orbimed
(3)
Neurogastrx, Inc.
Neurogastrx is a Woburn, Massachusetts biopharmaceutical company developing therapies for gastrointestinal disorders rooted in the enteric nervous system. Its lead candidate, NG101, is an oral, peripherally acting dopamine D2 receptor antagonist (a proprietary mesylate salt of metopimazine) in late-stage development for gastroparesis and for the nausea and vomiting that limit GLP-1 weight-loss and diabetes drugs. Backed by roughly $105-125M from OrbiMed, 5AM Ventures and venBio, the company reported Phase 2 data in 2025 showing sizable reductions in GLP-1-induced nausea and vomiting.
PIC Therapeutics
PIC Therapeutics is a Natick, Massachusetts biotechnology company developing small-molecule precision medicines that target cancer at the level of protein translation. Rather than chasing individual oncogenes one at a time, PIC modulates the Pre-Initiation Complex (PIC) and the translation factor eIF4E - a convergence point for many oncogenic signaling pathways - to selectively shut down the production of cancer-driving proteins while sparing healthy cells. Founded on the research of Harvard structural biologist Gerhard Wagner and led by CEO Katherine Bowdish, the company is advancing an allosteric eIF4E modulator toward first-in-human studies in drug-resistant metastatic breast cancer, backed by a $35M Series A led by OrbiMed.
Mendra
Mendra is an AI-native biopharmaceutical company based in San Francisco that acquires, develops, and commercializes therapies for rare and ultra-rare diseases with high unmet need. Founded in 2025 and launched publicly in January 2026 with an $82 million Series A, the company is run by veterans of BioMarin, Palantir, and other rare disease programs. Rather than discovering compounds from scratch, Mendra systematically scans, scores, and acquires shelved or under-resourced rare disease assets from academia, small biotechs, and big pharma, then uses AI to accelerate patient identification, clinical trial enrollment, and global market access.