Daniel Amen built a national clinic network around the promise of seeing the brain. The appeal is easy to understand. The argument over what those pictures prove is harder to settle.
FSA Store turned the confusion around tax-free health benefits into a shopping business. Now its parent company is moving from the medicine cabinet into virtual care.

Before virtual care became ordinary, Henry DePhillips was arguing that convenience still needed clinical discipline. His career traces healthcare's long migration from the exam room to the screen, and from the screen to the spreadsheet.
The company began with a medical office manager who was fed up with clumsy billing software. Twenty-five years later, its single-database bet runs the daily machinery of 13,000 practices - and reveals both the appeal and the cost of buying the whole stack.
The company that taught dieters to examine their habits is now prescribing medicine, scanning faces and mailing blood-test kits. Its second reinvention asks whether behavior change can remain the product when the drug works faster.
Qualifacts assembled three EHRs for three different kinds of behavioral-health provider. Now it is using AI, interoperability, and targeted acquisitions to turn that portfolio into something closer to an operating system for care.
Valant spent two decades turning one psychiatrist’s frustration with generic software into an operating system for behavioral-health practices. Its advantage is specialization - and its history shows the cost of wandering away from it.
Maven’s first consumer clinic arrived before patients were ready. Employers funded the long detour - and 28 million covered lives later, the company is reopening the front door with a broader bet on women’s health.
Hospitals bought telehealth cameras during the pandemic. Caregility is trying to turn that hardware into a new labor model - one virtual nurse, many rooms, and fewer clerical miles for the people at the bedside.

For decades, the physician executive moved between clinical practice, corporate operations and public policy - turning frontline judgment into programs built to work at scale.
For decades, MHN sat between an insurance card and a therapist's door. Then Health Net moved much of the machinery under its own name - a case study in what happens when a useful company becomes infrastructure.

The Plume co-founder took a scenic route through art, athletics, public service, medicine and startups. The thread connecting it all is a stubborn belief that systems should be designed around the people who actually use them.

The Iris Telehealth CEO has spent a career turning technology into ordinary infrastructure. The idea at its center is simple: virtual care wins when nobody has to call it virtual anymore.

A social worker, a school clinician and a string of 7 a.m. Panera meetings became AnswersNow. Jeff Beck's useful obsession is turning scarce expertise into support families can actually reach.

Before she built a company, Sandra Abrevaya learned how power actually moves - through campaigns, coalitions, city halls and the stubborn work of getting people into the same room.

A product operator and a speech therapist built Expressable around a stubborn idea: progress depends on what happens between appointments. Nicholas Barbara's job has been turning that insight into a company that can travel.

The ROMTech co-founder built his playbook around unglamorous things: listening closely, testing early, raising patiently and knowing when more revenue is the wrong answer.

The Philadelphia nurse-turned-founder built a company from questions nobody owned - then learned that the durable kind of growth begins when you stop confusing motion with progress.

She took lessons from media, education and one stubborn Miami launch, then built a national company around an unfashionable question: who gets left out when convenience becomes the product?

An electrical engineer learned to see access as a systems problem. Now he and co-founder Amy Fan are turning an unfashionable constraint - serving people commonly ignored by digital care - into Twentyeight Health's operating design.

The Vytal Health founder traded a large health system for the unruly work of building a company - and made the unscalable act of listening the center of its model.
The Korean-American health startup began by putting doctors on a screen. Its more revealing move was opening doors in Manhattan, New Jersey and inside major employers - a hybrid-care playbook built around access, continuity and the stubborn usefulness of a room.
The Miami platform began as a marketplace for Spanish-speaking therapists. Its sharper insight - that migration, family and identity shape care - turned cultural fluency into a five-stage subscription business.
Most fertility businesses sell a treatment after something goes wrong. Onto Health is trying to sell clarity earlier - then use clinics, software and a $20 million Series A to carry patients through what comes next.
Carenet’s bet is that the most expensive gap in American healthcare is often a missed call, a confusing benefit or an appointment never booked. It sells the people, software and clinical workflows to close that gap - at a scale that now reaches one in three Americans.
The Danish-founded health company built a weight-care business around an unfashionable proposition: the expensive drug should be a temporary tool, not the entire product. Its next test is whether a 2,694-person real-world study can persuade American benefits buyers.
For decades a clinical trial meant a patient driving to a site. THREAD bet the visit could come to them instead - and then bought four companies to prove it.
A failed family video call became a contrarian product brief: fewer choices, no passwords and a human on call. GrandPad shows what happens when accessibility is treated as the whole business, not a settings menu.
A family tragedy sent two founders after one of medicine's most subjective rituals. Their bet: short phone tests can make the months between neurology visits visible - if patients, doctors and drug developers trust the measurements.
The Milwaukee telehealth practice asks patients to pay outside insurance for time, continuity and deeper testing. Its early obstacle was convincing people that a video visit could still feel human; its sharper 2026 answer is a two-tier membership with unusually clear boundaries.