cell-therapy
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Ivan Dimov and the 48-Hour Problem
He began by building hammers and hunting for nails. At Stanford, Ivan Dimov reversed the method - then spent nearly a decade turning a delicate cell-sorting idea into an industrial system.
Caribou Cut a Third of Its Team to Bet the Company on Two Cancer Drugs - Here’s What Focus Costs in Biotech
The CRISPR pioneer traded a sprawling platform story for two off-the-shelf cancer therapies, a smaller herd, and a very specific test: can ready-made CAR-T match custom-built medicine before the cash clock runs out?
Andreas Bader Has Spent 25 Years Turning Biology Into Biotech
From microRNA to engineered T cells to mitochondrial targets, the Austrian biochemist keeps returning to the same hard problem: how to carry a promising mechanism across the unruly distance between a lab result and a real company.
Stan Wang Bet on an Organ Most People Forget. Then Came the $140 Million Deal.
A physician-scientist spent years turning the overlooked thymus into an engineering problem. His path from Akron to Cambridge, the NIH and Harvard ended in a deal - but the longer experiment is only beginning.
The Startup Rebuilding the Organ That Quietly Ages You
Most of biotech chases the diseases you can see. Thymmune went after the organ almost no one thinks about - the thymus - and built a way to grow it from stem cells.
GC Therapeutics Wants to Turn a Four-Day Cell Recipe Into Medicine at Scale
The Harvard spinout says its TFome platform can compress months of stem-cell differentiation into four days. Now it has to prove that programmable cells can survive the far harder journey from an elegant recipe to an approved medicine.
Novartis Cut Away an Empire to Bet on Five Ways of Making Medicine
The Swiss giant spent years shedding businesses until only innovative medicines remained. Now its growth depends on turning five scientific platforms into treatments that health systems will pay for - and patients can actually reach.
Legend Biotech
Legend Biotech turned an experiment from a room the size of a freight elevator into a medicine used to treat more than 10,000 people. Now it must prove that one demanding, personalized therapy can become a platform for the next generation of cancer care.
Arcellx
Arcellx rebuilt a crucial part of CAR-T therapy with a compact synthetic binder. Its lead treatment is now under FDA review - and the company behind it has become part of Gilead's Kite.
Tom Soloway
Tom Soloway is the Chief Executive Officer of T-knife Therapeutics, a transatlantic biotech developing T-cell receptor (TCR-T) therapies aimed at solid tumors. With more than 25 years across strategy, operations, corporate finance and venture capital, he has helped build and finance a string of life sciences companies including Transcept Pharmaceuticals, Ascendis Pharma and Audentes Therapeutics. He took the helm of T-knife in January 2021, positioning the Berlin- and San Francisco-based company to move its 'supercharged' TCR-T candidates into the clinic while staying lean and capital-efficient.
Daniel Getts
Daniel Getts, PhD, is the co-founder and CEO of CREATE Medicines (formerly Myeloid Therapeutics), a Cambridge, Massachusetts biotech building RNA-based in vivo immune programming therapies that reprogram T cells, NK cells and myeloid cells directly inside the body. An immunologist trained at the University of Sydney with an MBA from Western Michigan, he previously founded Cour Pharmaceuticals and served as VP of Research at TCR2 Therapeutics. He has more than 45 peer-reviewed publications, multiple issued patents, and a track record of large pharma partnerships, including Takeda's $420M licensing deal for TIMP-GLIA. In May 2026 CREATE closed a $122 million Series B to advance its in vivo CAR pipeline across autoimmune disease and oncology.
Be Biopharma
Be Biopharma (Be Bio) is a Cambridge, Massachusetts biotechnology company pioneering a new class of therapies called Engineered B Cell Medicines (BCMs). By precisely gene-editing a patient's own B cells - nature's protein factories that can secrete high volumes of protein for decades - Be Bio aims to deliver durable, potentially re-dosable treatments for hemophilia, rare genetic diseases, and other serious conditions. Founded in 2020 out of Seattle Children's Research Institute and Longwood Fund, the company has raised roughly $356 million and, as of early 2025, advanced to a multi-program clinical-stage company led by CEO Joanne Smith-Farrell, Ph.D.
CREATE Medicines
CREATE Medicines is a Cambridge, Massachusetts clinical-stage biotech building in vivo immune programming - therapies that use an mRNA-lipid nanoparticle platform to turn a patient's own T cells, NK cells, and myeloid cells into chimeric antigen receptor (CAR) cells directly inside the body, rather than extracting and re-engineering them in a lab. Formerly Myeloid Therapeutics, the company rebranded in October 2025 as its pipeline expanded beyond myeloid cells and cancer into autoimmune disease and fibrosis. Its repeat-dosable, off-the-shelf approach aims to make CAR therapy cheaper and more scalable than conventional cell therapy, and the company says it has dosed more than 50 patients - among the largest clinical datasets for in vivo CAR to date.
