Treeline Biosciences is a Watertown, Massachusetts biotech founded in 2021 by Loxo Oncology founder Josh Bilenker and former Novartis oncology head Jeff Engelman. It pairs in-house wet-lab R&D with leading-edge computational tools to invent cancer medicines reliably and repeatedly, choosing targets by what the technology can reach rather than by therapeutic fashion. After operating largely in stealth, Treeline has raised more than $1.1 billion and moved three programs - a BCL6 degrader, a pan-KRAS inhibitor, and an EZH2 inhibitor - into Phase 1 trials. In June 2026 it agreed to go public through an all-stock reverse merger with Standard BioTools, with the combined company set to trade on Nasdaq as 'TRLN'.
Zag Bio is a Cambridge, Massachusetts biotechnology startup pioneering thymus-targeted medicines for autoimmune disease. Founded and incubated by Polaris Partners and launched in October 2025 with an $80M Series A, the company designs bifunctional antibodies that ferry self-antigens directly into the thymus - the organ that trains immune cells - to re-teach the body to tolerate its own tissue rather than attack it. Its lead program, ZAG-101, aims to prevent or delay Type 1 diabetes by inducing durable, antigen-specific central tolerance instead of broad immunosuppression.
one.bio is a Sacramento biotechnology company that releases short-chain plant fibers and makes them flavorless, odorless, colorless and water-soluble so they can be added to food and drinks at high doses without changing taste or texture. Spun out of UC Davis, it pairs a fiber-mapping knowledgebase called the Glycopedia with a proprietary depolymerization process to turn long-chain plant carbohydrates - including agricultural byproducts - into bioactive fibers that feed the microbiome and support metabolic and immune health. The company raised a $27M Series A in December 2024 and in early 2026 launched its discovery platform, its first clinically validated ingredient (one.bio 01) and a consumer brand, GoodVice.
Paul Singer is the cofounder and CEO of FleetWorks, a San Francisco startup building always-on voice AI agents that handle the phone-and-email grind of freight brokerage. A former Uber Freight product manager and Yale economics grad, he started FleetWorks in late 2022 with cofounder Quang Tran, went through Y Combinator's Summer 2023 batch, and in October 2025 raised a $17M round (including a $15M Series A led by First Round Capital) to automate the matching of trucks with cargo across a $1T+ industry.
Calluna Pharma is an Oslo-based clinical-stage biotech building first-in-class antibodies that switch off the upstream signals driving inflammation and fibrosis. Formed in 2024 from the merger of Oxitope Pharma and Arxx Therapeutics and backed by a EUR 75 million Series A, the company targets damage-associated molecular patterns (DAMPs) such as S100A4 to halt diseases like idiopathic pulmonary fibrosis at their root rather than managing symptoms.
dub is America's first regulated copy-trading platform, letting everyday investors mirror the portfolios of top traders, hedge-fund managers, and even politicians with a single tap. Founded by 23-year-old Harvard dropout Steven Wang and headquartered in New York, the SEC-registered, FINRA-member, SIPC-insured app has surpassed 1 million downloads and raised $47M total, including a $30M Series A in May 2025 co-led by Notable Capital and Neo.
Hinge Bio is a clinical-stage biotechnology company in Burlingame, California, building next-generation antibody therapeutics on its proprietary GEM-DIMER platform. The platform engineers multivalent, multispecific antibodies that bind their targets cooperatively for dramatically enhanced potency. Its lead candidate, HB2198, is a B cell-depleting agent targeting both CD19 and CD20 with enhanced natural killer cell engagement, now in Phase 1 trials for systemic lupus erythematosus and lupus nephritis. The company raised a $30M Series A led by Point72 in January 2025.
Leal Therapeutics is a Worcester, Massachusetts biotech founded in 2021 by repeat CNS entrepreneur Asa Abeliovich, the scientist behind Prevail Therapeutics (acquired by Eli Lilly). Leal builds first-in-class neuro-metabolic medicines on a single idea: many brain diseases share a broken metabolism, and correcting those imbalances can treat conditions from schizophrenia to ALS. Backed by roughly $114M in total funding, its pipeline includes LTX-001, a brain-penetrant oral glutaminase inhibitor in the clinic, and LTX-002, an antisense oligonucleotide for ALS.
