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Tagged: alpha-sheet
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Health · Hardware · Enterprise
AltPep
AltPep is a Seattle biotech company spun out of the University of Washington that is building both diagnostic tests and disease-modifying drugs for amyloid diseases such as Alzheimer's and Parkinson's. Its work is anchored on the alpha-sheet, a non-standard protein structure discovered by founder and CEO Valerie Daggett, which forms in the toxic soluble oligomers that appear at the earliest, pre-symptomatic stages of disease. AltPep's SOBA blood test aims to flag those toxic oligomers years before symptoms, while its SOBIN peptide therapeutics are designed to neutralize them.
biotech · alzheimersRead →
Scientist · Founder · Executive
Valerie Daggett
Valerie Daggett is a University of Washington bioengineering professor turned biotech founder who spent three decades running the world's largest collection of protein-folding simulations, stumbled onto a structure nature was not supposed to make, and built a company around it. As founder and CEO of Seattle-based AltPep, she is commercializing the alpha-sheet: a strange protein geometry her lab predicted on a computer before anyone confirmed it in a test tube. Her SOBA-AD blood test, which spots toxic amyloid oligomers years before symptoms, earned FDA Breakthrough Device Designation and put her at the front of the race to catch Alzheimer's early.
biotechnology · protein foldingRead →