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Tagged: cid-078
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Health · Ai · Hardware
Circle Pharma, Inc.
Circle Pharma is a South San Francisco biotechnology company building intrinsically cell-permeable, orally available macrocycle therapeutics to hit cancer targets long considered undruggable. Spun out of UCSF and UC Santa Cruz in 2012, it pairs structure-based design, AI/ML, physics-based simulation, and advanced synthetic chemistry in its proprietary MXMO platform. Its lead program, CID-078, is a first-in-class oral cyclin A/B RxL inhibitor now in a Phase 1 trial for advanced solid tumors. The company has raised more than $200 million in total funding, including a $90 million Series D in 2024.
macrocycles · oral macrocycle therapiesRead →
Executive · Operator · Founder
David Earp
David J. Earp is the President and CEO of Circle Pharma, a South San Francisco clinical-stage biopharmaceutical company building orally available macrocycle drugs aimed at cancer targets long deemed undruggable. A biochemist turned patent lawyer turned chief executive, Earp holds a PhD in biochemistry from Cambridge and a JD from Lewis & Clark, and has led Circle since 2013, steering it through a $90M Series D, a $607M collaboration with Boehringer Ingelheim, and the first human dosing of its lead cyclin A/B inhibitor CID-078.
david earp · circle pharmaRead →