Myricx Bio is a London-based oncology biotech developing a completely new class of payloads for antibody-drug conjugates (ADCs), built on inhibitors of N-myristoyltransferase (NMT). Spun out of Imperial College London and the Francis Crick Institute, the company aims to give ADCs a fresh way to kill cancer cells that resist today's standard payloads. In July 2024 it closed a £90m ($114m) Series A, one of Europe's largest biotech rounds that year, to push its NMTi-ADC pipeline toward clinical trials.
Ryan Janssen is the Co-founder and CEO of Zenlytic, a New York-based AI-powered business intelligence platform that lets non-technical users query data in plain English. A former McKinsey consultant and 6-year venture capital investor with advanced degrees from Harvard and Oxford, Ryan co-founded Zenlytic in 2020 alongside CTO Paul Blankley after spotting a gap: companies had modern data infrastructure but no accessible way to use it. Zenlytic has raised $15.4M including a $9M Series A in 2024 led by M13, and its AI analyst Zoe can now onboard itself autonomously to any data warehouse.
Sage Wohns is the CEO and Co-Founder of Jericho Security, a New York-based AI cybersecurity company that trains humans and AI systems to defend against AI-powered attacks including hyper-realistic phishing, deepfakes, and voice cloning. A Seattle native and 10-year AI industry veteran, Wohns previously built and led Agolo, a Google- and Microsoft-backed NLP summarization company, before co-founding Jericho Security in 2023. The company made history by winning the Pentagon's first-ever generative AI defense contract through AFWERX in December 2023, and has since raised $18M in total funding, including a $15M Series A in April 2025. With 39 employees and 30+ enterprise clients, Jericho Security is at the frontier of AI-versus-AI cyber defense.
Sahil Hasan is the CEO and Co-Founder of Dots, a developer-friendly global payouts platform that has processed over $1 billion to more than 1 million gig workers, creators, and contractors in 190+ countries. A UC Berkeley EECS grad with a CMU master's degree, Sahil spent time as a Research Engineer at Google X before co-founding Dots through Y Combinator's S21 batch. The company raised an $8.9M Series A in February 2026 led by DCM Ventures, is profitable, and growing revenue 400% year-over-year.
Maite Muniz Telleria is the Co-Founder and Chief Product Officer of Truora Inc., a San Francisco- and Colombia-based startup that helps Latin American businesses verify identities, run background checks, and automate customer engagement via WhatsApp. A former McKinsey consultant turned startup builder, she left corporate strategy to co-found Truora in 2018 alongside Daniel Bilbao, David Cuadrado, and Cesar Pino. Under her product leadership, Truora scaled from a single-country MVP to a multi-country platform serving clients like Bancolombia, Didi, Mercado Libre, and Rappi, raising $15M in a Series A led by Accel and BBVA's Propel fund in 2022. Maite is also an angel investor focused on women-led ventures and a board member of The F Code.
Ceremorphic is a San Jose-based fabless semiconductor startup building energy-efficient AI supercomputing silicon. Founded in 2020 by serial entrepreneur Venkat Mattela, the company taped out a first-of-its-kind 5nm HPC/AI chip on TSMC's most advanced node and is applying the same Hierarchical Learning Processor architecture to data center AI, robotics, automotive, and analog-AI-driven drug discovery.
ChangeEngine is a San Francisco-based AI-powered employee experience platform that helps People teams design, automate and personalize internal communications across the entire employee lifecycle - from onboarding to recognition - across email, Slack, Teams, SMS and SharePoint, without forcing employees to log in to a new tool.
Chef Robotics builds AI-powered robotic arms that assemble meals in food production plants. Its ChefOS platform powers Robotics-as-a-Service deployments at customers like Amy's Kitchen, Sunbasket, Chef Bombay, and Cafe Spice, having helped produce 70+ million servings across North America.
