Aleta Biotherapeutics is a Natick, Massachusetts immuno-oncology company building CAR T Engagers (CTEs) - simple biologic proteins that make existing CAR-T cell therapies work better. Its lead drug, ALETA-001, bridges a patient's CD19-targeted CAR T-cells to CD20 on cancer cells, aiming to rescue patients who relapse after standard CAR-T treatment for B-cell cancers. Founded in 2015 by Paul Rennert and Roy Lobb, the company is running a Phase 1/2 trial in the UK with Cancer Research UK and reported encouraging early data in December 2025.
Beacon Biosignals is a Boston-based neurotechnology company that pairs FDA-cleared wearable EEG hardware with AI to turn brain electrical activity - especially during sleep - into scalable, at-home neurodiagnostics. Its platform powers drug development, clinical trials, and precision medicine across neurology, psychiatry, and sleep medicine.
Curavit Clinical Research is a Boston-based, all-virtual Contract Research Organization (CRO) that designs and runs decentralized clinical trials. Through its Virtual Clinical Site and STRATUS platform, Curavit recruits, enrolls, and monitors diverse patient populations remotely - eliminating physical site infrastructure and travel while improving data quality. The company specializes in trials for digital therapeutics (DTx) and partners with sponsors and existing CROs to fix the execution layer of clinical research, accelerating timelines and lowering costs.
Anthony Costello is the CEO of Medidata Solutions, a Dassault Systèmes company, and one of clinical research technology's most seasoned architects. With nearly 30 years in the field, he started as a data manager at Genentech, co-founded two companies (Nextrials and Mytrus), and was acquired by Medidata before rising to lead it. Today he oversees over 8,000 active clinical studies globally each year, championing AI-driven trial innovation, decentralized models, and patient-centric design at the White House Clinical Trials Forum and beyond.
Bask Gill is the Co-Founder of Power (withpower.com), a San Francisco-based clinical trial platform that uses AI to match patients with clinical trials. After watching his father struggle to navigate a broken clinical trial discovery system following a multiple myeloma diagnosis, Bask co-founded Power in May 2021 alongside Brandon Li. The platform has connected over 600,000 patients to trials across 10,000+ medical conditions, with 40% being non-white patients - a deliberate focus on diversity and access. Power has raised $19M in funding including a $12M Series A in early 2024, and grown to 230 employees.
Celine Halioua is the founder and CEO of Loyal, a San Francisco biotech company developing the first FDA-approved drug for lifespan extension - starting with dogs. Born in Austin, Texas to a Moroccan mother and German father, she studied neuroscience at UT Austin and nanotechnology at Uppsala University before pursuing a DPhil at Oxford on the health economics of gene therapy. She left Oxford to join Laura Deming's Longevity Fund as Chief of Staff, then founded Loyal in 2019 at age 24. With $250M+ in total funding and the largest clinical trial ever conducted in animal health (1,300+ dogs across 70+ clinics), Loyal's lead drug LOY-002 has cleared FDA safety and efficacy hurdles - putting it on track to become the first longevity drug ever approved for any species.
Josh Rose is the CEO of Hawthorne Health, Inc. (formerly Hawthorne Effect), a Walnut Creek-based company building the largest community-based clinical trial site network in the U.S. A clinical research industry veteran with over 20 years of experience, Rose previously led decentralized clinical trial strategy at IQVIA and CVS Health before taking the helm at Hawthorne Health in early 2024. Under his leadership, Hawthorne has expanded to 75+ community locations, partnered with 40+ pharma sponsors, and pioneered a model that embeds certified clinical research staff inside independent pharmacies and patients' homes - bringing trials to communities that traditional research networks have long bypassed.
Power is a patient-first marketplace for clinical trials. The platform helps patients discover and enroll in promising research studies, while giving sites, sponsors, and CROs an AI-driven engine to accelerate recruitment across 30,000+ active U.S. trials and 10,000+ conditions.