Leucid Bio
Leucid Bio is a clinical-stage London biotech developing next-generation CAR-T cell therapies for refractory solid tumors. Spun out of King's College London in 2014 to commercialize two decades of research by Dr John Maher, the company's proprietary Lateral CAR platform redesigns the CAR receptor so its signalling domains sit laterally alongside the cell membrane - mimicking natural immune receptors to boost potency while reducing toxicity. Its lead candidate, LEU011, is an autologous NKG2D-targeting CAR-T therapy now in the Phase I/IIa AERIAL trial for refractory solid tumors.
Made Scientific
Made Scientific is a Princeton, New Jersey-based contract development and manufacturing organization (CDMO) focused exclusively on cell therapies. Formerly BioCentriq, it was rebranded in March 2025 and is backed by South Korea's GC Corporation. The company runs a 60,000 sq. ft. GMP facility with five ISO 7 / Grade B cleanrooms, offering process and analytical development, GMP manufacturing of autologous and allogeneic products, aseptic fill and finish, QC release testing, regulatory consulting, and workforce training, taking cell therapy programs from preclinical development through commercial supply.
Mirror Biologics, Inc.
Mirror Biologics is a clinical-stage, international biopharmaceutical company developing an 'off-the-shelf' class of immunotherapy built on living, non-genetically-manipulated immune cells. Its patented Mirror Effect platform - protected by more than 200 issued patents - powers a pipeline led by AlloStim for cancer, AlloPrime as a universal anti-viral vaccine for the elderly, and StimVax as a neoantigen vaccine. Headquartered in Tampa, Florida with GMP manufacturing in Jerusalem and clinical operations across Thailand and Malaysia, the company is advancing AlloStim into late-stage trials, including a Phase II metastatic colorectal cancer study run in collaboration with Merck KGaA.
Neurotech Pharmaceuticals, Inc.
Neurotech Pharmaceuticals is a Cumberland, Rhode Island biotechnology company that develops long-acting therapies for chronic retinal diseases using its Encapsulated Cell Technology (ECT) platform - a tiny implant of genetically engineered cells that continuously secretes a therapeutic protein inside the eye. In March 2025 its lead product ENCELTO (revakinagene taroretcel-lwey, formerly NT-501/Renexus) became the first and only FDA-approved treatment for macular telangiectasia type 2 (MacTel), delivering ciliary neurotrophic factor (CNTF) to slow the loss of photoreceptors.
Triumvira Immunologics, Inc.
Triumvira Immunologics is a clinical-stage immuno-oncology company developing engineered T cell therapies built on its proprietary T cell Antigen Coupler (TAC) platform. Unlike CAR-T, the TAC molecule co-opts the natural T cell receptor to recognize and attack cancer cells, aiming for a more physiological immune response with a potentially safer profile. The company advances autologous and allogeneic TAC T cell candidates against solid-tumor antigens such as HER2, Claudin 18.2, GPC3 and GUCY2C.
Filippo Petti
Filippo Petti is the Chief Executive Officer of Leucid Bio, a London-based clinical-stage biotech developing next-generation CAR-T cell therapies for solid tumours built on a proprietary lateral CAR platform spun out of two decades of King's College London research. Appointed CEO in July 2023, Petti pairs a bench-science start at OSI Pharmaceuticals with years on Wall Street as a healthcare investment banker and equity analyst, and a prior run leading Celyad Oncology as CEO and CFO. Under his watch, Leucid moved its lead asset LEU011 into the AERIAL Phase I/IIa trial, reporting early proof-of-concept in relapsed/refractory solid tumours in late 2025.
Joanne Smith-Farrell
Joanne Smith-Farrell is the President and CEO of Be Biopharma, a Cambridge, Massachusetts company building a new class of medicines from engineered B cells - the body's own protein factories. A physicist by training who moved into drug development, she has spent more than 25 years leading teams tackling cancer and rare diseases, most notably building bluebird bio's 400-person oncology cell therapy business behind the CAR-T therapy Abecma. Since taking the helm at Be Bio in early 2021, she has steered the company through more than $350 million in funding as it works to turn B cells into durable, in vivo sources of therapeutic proteins.
Eureka Therapeutics, Inc.
Eureka Therapeutics is a clinical-stage biopharmaceutical company in Emeryville, California, developing next-generation T-cell therapies for cancer, with a focus on hard-to-treat solid tumors. Founded in 2006 by Dr. Cheng Liu, the company pairs its E-ALPHA phage-display antibody engine with its ARTEMIS T-cell receptor platform - an alternative to conventional CAR-T designed to keep engineered T cells potent inside immunosuppressive tumors while sharply reducing the inflammatory cytokine release linked to CAR-T toxicity. Its lead program, ECT204, targets GPC3-positive advanced liver cancer and has received FDA RMAT designation.
Syntax Bio
Syntax Bio is a Chicago synthetic biology company building Cellgorithm, a CRISPR-based platform that programs stem cells to differentiate on command. Instead of coaxing stem cells into specialized cell types through months of manual, growth-factor-heavy protocols, Cellgorithm encodes the sequence of gene activations that mimic human development into a single DNA program, collapsing timelines from months to weeks. Spun out of the University of Illinois Chicago and formerly known as Cellgorithmics, the company has raised more than $25 million and is advancing a pancreatic beta cell therapy for type 1 diabetes while partnering with biopharma to program cells at scale.
