Aegis is a San Francisco healthtech startup (YC X25) that automates the insurance denial appeals process for healthcare providers, hospitals, and medical billing groups. Its AI detects denied claims, pulls supporting records from EHRs and clearinghouses, drafts policy-specific appeal letters, and submits and tracks them through payer portals - helping providers recover revenue that would otherwise go unclaimed because appeals are too slow and costly to file by hand.
Chronica is a San Diego digital-health company that runs remote patient monitoring (RPM) and chronic care management (CCM) as a managed service. Built on parent company Hifinite Health's hiCare platform, Chronica pairs a cloud-based, HIPAA-compliant software stack with the parts most clinics don't want to build themselves: the connected devices, the in-house clinicians, the call center, and the billing paperwork tied to CMS reimbursement codes. Providers - from outpatient practices to hospitals, ACOs, and home-health agencies - get to extend care beyond the exam room without upfront costs, long contracts, or patient minimums.
Legion Health is an AI-native psychiatry practice that delivers world-class mental health care covered by insurance. The company automates the administrative work behind clinical care - and became the first to receive regulatory authorization for AI to prescribe psychiatric medications, starting in Utah.
Virta Health is a digital health company on a mission to reverse type 2 diabetes and obesity in 100 million people. Founded in 2014 by Sami Inkinen, Dr. Stephen Phinney, and Dr. Jeff Volek, Virta pairs a nutrition-first, low-carbohydrate clinical protocol with a Continuous Remote Care platform - a mobile app, dedicated physicians and health coaches, and AI-driven personalization - to lower blood sugar, cut medications, and produce durable weight loss without relying on costly drugs or surgery. Sold to employers and health plans on a value-based, outcomes-guaranteed model, Virta has treated over 100,000 members and surpassed $160M in annualized revenue.
Forta is a San Francisco-based virtual ABA therapy company that pairs board-certified behavior analysts with families across 47 states, using AI-assisted clinical algorithms to deliver autism care without the years-long waitlists that define the industry.
House Rx is a San Francisco-based healthcare technology company that partners with specialty clinics to enable medically integrated dispensing (MID) - a model where physicians, pharmacists, nurses, and care coordinators work together as one unified team. Founded in 2021 by Flatiron Health veterans Ogi Kavazovic and Tesh Khullar, the company builds AI-enabled pharmacy management software that keeps specialty medications dispensed at the point of care, cutting average time-to-therapy from 15.5 days to 3.5 days and achieving 95% medication adherence. With $100M raised across Seed, Series A, and Series B rounds, House Rx serves 80 clinic sites, 1,000+ providers, and nearly 61,000 patients, processing approximately $1.5 billion in specialty prescriptions annually.
Adnan Iqbal is the Co-Founder and CEO of Luma Health, a San Mateo-based healthcare technology company that has built an AI-native Patient Success Platform used by 750+ healthcare organizations, 100 million patients, and 500,000+ providers. A second-generation Pakistani-American and serial entrepreneur, Iqbal studied environmental biology at UC Berkeley, earned an MPhil in BioScience from Cambridge University, and an MS/MBA from Stanford GSB. Before Luma, he spent five years in management at Genentech and co-founded AutoTB, a tuberculosis diagnostic startup that won both Cambridge and UC Berkeley entrepreneurship competitions. Luma Health has raised $160 million in funding and enabled $3.2 billion in healthcare revenue.
Ian Christopher is the Co-Founder and Chief Engineer of Qventus, the AI-powered hospital operations platform backed by KKR and Bessemer Venture Partners. A Stanford-trained computational engineer, he co-built Qventus from a 2012 YC startup into a $400M+ company that automates how hospitals manage patient flow, surgical scheduling, and care coordination - reducing staff burnout and cutting length of stay for major health systems across the US.
Keith Carter is a healthcare technology operator with deep roots in medical imaging and surgical data infrastructure. Currently VP of Implementations & Integrations at Caresyntax - the AI-powered surgical intelligence platform used in 3,500+ operating rooms worldwide - he also serves as CEO of Cloud9PACS.com, a digital PACS system he built from the ground up. Carter's career traces the arc of healthcare IT: from PACS architect at Medlink to running his own imaging solutions company, to joining one of the most-funded surgical AI ventures in the industry. He is based in Hattiesburg, Mississippi.
Khanh Nguyen is the CEO of Cozeva, the operating system for value-based care that manages over 25 million lives across 97,000+ providers. A PharmD from UCSF with 15+ years pioneering payer-provider collaboration, she led Cozeva to a reported $480M merger with Vatica Health in 2025, combining the #1-rated Best in KLAS risk adjustment platform with Cozeva's #1 quality platform - creating the most comprehensive value-based care enablement company in the U.S.
Tassos Gianakakos is a Greek-American biotech entrepreneur and the co-founder, CEO, and Chair of Kardigan, a cardiovascular drug discovery company he built from the ashes of MyoKardia — the precision-medicine heart company he led to a $13.1 billion acquisition by Bristol Myers Squibb in 2020. At Kardigan, he is applying the same playbook: marrying real-world clinical data, AI tools, and deep cardiovascular biology to deliver personalized medicines for heart disease — a field he believes is where oncology was 20 years ago. With $554 million raised and three late-stage clinical programs underway, Gianakakos is on a mission to make cardiovascular disease preventable and curable.