orbimed
(5)
Neurogastrx, Inc.
Neurogastrx is a Woburn, Massachusetts biopharmaceutical company developing therapies for gastrointestinal disorders rooted in the enteric nervous system. Its lead candidate, NG101, is an oral, peripherally acting dopamine D2 receptor antagonist (a proprietary mesylate salt of metopimazine) in late-stage development for gastroparesis and for the nausea and vomiting that limit GLP-1 weight-loss and diabetes drugs. Backed by roughly $105-125M from OrbiMed, 5AM Ventures and venBio, the company reported Phase 2 data in 2025 showing sizable reductions in GLP-1-induced nausea and vomiting.
PIC Therapeutics
PIC Therapeutics is a Natick, Massachusetts biotechnology company developing small-molecule precision medicines that target cancer at the level of protein translation. Rather than chasing individual oncogenes one at a time, PIC modulates the Pre-Initiation Complex (PIC) and the translation factor eIF4E - a convergence point for many oncogenic signaling pathways - to selectively shut down the production of cancer-driving proteins while sparing healthy cells. Founded on the research of Harvard structural biologist Gerhard Wagner and led by CEO Katherine Bowdish, the company is advancing an allosteric eIF4E modulator toward first-in-human studies in drug-resistant metastatic breast cancer, backed by a $35M Series A led by OrbiMed.
Mendra
Mendra is an AI-native biopharmaceutical company based in San Francisco that acquires, develops, and commercializes therapies for rare and ultra-rare diseases with high unmet need. Founded in 2025 and launched publicly in January 2026 with an $82 million Series A, the company is run by veterans of BioMarin, Palantir, and other rare disease programs. Rather than discovering compounds from scratch, Mendra systematically scans, scores, and acquires shelved or under-resourced rare disease assets from academia, small biotechs, and big pharma, then uses AI to accelerate patient identification, clinical trial enrollment, and global market access.
Robert Jacks
Robert Jacks is President & CEO of Sparrow Pharmaceuticals, a Boston-based clinical-stage biopharmaceutical company developing targeted therapies for disorders driven by intracellular cortisol excess. In September 2025 he closed a $95 million Series B co-led by RA Capital and Forbion to advance clofutriben, an HSD-1 inhibitor, through a Phase 2b trial in type 2 diabetes patients with elevated cortisol. A civil engineer turned biotech operator, Jacks has spent 25 years in the industry, co-founded Symbiomix Therapeutics (sold after Solosec NDA approval), previously led Indalo Therapeutics, and has raised more than $300 million across his companies.
Matthew Loper
Matthew Loper is the co-founder and CEO of Wellth, a Los Angeles digital-health company that pays people small cash rewards for sticking to their care plans. A biological engineer from MIT turned healthcare banker and investor, he built Wellth around behavioral economics rather than technology - the idea that immediate, tangible incentives change what people actually do about their chronic conditions. Under his leadership Wellth has raised more than $73 million, including an oversubscribed $36 million Series C in 2025, and reports steep drops in hospital and emergency-room use among the high-need Medicare and Medicaid populations it serves.