T-knife Therapeutics
T-knife Therapeutics is a clinical-stage biotech engineering T-cell receptor (TCR-T) therapies to treat solid tumors. Spun out of Berlin's Max Delbrück Center in 2015, it built a proprietary humanized-TCR mouse platform (HuTCR) that grows a full human immune repertoire in mice, letting the company harvest fully human TCRs naturally selected for affinity and specificity. Now dual-based in San Francisco and Berlin, T-knife is advancing 'supercharged' TCR-T candidates - including a PRAME-targeted, CRISPR-armored therapy (TK-6302) entering the clinic - against cancers that have long resisted cell therapy.
Phillip Maderia
Phillip Maderia is the Chief Executive Officer of PranaX, a Houston-based regenerative-medicine biotech developing stem cell-derived exosome products at the Levit Green campus in the Texas Medical Center. He joined in March 2025 after four years running Lonza's exosome manufacturing site in Lexington, Massachusetts - the facility Lonza bought from Codiak BioSciences in 2021, where Maderia had previously served as VP of Manufacturing Operations. He is a career biomanufacturing operator with roots at Sanofi Genzyme and LFB-USA and roughly three decades of scale-up experience.
Syed T. Husain
Syed T. Husain is the Chairman and CEO of Made Scientific, a Princeton, New Jersey cell therapy contract development and manufacturing organization (CDMO) that he relaunched in 2025 out of the former BioCentriq. Backed by GC Corporation, the company runs a 60,000-square-foot GMP facility built to move autologous and allogeneic cell therapies from clinical batches to commercial supply. A chemical engineer by training who started on the manufacturing floor at Wyeth and Pfizer, Husain spent more than two decades in CDMO leadership at Lonza, Alcami, Emergent BioSolutions, and Resilience before taking the top job. He named the rebranded company MADE for Manufacturing and Development Excellence.
HexemBio
HexemBio is a New York- and Berkeley-based biotech building what it calls the first blood stem cell rejuvenation therapy. Its Synthetic Human Yolk Sac platform recreates the embryonic environment where blood stem cells first arise, temporarily placing a patient's own aged hematopoietic stem cells into that synthetic young niche before returning them by IV infusion - rather than gene-editing or chemically reprogramming the cells. The company launched publicly in April 2026 with a $10.4M seed round led by Draper Associates, holds an FDA Orphan Drug Designation for a bone-marrow-transplant program in blood cancers, and is targeting first-in-human trials in 2027.
K2bio
K2bio is a Houston-based preclinical contract research organization (CRO) built on assets acquired from Bellicum Pharmaceuticals, including a certified mouse vivarium. It pairs full-service GLP and non-GLP in vivo and in vitro research with flexible private and shared lab space near the Texas Medical Center, giving early-stage biotech and pharma teams big-company infrastructure on small-company budgets.
Portal Biotechnologies
Portal Biotechnologies is a Watertown, Massachusetts cell-engineering platform company building tools that push complex cargo - mRNA, siRNA, CRISPR complexes, proteins - into living cells by squeezing them through microscopic holes in a silicon surface, rather than relying on viruses or chemistry. Founded in 2023 by Armon Sharei, the MIT-trained scientist behind SQZ Biotechnologies, Portal sells hardware and consumables to drug discovery and cell therapy labs instead of developing its own drugs. Its instruments are used across more than 100 customer sites, including many of the world's largest pharmaceutical companies, and the company has raised seed and follow-on funding plus a DARPA contract for portable, point-of-care cell manufacturing.
Shennon Biotechnologies
Shennon Biotechnologies is a San Francisco biotech turning immune-cell target discovery from a months-long slog into a same-day job. Its proprietary TCELERATOR platform fuses ultra-high-throughput microfluidics with AI to functionally profile millions of single immune cells in hours, pinpointing the rare T and B cells that recognize cancer antigens. Founded in 2021 by physicist-turned-founder Li Sun, the company is building a pipeline of validated targets for solid tumors and autoimmune disease, backed by a $13M seed round led by DCVC.
Caralynn Nowinski Collens
Caralynn Nowinski Collens is a physician-turned-entrepreneur and the co-founder and CEO of Dimension Bio (formerly Dimension Inx), a Chicago biotechnology company building regenerative therapeutics that give the body a blueprint to heal itself. Its BioNidum platform fuses materials science, 3D-printing, and digital manufacturing to turn cells into implantable, tissue-like therapies. Before biotech, she spent eight years co-founding and running UI LABS, the innovation collaborative that launched MxD, the U.S. national hub for digital manufacturing. She trained as an M.D./MBA at the University of Illinois at Chicago and has been recognized on Crain's Forty Under Forty, Tech 50, and Notable Women in STEM lists.