Varcon built a national business around an unglamorous truth: towers age, bolts crack, and paperwork can be as dangerous as wind. Its advantage is closing the gap between the engineer who finds the problem and the crew that fixes it.
A near-miss with a dog named Daisy turned a 30-year security engineer into an RV-sensor entrepreneur. The result is a phone dashboard that watches the things you can't - and pings you before they go wrong.
Piyush Gupta left Abbott, watched his wife struggle with gestational diabetes, and decided the fix wasn't a better sensor - it was a cheaper one. A decade later, Ambrosia Systems sells glucose tech in 100-plus countries and just put the whole thing on your finger.
A failed universal-remote company rebuilt itself around one uncomfortable truth: the hardest part of caring for aging parents is the 300-mile drive to fix their TV. JubileeTV turns that TV into the caregiving hub instead.
A camera that wakes up, takes the right frame and goes back to sleep sounds modest. On a construction site, that small trick became a hardware-and-software business built around fewer site visits, cleaner project records and equipment that can stay outside for months.
A retired fighter pilot from a Nebraska ranching family set out to build a water-tank sensor. His customers told him what they actually wanted: eyes on the land, no Wi-Fi required.
A garage-built doorbell became a reported $1 billion Amazon acquisition by turning the front porch into software. The playbook is worth stealing; the privacy bill is not optional.
Jean Anne Booth sold two chip companies to Texas Instruments and Apple, then un-retired to solve one stubborn problem: her 80-year-old mother would not wear anything that looked like a call-for-help button.
Hospitals, utilities and microgrids were full of useful machines that could not share data. Blue Pillar found a practical business in connecting the awkward old stuff - often in days, sometimes for a few thousand dollars - and became part of Generac in 2022.
Most people have never heard of ConnectWise. But if a small business somewhere fixed your laptop last week, the outsourced IT shop that did it was probably running on ConnectWise software.
Pelago is a virtual clinic for substance use management, delivering physician-led, evidence-based care for tobacco, alcohol, opioid and other substance use. Founded in 2017 as Quit Genius by three Imperial College London physicians, the company combines cognitive behavioral therapy, medication-assisted treatment and at-home monitoring tools into a program sold to employers, health plans and pharmacy benefit managers. Pelago says it has supported more than 750,000 members and validates its approach with 13 peer-reviewed studies.
Wesper is a New York-based sleep-health company that has built a wireless, wearable patch and cloud platform for clinical-grade, at-home sleep apnea testing. Founded in 2017 (originally as Tatch) by Dr. Amir Reuveny and Adi Mordechai, Wesper combines flexible printed electronics, machine learning, and a provider portal to replace the wires and single-night snapshots of traditional sleep labs with comfortable, repeatable, longitudinal testing. The FDA-cleared Wesper Lab lets patients test at home while giving physicians high-resolution data that correlates closely with in-lab polysomnography.
Delfina is a San Francisco-based maternal health company that pairs an AI-powered clinical platform with a consumer pregnancy app to make prenatal care proactive rather than reactive. Its predictive models flag rising risk - preterm birth, hypertensive disorders, gestational diabetes - while patients track vitals from home and connect around the clock with bilingual virtual doulas, dietitians, and mental health support. Founded in 2021 by physician-scientist Dr. Senan Ebrahim and his co-founders, Delfina sells to health plans, providers, and employers, and has raised roughly $22M to date, including a $17M Series A in January 2025.
SuperOps is an AI-native IT management platform that folds professional services automation (PSA), remote monitoring and management (RMM), unified endpoint management, service desk, patching, and documentation into one system. Founded in 2020 by Arvind Parthiban and Jayakumar Karumbasalam, it targets managed service providers (MSPs) and in-house IT teams, pitching a single pane of glass that replaces the 10-15 tools an MSP typically stitches together. Backed by $54.4M in venture funding, it added an agentic AI assistant, 'Monica,' and expanded from MSP tooling into internal IT teams with a cross-OS UEM product.
Xyte is a cloud platform that lets hardware manufacturers, system integrators, and enterprises connect, monitor, service, and commercialize their connected devices from a single place. Its Xyte Device Cloud (also branded as a Connected Device Management Platform) turns physical products into software-driven, subscription-ready services - handling everything from remote monitoring and firmware updates to billing and AI-assisted support. Founded in 2019 by AV-industry veteran Omer Brookstein and software builder Boris Dinkevich, Xyte works with manufacturers across pro AV, unified communications, smart buildings, medical, and robotics, including names like Crestron, Legrand, Poly, QSC, Biamp, and Panasonic.
ATDev (Assistive Technology Development, Inc.) is a UC Berkeley spinout building an ecosystem of robotic devices that help people stay independent. Its flagship product, Reflex, is a smart, under-5-pound robotic knee brace that delivers personalized, telehealth-enabled physical therapy at home and streams progress data back to clinicians. Founded by engineer Todd Roberts and disability-rights advocate Owen Kent, the company designs 'for users, by users' and is scaling after a $3M seed round while also serving as a subcontractor on a $41M ARPA-H robotic mobility program.
Ceresti Health is a Carlsbad, California digital-health company that turns family caregivers into the front line of dementia care. Through a cell-enabled tablet, weekly one-on-one coaching from a personal care navigator, and claims-driven predictive analytics, Ceresti helps spouses and adult children spot the small changes - a urinary tract infection, a missed medication - that otherwise snowball into costly hospitalizations. The company sells to Medicare Advantage plans, ACOs, and providers operating under the CMS GUIDE payment model, and backs its program with a documented cost-savings guarantee: more than 50% fewer avoidable hospitalizations and roughly $6,800 in medical savings per enrolled patient per year.