Abdera Therapeutics is a precision oncology biotech engineering antibody-based radiopharmaceuticals that deliver therapeutic radioisotopes directly to tumor cells while sparing healthy tissue. Built around its proprietary ROVEr platform, the company is advancing ABD-147 in Phase 1 trials for small cell lung cancer and large cell neuroendocrine carcinoma, with a second program, ABD-320, on deck.
Kardigan is a South San Francisco heart health company modernizing cardiovascular drug development. Founded by the team behind MyoKardia, it pairs a late-stage clinical pipeline in dilated cardiomyopathy, acute severe hypertension and calcific aortic valve stenosis with a 'cardiac intelligence' platform - real-world patient data and AI - to match disease drivers to the right responders.
Frank D. Lee is the Chief Executive Officer and Board Director of Pacira BioSciences, a specialty pharmaceutical company pioneering non-opioid pain management solutions. A 30-year industry veteran who immigrated to the United States from South Korea, Lee built his career across Eli Lilly, Janssen, Novartis, and a 13-year tenure at Genentech where he oversaw $11 billion in global product sales. Before joining Pacira in January 2024, he led Forma Therapeutics through a transformative journey from drug-discovery startup to clinical-stage biotech, culminating in a $1.1 billion acquisition by Novo Nordisk in 2022. At Pacira, Lee is executing the '5x30' strategy - five bold objectives to transform the company into an innovative biopharma powerhouse by 2030, including advancing the PCRX-201 gene therapy for knee osteoarthritis, which has already earned FDA Regenerative Medicine Advanced Therapy (RMAT) designation.
Joe Belanoff is the co-founder and CEO of Corcept Therapeutics, a Redwood City-based biopharmaceutical company he has led since 1999. A physician-scientist trained at Amherst College, Columbia University, and Stanford, Belanoff pivoted from academia to entrepreneurship after co-developing intellectual property on cortisol modulation with Stanford psychiatry chair Alan Schatzberg. Under his leadership, Corcept achieved two landmark FDA approvals: Korlym in 2012 for Cushing's syndrome and Lifyorli in 2026 for platinum-resistant ovarian cancer - the first selective glucocorticoid receptor antagonist ever approved. He maintains an adjunct professorship at Stanford while steering a company with over $760 million in annual revenue and more than 30 ongoing clinical studies.
John McCutcheon is President, CEO, and Director of EBR Systems, Inc., the Sunnyvale-based medical device company behind the WiSE CRT system - the world's first FDA-approved leadless solution for left ventricular pacing. With over 40 years in medical device sales, marketing, and general management, McCutcheon has shepherded EBR through pivotal clinical trials, FDA Breakthrough Device Designation, and the landmark FDA approval in April 2025. Before EBR, he led Ceterix Orthopaedics to a $105 million acquisition by Smith & Nephew. He brings a track record of building and selling medical device companies, now steering EBR's commercial launch of a technology that could transform how heart failure patients receive cardiac resynchronization therapy.
Rami Elghandour is Chairman and CEO of Arcellx (NASDAQ: ACLX), a clinical-stage biotechnology company developing next-generation cell therapies for cancer and autoimmune diseases. An engineer turned venture capitalist turned serial CEO, he has led two successful IPOs, built two multibillion-dollar public companies, and raised over $1.75 billion in capital. At Arcellx, he transformed the company from an early-stage startup into a commercial-ready organization with a peak valuation exceeding $6 billion, advancing the anito-cel BCMA CAR-T therapy toward FDA approval for relapsed/refractory multiple myeloma. A TEDx speaker on unconscious bias and gender equity, Rami is also an executive producer of the Oscar-nominated documentary 'The Voice of Hind Rajab' and the Sundance-premiered 'American Doctor.'