Ema builds a 'Universal AI Employee' for the enterprise - autonomous AI agents that plug into existing systems and run business processes across customer support, sales, HR, finance, and compliance. Founded in 2023 by ex-Coinbase CPO Surojit Chatterjee and ex-Okta engineering VP Souvik Sen, the company is headquartered in San Francisco and has raised $61M to date.
Glow is a San Francisco insurtech rebuilding workers' compensation insurance for small businesses. Founded in 2018 by Samad Wahedi, the company combines a digital platform, payroll-integrated pay-as-you-go billing, and a concierge claims experience to give the people who run America's small businesses coverage that's faster to buy, fairer to price, and friendlier to use.
Higgsfield AI is a San Francisco-based generative AI company that builds professional video and image creation tools for creators, marketers, and enterprise teams. Founded in October 2023 by former Snap executive Alex Mashrabov, the platform offers Cinema Studio, Lip-Sync Studio, and a suite of AI models (Sora 2, Kling 3.0, Veo 3.1) for producing cinematic-quality content. The company reached $200M annualized revenue run rate within 9 months of launch, achieved unicorn status at a $1.3B valuation in January 2026 after raising $80M in a Series A extension led by Accel, and hosts 25 million users across 240+ countries generating 4.5 million videos per day.
Hourly is a Palo Alto-based fintech platform that combines payroll, workers' compensation insurance, and time tracking into a single mobile-first system built for small businesses with hourly workers. Its pay-as-you-go workers' comp model calculates premiums against actual wages in real time, eliminating year-end audits and helping employers avoid overpaying. Founded in 2018 by Tom Sagi, Shay Litvak, and Amir Faintuch, the company raised $39M+ and serves 500+ businesses across construction, manufacturing, transportation, and similar industries. In July 2025, Hourly was acquired by Israeli insurtech WeSure in a deal valued at approximately $168M.
Humand is a mobile-first, all-in-one HR platform built for the 2.7 billion deskless and frontline workers who have never had a proper digital work home. Founded in 2020 by Nicolas Benenzon and Geronimo Maspero, the platform combines 30+ HR modules - from internal communications and payroll to performance reviews and AI-powered automation - into a single app. With 1.6 million workers across 1,500+ organizations in 51 countries, and a $66M Series A raised in February 2026 co-led by Kaszek and Goodwater Capital, Humand is positioning itself as the operating system for the world's largest workforce segment.
InfrasAI (formerly iLife Technologies) is a Sunnyvale-based AI infrastructure company that builds the plumbing behind modern insurance distribution. Their headless API platform lets insurance carriers connect to any distributor channel - agents, brokers, IMOs - without rebuilding integrations from scratch each time. The core bet: use agentic AI to auto-generate workflows from natural language, collapsing integration timelines from 24 weeks to about 2. Customers include Transamerica and Guardian Insurance. Backed by Foundation Capital, Brewer Lane Ventures, SCOR, and others, InfrasAI has raised $28M total.
Lumber is an AI-powered construction workforce management platform that unifies payroll, time tracking, HR, safety, compliance, and field productivity for contractors. Founded in 2023 by Shreesha Ramdas and Manish Kumar, the company is building autonomous AI agents for an industry where 41% of the workforce is set to retire in seven years.
Opya is a California-based early intervention therapy provider specializing in comprehensive, multidisciplinary care for children aged 18 months to 6 years diagnosed with autism. The company delivers Applied Behavior Analysis (ABA), speech therapy, occupational therapy, and feeding therapy through in-home, clinic-based, and telehealth models across Northern and Southern California. Backed by $34.7M in total funding including a $15.4M Series A in 2021 from investors including SoftBank's SB Opportunity Fund, Opya is one of only eight ABA providers in California to hold BHCOE (Behavioral Health Center of Excellence) accreditation. In 2024, the company expanded into center-based care through the acquisition of Center for Autism Spectrum Therapy (CAST) and began operating under the Spectrum Pride brand.