Earth Force Technologies is a San Francisco climate-tech company modernizing wildfire prevention. It builds precision-forestry sensors, in-cabin tablets, and a web portal that give crews real-time, tree-level guidance during fuel-treatment work and let administrators oversee far more acres from a desk. By combining teleoperated machinery, jobsite connectivity, and automated reporting, the company aims to make landscape-scale forest treatments faster, safer, and cheaper - so states, federal agencies, and conservation districts can reduce catastrophic fire risk at the pace the crisis demands.
Adhera Health builds an empathic AI 'precision digital companion' for families managing pediatric chronic conditions - growth hormone therapy, type 1 diabetes, childhood obesity, autoimmune and oncology cases. The platform pairs behavioral science with personalization technology to support caregivers, improve treatment adherence, and surface what happens between clinical visits.
Adona Medical is a clinical-stage medical device company in Los Gatos, California developing the Delphi System, a chronically adjustable interatrial shunt with integrated bi-atrial pressure monitoring designed to personalize heart failure therapy over time. A Shifamed portfolio company founded in 2019 by Brian Fahey, Amr Salahieh, and Lewis Schwartz, Adona uses shape memory nitinol and an external induction catheter to resize the shunt after implantation without further invasive procedures.
iSono Health builds ATUSA, an FDA-cleared wearable 3D ultrasound platform that scans both breasts in about two minutes without a specialized sonographer. The South San Francisco startup uses AI to make breast imaging portable, reproducible, and accessible at the point of care.
G-Tech Medical builds the GutTracker, a thin wireless wearable patch its team calls an 'EKG for the Gut.' Worn on the abdomen for up to six days at home, the patch reads the faint electrical signals that drive the stomach, small intestine, and colon, then streams them over Bluetooth to the cloud, where algorithms turn the noise into patient-specific motility data. The Mountain View company aims to replace short, single-organ, in-clinic tests with continuous, whole-gut measurement so physicians can finally see how a digestive system actually behaves day to day.
Virta Health is a digital health company on a mission to reverse type 2 diabetes and obesity in 100 million people. Founded in 2014 by Sami Inkinen, Dr. Stephen Phinney, and Dr. Jeff Volek, Virta pairs a nutrition-first, low-carbohydrate clinical protocol with a Continuous Remote Care platform - a mobile app, dedicated physicians and health coaches, and AI-driven personalization - to lower blood sugar, cut medications, and produce durable weight loss without relying on costly drugs or surgery. Sold to employers and health plans on a value-based, outcomes-guaranteed model, Virta has treated over 100,000 members and surpassed $160M in annualized revenue.
EyeQue Corporation is a Newark, California digital-health company that turns an ordinary smartphone into a personal vision-testing lab. Built on optical technology licensed from MIT, its small clip-on devices and apps let people measure their own refractive error, pupillary distance and reading numbers at home for a fraction of the cost of a clinic visit, then use those results to order glasses online. Founded in 2015 by physicist John Serri and Zenni Optical's Tibor Laczay, EyeQue has won multiple CES Innovation Awards and raised more than $57 million to make eye care accessible to people who can't easily reach an eye doctor.
MarketSpark is a Bannockburn, Illinois company that replaces aging copper phone lines (POTS) for large enterprises with a managed, carrier-agnostic wireless service. As traditional carriers decommission their analog networks, MarketSpark keeps fire alarms, elevator phones, fax lines, alarm panels and voice lines working using cloud-managed 4G LTE/5G hardware, real-time monitoring and remote diagnostics - serving hundreds of America's largest enterprises across tens of thousands of locations.
Renewance, Inc. is an Elmhurst, Illinois company that manages the full life cycle of industrial batteries - from installation and remote monitoring to decommissioning, repurposing, and recycling. Founded in 2015 by three former GE Energy Storage leaders, it pairs hands-on field services with the RenewanceConnect software platform so energy-storage and EV operators can track assets, stay compliant, and retire batteries safely instead of letting them become environmental liabilities.
Curavit Clinical Research is a Boston-based, all-virtual Contract Research Organization (CRO) that designs and runs decentralized clinical trials. Through its Virtual Clinical Site and STRATUS platform, Curavit recruits, enrolls, and monitors diverse patient populations remotely - eliminating physical site infrastructure and travel while improving data quality. The company specializes in trials for digital therapeutics (DTx) and partners with sponsors and existing CROs to fix the execution layer of clinical research, accelerating timelines and lowering costs.
Impress is a Barcelona-based orthodontic company building Europe's largest chain of clear-aligner clinics. Founded in 2019, it pairs in-clinic, orthodontist-led treatment with AI-driven planning and remote digital monitoring to make discreet teeth straightening faster, more convenient, and more affordable. After acquiring DrSmile in 2024, Impress operates over 110 clinics across roughly ten countries in Europe and the United States.
Omada Health is a publicly traded (Nasdaq: OMDA) virtual chronic care company that uses behavioral science, connected devices, AI tools, and human care teams to help people manage prediabetes, diabetes, hypertension, high cholesterol, musculoskeletal conditions, and weight - including support for members on GLP-1 medications. Founded in 2011 in San Francisco, it sells to employers, health plans, and pharmacy benefit managers, serving roughly 2,000-plus customers and more than 886,000 members.
OrthoFX is a Fremont, California clear-aligner company building the next generation of orthodontic care - shorter-wear NiTime aligners made of a proprietary HyperElastic polymer, paired with FXOnTrack, an AI platform that lets doctors monitor patients remotely. Founded by Invisalign veterans, it is a hybrid B2B/D2C model designed to make straight teeth predictable, affordable, and a lot less tedious.