Rick Winningham is the CEO of Theravance Biopharma, a biopharmaceutical company focused on organ-selective medicines for serious diseases including COPD, rare neurological conditions, and inflammatory diseases. With over 40 years in the pharmaceutical industry - including 13 years as CEO of Innoviva and 15 years at Bristol-Myers Squibb - Winningham has built a career defined by transformative drug development, strategic company leadership, and a widely recognized commitment to mentoring the next generation of biopharma executives, particularly women in leadership. He was named the 2026 HBA Honorable Mentor by the Healthcare Businesswomen's Association.
Steve Herne is the CEO of Unlearn.AI, a San Francisco-based company building AI-powered digital twin technology to transform how clinical trials are designed and run. With over 25 years of experience across pharmaceutical R&D companies including WCG, Bioclinica, and Covance, Herne joined Unlearn in May 2024 as Chief Commercial Officer before ascending to CEO in September 2024. Under his leadership, Unlearn — backed by $130M+ in venture funding including a $50M Series C led by Altimeter Capital — is pivoting from research-led to commercially-driven product delivery, with its digital twin models now EMA-qualified and adopted by major biopharma companies to reduce placebo arm sizes by up to 38% in pivotal trials.
Talat Imran is the CEO of Rani Therapeutics, a clinical-stage biotech company pioneering the RaniPill - a swallowable capsule that delivers injectable biologics painlessly through the intestinal wall. Son of prolific medical device inventor Mir Imran, Talat leads a company racing to replace needles with a pill, with applications spanning obesity, immunology, and rare disease. A computer scientist turned venture capitalist turned biotech CEO, he brings an unusual tech-meets-biology perspective to one of pharma's thorniest unsolved problems.
Eric Green is the Founder and CEO of Trace Neuroscience, a South San Francisco biotech company racing to develop the first effective ASO therapy for ALS. A Harvard-and-Stanford-trained physician-scientist with a background in cardiology, Green co-founded iLab Solutions (acquired by Agilent), Respira Design (Stanford $50K Challenge winner), and Maze Therapeutics before launching Trace with a $101 million Series A in November 2024. Trace's lead program targets UNC13A - a protein lost in ALS patients - using an antisense oligonucleotide designed to restore healthy nerve-muscle communication. With clinical trials targeting early 2026, Green is betting human genetics can do for ALS what it did for heart failure.
Josh Lehrer is a physician-scientist and biotech executive serving as CEO of Marea Therapeutics, a clinical-stage company harnessing human genetics to develop first-in-class medicines for cardiometabolic diseases. A cardiologist by training with degrees from Harvard, Cambridge, and UCSF, Lehrer brings over two decades of drug development experience spanning Genentech, Global Blood Therapeutics (where he oversaw the FDA approval of Oxbryta for sickle cell disease), and Graphite Bio. At Marea, he has led the company from a Third Rock Ventures incubation to a $190 million-funded enterprise with two clinical-stage programs showing strong early efficacy data, including a 53% reduction in remnant cholesterol with MAR001 published in The Lancet.
Supreet Deshpande is Co-Founder and CEO of Synthio Labs, a Y Combinator-backed startup building clinical-grade voice AI for the life sciences industry. Drawing on his experience leading Gen AI for Life Sciences at McKinsey and analytics work at ZS Associates and JPMorgan Chase, Deshpande is solving a stubborn pharma problem: 70% of physicians never hear from a field team despite billions spent. Synthio's AI voice agents - reaching every clinician and patient with compliant, multilingual, FDA-aligned conversations - raised a $5M seed round led by Elevation Capital in November 2025 and already counts several Top 10 pharma companies as customers.
Adam Rosenthal is the CEO and Founder of Star Therapeutics, a clinical-stage biotech he launched in 2018 with a mission to develop life-changing therapies for rare diseases. An MIT and Harvard-trained biomedical engineer, Rosenthal built Star around the insight that shared biology across multiple rare diseases can yield single therapies addressing many conditions at once. His lead asset VGA039 - a first-in-class monoclonal antibody targeting Protein S - entered Phase 3 trials in 2025 for von Willebrand disease, the most common inherited bleeding disorder. Star has raised over $315 million from top-tier life sciences investors including Sanofi Ventures and Viking Global Investors.