Abel Mengistu is the cofounder and CEO of FlutterFlow, the low-code visual app builder that has enabled over 2 million users to create production-ready Flutter applications without deep coding expertise. A former Google senior software engineer who worked on Google Maps and ATAP hardware, he co-founded FlutterFlow in 2020 with Alex Greaves after a failed restaurant-recommendation startup taught them the real bottleneck was app development complexity. Accepted into Y Combinator's Winter 2021 batch after applying past the deadline, they famously survived 'No-sleep November' to build FlutterFlow 1.0 in a single month. The company raised a $25.5M Series A from GV (Google Ventures) in January 2024, has grown to 173 employees, and in 2025 launched Dreamflow - an AI-powered builder that generates production-ready app screens in roughly 10 seconds.
Abhishek Choudhary is the Co-Founder and CTO of TrueFoundry, a Series A-backed AI infrastructure platform that helps enterprises deploy, manage, and govern machine learning models at scale. A former Senior Staff Engineer at Meta — where he worked on infrastructure serving over a billion users — he left to build the platform he wished had existed at Facebook: one that brings Meta-level AI automation to every enterprise. An IIT Kharagpur alumnus, he co-founded TrueFoundry in 2021 alongside batchmates Nikunj Bajaj and Anuraag Gupta, and has since grown it to serve clients like NVIDIA, Siemens Healthineers, and ResMed, raising $21.3M in total funding.
Abhishek Humbad is the Founder & CEO of Goodera, the world's largest corporate volunteering platform, connecting 500+ enterprises - including 75+ Fortune 500 companies like Amazon, Nike, Oracle, and Target - with 50,000+ nonprofits across 100+ countries. A BITS Pilani and IIM Bangalore alumnus and Forbes 30 Under 30 honoree, Humbad co-founded Goodera in 2014 after pioneering NextGen, India's first cloud-based CSR management platform. Under his leadership, Goodera has mobilized 2 million+ volunteers across 1,000+ cities in 30+ languages, raised $26M+ in funding, and now deploys an AI Ops Brain managing 100,000+ tasks monthly - treating volunteering not as a charity checkbox, but as infrastructure for workplace belonging.
Abhishek Jha is the Co-Founder and CEO of Elucidata, a San Francisco-based AI company making biomedical data AI-ready for drug discovery and pharmaceutical R&D. A trained physical chemist with a PhD from the University of Chicago and postdoctoral work at MIT, he spent years at Agios Pharmaceuticals contributing to four FDA-approved first-in-class therapies before co-founding Elucidata in 2015. Under his leadership, the company has raised over $22.7M in funding, grown to 170 employees, and achieved $22.2M ARR, while evolving from a data-curation platform into an AI company solving out-of-distribution (OOD) problems in biomedical research - work that earned Elucidata recognition as one of Fast Company's Most Innovative Companies in 2024.
Akash Agarwal is the Founder and CEO of Pibit.AI, a Y Combinator-backed insurtech company revolutionizing commercial insurance underwriting through AI. Building on a childhood watching his father toil as an insurance agent buried in paperwork, Akash set out to automate the most labor-intensive parts of underwriting. Pibit.AI's CURE platform - Centralized Underwriting Risk Environment - processes loss runs, submission documents, and risk data at machine speed, helping insurers cut underwriting cycle times by up to 85% and improve loss ratios by up to 700 basis points. After raising a $7M Series A led by Stellaris Venture Partners in November 2025, with participation from Y Combinator and Arali Ventures, the company is scaling its AI models and data partnerships to reshape how the $1T+ P&C insurance industry makes risk decisions.
Alex Greaves is the Co-Founder and CTO of FlutterFlow, a visual low-code/AI-powered app development platform he co-founded in 2020 alongside fellow ex-Googler Abel Mengistu. Built on Google's Flutter framework, FlutterFlow has grown to serve over 2 million users across 200+ countries, backed by $25.5M in Series A funding led by GV and Gradient Ventures at a ~$170M valuation. A Stanford physics and CS grad who honed his craft on Google Maps' machine learning team, Greaves now leads a platform that lets developers and non-developers alike ship native iOS, Android, and web apps in a fraction of traditional development time.