Tagged: inflammation
13 results
Andrew Herr
Andrew Herr is the founder and CEO of Flykitt (and its parent company Fount), a health and human-performance company that builds systems to eliminate jet lag by targeting circadian disruption and travel-induced inflammation. Before entrepreneurship, he spent over a decade advising the U.S. military on human performance and biotech strategy from the Pentagon's Office of Net Assessment, working with Navy SEALs and fighter pilots. Holding three Georgetown master's degrees and twice named an Army 'Mad Scientist,' Herr has turned the performance secrets of special operators into products trusted by pro sports teams, executives, and everyday travelers.
AltruBio Inc.
AltruBio is a clinical-stage San Francisco biotech developing first-in-class immune checkpoint enhancer antibodies for autoimmune and inflammatory diseases. Its lead program, ALTB-268, targets PSGL-1 to restore T-cell homeostasis, and is advancing through mid-stage trials in ulcerative colitis. The company rebranded from AbGenomics in 2020 under CEO Judy Chou and closed an oversubscribed $225M Series B in 2024.
WellTheory
WellTheory is a virtual autoimmune care platform founded in 2020 by Ellen Rudolph, Claire Rudolph, and Wallace Torres — all personally affected by autoimmune disease. The company pairs licensed registered dietitians and board-certified health coaches with advanced diagnostic testing to help the 50+ million Americans living with autoimmune conditions reduce symptoms and reclaim their lives. Members follow a 12-month personalized program covering nutrition, sleep, stress, and movement. Clinical outcomes show 92% of members reduce symptoms within four weeks, 85% cut ER visits within 16 months, and average annual healthcare savings of $5,181 per patient. Backed by $33.4M in total funding led by General Catalyst, WellTheory serves both individual members ($175/month) and self-insured employers and health plans like Sentara Health Plans.
DeepCure
DeepCure is a Boston-based biotech that uses AI, physics-based simulation, and automated robotic chemistry to design novel small-molecule drugs for hard-to-treat immune and inflammatory diseases. Founded in 2018 by MIT Media Lab researchers, the company pairs deep learning with a proprietary chemical database of up to 10^18 synthesizable compounds and an in-house automated wet lab, aiming to turn AI-generated molecules into real, testable, first-in-class therapies.
Immetas Therapeutics
Immetas Therapeutics is a New Jersey biotech building drugs that target the chronic, low-grade inflammation that drives aging and age-related disease - what scientists call 'inflammaging.' Founded in 2018 by drug-development veteran J. Gene Wang and Harvard aging researcher David Sinclair, the company designs bispecific antibodies and other biologics to reprogram the innate immune system, aiming to treat age-related cancers and inflammatory and autoimmune disease. It raised an $11M Series A from Morningside Ventures in 2020 and partners with GC Biopharma on mRNA therapeutics.
Nilo Therapeutics
Nilo Therapeutics is a New York-based biotechnology company developing a new class of medicines that target the brain-body neural circuits regulating the immune system. Building on discoveries that identified specific vagal neurons controlling systemic inflammation, Nilo aims to restore immune homeostasis centrally rather than broadly suppress the immune system, offering a differentiated approach to treating autoimmune and inflammatory disease. The company launched out of stealth in October 2025 with a $101 million Series A.
Triveni Bio
Triveni Bio is a clinical-stage biotechnology company in Watertown, Massachusetts building first-in-class antibody therapeutics for immunological and inflammatory (I&I) diseases. Born from the 2023 merger of Amagma Therapeutics and Modify Therapeutics, the company pairs a genetics-informed approach with advanced antibody engineering to target root-cause biology rather than just downstream inflammation. Its lead program, TRIV-509, is a half-life-extended monoclonal antibody that inhibits active kallikreins 5 and 7 (KLK5/7) and is in a global Phase 2 proof-of-concept study for moderate-to-severe atopic dermatitis. Backed by roughly $223M across Series A and Series B rounds, Triveni aims to repair the skin barrier and break what it calls efficacy ceilings in dermatology and beyond.
Flykitt
Flykitt is a personalized jet lag prevention system built by Fount, a Los Angeles human-performance company founded by former Pentagon researcher Andrew Herr. It pairs a course of timed supplements, blue-light-blocking glasses, and an AI-powered app that schedules exactly when a traveler should take each pill, wear the glasses, eat, and sleep based on their specific flight. Born from work optimizing Navy SEALs and fighter pilots, Flykitt treats jet lag as a combination of circadian disruption and flight-induced inflammation, and claims the majority of users report minimal to no jet lag.
Mirador Therapeutics
Mirador Therapeutics is a San Diego precision-medicine company building first- and best-in-class therapies for immune-mediated inflammatory and fibrotic diseases. Its Mirador360 engine fuses human genetics, multi-modal patient data, AI and advanced analytics to find novel targets, design combination therapies and identify the patients most likely to respond. Founded in 2024 by the former Prometheus Biosciences leadership team, Mirador launched with more than $400 million and has since raised over $650 million total.
Calluna Pharma
Calluna Pharma is an Oslo-based clinical-stage biotech building first-in-class antibodies that switch off the upstream signals driving inflammation and fibrosis. Formed in 2024 from the merger of Oxitope Pharma and Arxx Therapeutics and backed by a EUR 75 million Series A, the company targets damage-associated molecular patterns (DAMPs) such as S100A4 to halt diseases like idiopathic pulmonary fibrosis at their root rather than managing symptoms.
Olatec Therapeutics
Olatec Therapeutics is a clinical-stage biopharmaceutical company in New York developing a platform of oral NLRP3 inflammasome inhibitors to treat acute and chronic inflammatory diseases. Its lead compound, dapansutrile (OLT1177), is a selective small-molecule NLRP3 inhibitor that has shown clinical benefit and a clean safety profile across gout, heart failure and a broad range of inflammatory and neuroinflammatory conditions, positioning oral inflammasome blockade as a potential alternative to injectable IL-1 biologics.
Damaris Skouras
Damaris Skouras is the founder, chairman, and CEO of Olatec Therapeutics, a New York clinical-stage biopharmaceutical company built around dapansutrile, an oral, specific NLRP3 inflammasome inhibitor she has pushed from the lab bench into Phase 2 trials spanning gout, melanoma, type 2 diabetes, and Parkinson's disease. She started in finance as a Wall Street biotech banker in 1982, founded her own investment advisory firm in 1985, and eventually crossed the table to run the kind of company she used to finance. With a Stanford degree, a Harvard MBA, and the immunologist who discovered interleukin-1 as her co-founder, she has raised over $100 million to bet that a single inflammatory switch can be turned off across a range of diseases.
Mark Gaffney
Mark Gaffney is the Chief Executive Officer and Board member of Calluna Pharma, an Oslo-based clinical-stage biopharma chasing inflammatory and fibrotic disease by tuning the body's innate immune system. A mechanical engineer turned lawyer turned dealmaker, he spent two decades building and selling biotechs - Oxular went to Regeneron, Vedere Bio to Novartis - before taking the helm of a company born from the merger of Oxitope Pharma and Arxx Therapeutics and freshly backed by a 75 million euro Series A.