Diana Peng Bockus is the Chief Executive Officer of NGM Biopharmaceuticals, a South San Francisco biotech developing first-in-class medicines for liver disease, oncology, and ophthalmology. Appointed CEO in April 2025, she joined the company in 2020 to lead business development and restructured a pivotal Merck partnership that freed NGM to build a wholly owned pipeline. A Stanford and Wharton graduate with roots in management consulting at Bain & Company, she now steers a privately held biotech backed by $515M in total funding, focused on rare diseases like primary sclerosing cholangitis and hyperemesis gravidarum.
Mike Novotny is the founder and CEO of Medrio, a San Francisco-based eClinical SaaS company he started in his apartment in 2005. Over 15 years he bootstrapped Medrio into a nine-figure company that has helped customers win regulatory approvals for more than 100 treatments. After a sabbatical researching organizational development, he returned as CEO in 2025, betting that AI will reshape clinical trial data management. Before Medrio, he was CEO of Telosa, President of Ninaza, a UN research associate, and managed the fraud database at Visa. He holds degrees from Stanford, PUC Chile, and Columbia.
Scott Clarke is the CEO of CatalYm GmbH, a Munich-based biotech company developing visugromab, a monoclonal antibody targeting GDF-15 to reverse cancer immunotherapy resistance. With over 20 years in biopharmaceuticals - spanning Roche's global oncology partnering, BioMarin, Tizona Therapeutics, and Ambagon Therapeutics - Clarke joined CatalYm in January 2025 to lead the company's $319M-funded push through Phase 2b clinical trials, building on visugromab's striking Phase 1/2a results published in Nature showing durable responses lasting 28-32+ months in multiple solid tumor types.
Tassos Gianakakos is a Greek-American biotech entrepreneur and the co-founder, CEO, and Chair of Kardigan, a cardiovascular drug discovery company he built from the ashes of MyoKardia — the precision-medicine heart company he led to a $13.1 billion acquisition by Bristol Myers Squibb in 2020. At Kardigan, he is applying the same playbook: marrying real-world clinical data, AI tools, and deep cardiovascular biology to deliver personalized medicines for heart disease — a field he believes is where oncology was 20 years ago. With $554 million raised and three late-stage clinical programs underway, Gianakakos is on a mission to make cardiovascular disease preventable and curable.
Mark Lee, MD, PhD is the CEO and Co-Founder of N-Power Medicine, a Redwood City-based company reinventing how oncology clinical trials reach patients. A medical oncologist and scientist trained at Stanford and Harvard, Lee has spent his career at the frontier of personalized medicine - from developing Oncotype DX diagnostics at Genomic Health, to helping build early cancer detection at GRAIL, to leading personalized healthcare at Genentech/Roche. In 2021, he co-founded N-Power Medicine to embed research infrastructure directly into community oncology clinics, combining AI, embedded staff, and real-time registries to dramatically expand clinical trial access. After raising a $72M Series B led by Merck's Global Health Innovation Fund, N-Power acquired Syapse in late 2024 to build the largest community-based prospective clinical research network in oncology.
Nikhil Krishnan is the founder and 'Thinkboi' behind Out-of-Pocket, a healthcare newsletter and education platform that makes the bewildering business of American healthcare funny, accessible, and actually worth reading. A Brooklyn-based writer, creator, and early-stage investor, Krishnan grew up in a family of physicians and parlayed a career in healthcare research at CB Insights and clinical trial partnerships at TrialSpark into one of the most original media brands in health tech - one that includes a newsletter with 30,000+ subscribers, educational crash courses, a medical bankruptcy card game, a children's book about clinical trials, hackathons, and a scout fund backing early-stage healthcare startups.