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Tagged: fibrosis
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Executive · Operator · Investor
Kevin Walton
Kevin Walton is the Chief Executive Officer and Board Director of Baseimmune, a London-based biotech using AI and computational protein design to build next-generation vaccines and active immunotherapies. He joined in 2024 after a career in biotech corporate development and dealmaking at Moderna, StrideBio, Curis and G1 Therapeutics, and is steering the company beyond infectious-disease vaccines into chronic diseases, starting with a lead fibrosis program in idiopathic pulmonary fibrosis.
kevin walton · baseimmuneRead →
Founder · Scientist · Executive
Adam Freund
Adam Freund is the founder and CEO of Arda Therapeutics, a San Carlos biotech built on a simple, contrarian bet: many chronic diseases are caused by specific cells gone wrong, so the cure is to find and delete those cells while leaving healthy tissue intact. A molecular biologist with a Berkeley PhD and a Stanford postdoc, he spent seven years at Google-backed Calico Life Sciences, where he helped grow the company from roughly 15 to 200-plus people and started its most advanced anti-aging therapeutic program. In late 2021 he left to start Arda as a solo founder with a deck and a thesis, and by October 2024 had raised a $43M Series A led by a16z Bio + Health. His tools are single-cell sequencing to map disease cell-by-cell and antibodies to do the deleting.
adam freund · arda therapeuticsRead →
Executive · Operator · Scientist
Aditya Venugopal
Aditya Venugopal is the Chief Business Officer of Alentis Therapeutics, a clinical-stage Swiss biotech chasing first-in-class therapies aimed at claudin-1 for fibrosis and cancer. An immunologist turned dealmaker, he spent 15-plus years moving between the lab bench and the negotiating table: a Ph.D. in immunology from Weill Cornell, seven years in strategic life-science consulting, then senior roles at Intercept, VectivBio and Versanis Bio. He has a habit of being in the room when companies get acquired - VectivBio went to Ironwood, Versanis went to Eli Lilly - and he reunited with CEO Mark Pruzanski at Alentis after first partnering with him at Intercept.
aditya venugopal · alentis therapeuticsRead →
Health · Vc · Enterprise
Alentis Therapeutics
Alentis Therapeutics is a Swiss clinical-stage biotech built around a single, unusual biological target: Claudin-1 (CLDN1), a tight-junction protein that becomes exposed in both fibrotic tissue and solid tumors. Founded in 2019 on the discovery of physician-scientist Professor Thomas Baumert, the company develops first-in-class monoclonal antibodies and antibody-drug conjugates that bind exposed CLDN1 to reverse organ fibrosis and treat CLDN1-positive cancers. Headquartered in Allschwil near Basel with R&D roots in Strasbourg, Alentis has raised roughly $365 million across rounds, including a $181.4 million Series D in November 2024, and is running clinical trials for its lead antibody lixudebart (ALE.F02) and two ADCs, ALE.P02 and ALE.P03.
biotech · claudin-1Read →
Health · Ai
Arda Therapeutics
Arda Therapeutics is a San Carlos, California biotech building precision biologics that eliminate the specific cells driving chronic disease rather than tinkering with the proteins those cells produce. Using a single-cell data discovery engine, Arda maps disease-specific cell states, pinpoints their surface markers, and designs targeted therapies that deplete only the harmful cells while sparing healthy tissue. Founded in 2021 by former Calico scientist Adam Freund, the company is applying lessons from oncology to fibrosis, autoimmune, and metabolic disease, backed by a $43M Series A led by a16z Bio + Health.
biotechnology · targeted cell depletionRead →
Health
Epirium Bio
Epirium Bio is a San Diego-based clinical-stage biopharmaceutical company developing orally available small molecules that target PGE2 signaling to restore tissue homeostasis, reduce inflammation, and stimulate regeneration. Its lead candidate, MF-300, is a first-in-class oral 15-PGDH enzyme inhibitor advancing toward a Phase 2b trial for sarcopenia, the age-related loss of muscle strength for which no FDA-approved therapy currently exists.
biotech · biopharmaceuticalRead →
Health · Ai · Enterprise
HAYA Therapeutics
HAYA Therapeutics is a clinical-stage precision medicines company spun out of Lausanne University Hospital (CHUV) in 2019. It develops RNA-guided programmable therapeutics that target long non-coding RNAs in the so-called 'dark genome' - the roughly 98% of human DNA that does not code for proteins - to reprogram disease-driving cell states. Its lead candidate, HTX-001, is an antisense oligonucleotide targeting the cardiac lncRNA Wisper for heart failure, with a broader pipeline spanning fibrosis, metabolic disease and cancer. The company is headquartered in Lausanne, Switzerland, with US laboratory operations in San Diego, and raised a $65M Series A in May 2025.
lncrna · long non-coding rnaRead →
Health · Ai · Enterprise
Mirador Therapeutics
Mirador Therapeutics is a San Diego precision-medicine company building first- and best-in-class therapies for immune-mediated inflammatory and fibrotic diseases. Its Mirador360 engine fuses human genetics, multi-modal patient data, AI and advanced analytics to find novel targets, design combination therapies and identify the patients most likely to respond. Founded in 2024 by the former Prometheus Biosciences leadership team, Mirador launched with more than $400 million and has since raised over $650 million total.
biotech · precision-medicineRead →
Health · Ai · Enterprise
Calluna Pharma
Calluna Pharma is an Oslo-based clinical-stage biotech building first-in-class antibodies that switch off the upstream signals driving inflammation and fibrosis. Formed in 2024 from the merger of Oxitope Pharma and Arxx Therapeutics and backed by a EUR 75 million Series A, the company targets damage-associated molecular patterns (DAMPs) such as S100A4 to halt diseases like idiopathic pulmonary fibrosis at their root rather than managing symptoms.
biotech · fibrosisRead →
MG
Executive · Operator · Advisor
Mark Gaffney
Mark Gaffney is the Chief Executive Officer and Board member of Calluna Pharma, an Oslo-based clinical-stage biopharma chasing inflammatory and fibrotic disease by tuning the body's innate immune system. A mechanical engineer turned lawyer turned dealmaker, he spent two decades building and selling biotechs - Oxular went to Regeneron, Vedere Bio to Novartis - before taking the helm of a company born from the merger of Oxitope Pharma and Arxx Therapeutics and freshly backed by a 75 million euro Series A.
biotech · ceoRead →