-first AI agents to interview and profile blue-collar workers in minutes, then matches employers to a vetted network of thousands of tradespeople. The company pitches itself as the 'LinkedIn of manufacturing,' promising faster time-to-fill, lower cost-per-hire, and better retention, and has raised roughly $7.7M in total funding.
Brenden Prins-McKinney is the co-founder and CEO of Duranium (YC S25), an Alameda, California company working to bring critical light metal production - titanium, magnesium, aluminum, zirconium and hafnium - back to American soil. A Stanford Law graduate and Knight-Hennessy Scholar with a research background at McKinsey and a stint as a Goldman Sachs banker, he advised the Department of Defense on reshoring critical chemical production before deciding to build the supply chain himself. He pairs a policy-and-finance brain with chemistry borrowed from the 1950s, modernized so the U.S. can make metals it currently buys almost entirely from China and Russia.
James Crean is the co-founder and Chief Visionary Officer (also serving as President/CTO) of CREAN Inc, an Austin, Texas aerospace engineering and smart factory firm he started in 2002 with his wife Jennifer. A former satellite systems engineer and program manager at Hughes Space & Communications and Boeing - where he worked on DirecTV, NASA's TDRSS and other communications and weather satellites, and built the Lean Six Sigma group for Boeing Satellites - Crean now leads a team of 600-plus aerospace and defense engineers and champions CREAN's AI-enabled Smart Factory Operating System (SFOS), which aims to make American high-mix manufacturing fast, flexible and competitive enough to bring production home from overseas.
Build Block is a Korea-founded real estate company that gives Korean investors and companies a single, end-to-end path into the U.S. property market. What began as a cross-border investment platform lowering the barrier for individual Asian investors has grown into a full-stack operator: brokerage, architectural design and permitting, construction management as a general contractor, and post-investment asset and facility management. Today it also builds the physical backbone of the AI economy - data centers and EPC plants for semiconductor, battery, and advanced manufacturing - for Korean firms reshoring to the United States.
Seurat Technologies is a Massachusetts-based contract metal manufacturer built around Area Printing, a laser powder bed fusion process invented at Lawrence Livermore National Laboratory. Instead of melting metal powder one point at a time, Seurat uses millions of tiny laser points to print entire areas at once, decoupling resolution from speed. The company doesn't sell printers; it runs its own clean-energy print factories and sells finished parts at costs meant to rival casting, forging, and machining, with the goal of reshoring high-volume metal manufacturing and cutting its carbon footprint.
James DeMuth is the co-founder and CEO of Seurat Technologies, a Wilmington, Massachusetts metal additive manufacturing company chasing a single audacious goal: printing metal parts fast and cheap enough to compete with mass production, then planting factories next to the customers who need them. He co-invented Seurat's Area Printing technology while working on laser fusion research at Lawrence Livermore National Laboratory, holds a hand in roughly 145 patents, and has raised more than $181 million to reshore manufacturing and cut carbon out of how metal gets made.
Excelsior Sciences is a New York City biotech building 'machine-native chemistry' - a way to make small molecules that machines can execute and AI can learn from. Its proprietary smart bloccs platform turns drug synthesis into a modular, automation-friendly, iterative process, closing the loop between AI-driven discovery and real-world manufacturing. Founded in 2024 and spun out of Deerfield Management, the company raised $95M in late 2025 to scale the platform and reshore U.S. drug discovery and production.