metabolic-health
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Biolinq puts the answer in a little blue light
Fourteen years after starting with sweat sensors, Biolinq has an over-the-counter glucose wearable. Its most revealing feature is the one that lets you leave your phone alone.
NNB Nutrition makes the ingredients behave
A supplement can have a handsome label and a troublesome molecule. NNB Nutrition builds its business in the space between what an ingredient promises and what a manufacturer can actually make.
Veracity found its next business in a bottle
Veracity began by asking what hormones could reveal about skin. A metabolic supplement changed the answer - and the direction of the company.
Nourish Wants Your Insurance to Pay for Eating Better
The company made dietitian visits easier to book and easier to afford. Now it is betting that nutrition, medication and a little help between appointments belong in the same clinic.
Syntis Bio wants to put a detour in your daily pill
A mussel-inspired intestinal coating is the unlikely foundation of Syntis Bio’s obesity program. Its daily tablet aims to borrow a metabolic trick from gastric bypass, with early human results and a much longer test still ahead.
The Meal Was Still on the Plate
PurpleTeal built a nutrition business around one small correction: advice is more useful before dinner than after it. Its route from telecom messages to meal photos and hospital follow-up shows what happens when a health app chooses the moment of decision.
The Doctor Wasn't Missing. The Team Was.
Allara's wager is disarmingly simple: the problem with hormonal care is not always a missing specialist. It is that the specialists rarely behave like a team.
The Startup That Learned the Doctor Was the Door
Salvo Health began by asking patients to walk around the healthcare system. Then it discovered the more useful trick: walk through the front door, beside their own doctor.
Noom Took Nine Years to Find Its Formula. Then Ozempic Rewrote the Recipe.
The company that taught dieters to examine their habits is now prescribing medicine, scanning faces and mailing blood-test kits. Its second reinvention asks whether behavior change can remain the product when the drug works faster.
Phenotap’s $3 Million Pivot: The Ketone Wearable Became an Enzyme Business
The New York startup began with a wearable that promised hourly ketone trends. Its sharper bet is now one layer deeper: sell device makers the missing biochemical engine.
The company that turned a $6,000 diabetes gadget into a $249 ring
Piyush Gupta left Abbott, watched his wife struggle with gestational diabetes, and decided the fix wasn't a better sensor - it was a cheaper one. A decade later, Ambrosia Systems sells glucose tech in 100-plus countries and just put the whole thing on your finger.
Vytal Health Bet Patients Would Pay to Be Heard - Then Built a $300-a-Month Alternative to the 10-Minute Visit
The Milwaukee telehealth practice asks patients to pay outside insurance for time, continuity and deeper testing. Its early obstacle was convincing people that a video visit could still feel human; its sharper 2026 answer is a two-tier membership with unusually clear boundaries.
The Medical-Food Company That Learned to Own the Last Mile
Alfasigma USA sits in the narrow lane between prescription medicine and everyday nutrition. Its advantage is not one miracle ingredient, but control of the route from formulation and factory floor to clinician and customer.
Prana
Prana is a San Francisco startup building a 24/7 AI doctor that watches your health data between checkups. It pulls your medical records and wearable data into one clinical timeline, watches for early warning signs the company calls 'clinical drift' - rising blood pressure or glucose weeks before a crisis - and lets you chat with its AI for free or see a real physician for a flat $39 visit. Founded by Meer Patel, Vishvam Rawal, and Sanjit Menon, Prana launched out of Y Combinator's Winter 2026 batch.
Ultrahuman
Ultrahuman is a Bengaluru-founded health-technology company building a subscription-free wearable and diagnostics ecosystem centered on its Ring AIR and Ring PRO smart rings. Beyond the ring, the company sells a continuous glucose monitor (M1), a home environmental sensor (Ultrahuman Home) and a blood-biomarker service (Blood Vision), stitching them into a single app that turns sleep, movement, metabolic and recovery data into personalized nudges. Founded in 2019 by Mohit Kumar and Vatsal Singhal, it is now the second-largest smart-ring maker by units sold and is expanding US manufacturing to challenge market leader Oura.
Jahangir Mohammed
Jahangir Mohammed is a serial entrepreneur and inventor who built Jasper Technologies into the world's largest IoT platform - sold to Cisco for $1.4 billion in 2016 - then turned his attention to metabolic disease. As Founder and CEO of Twin Health, he is using AI-powered whole-body digital twin technology to reverse chronic conditions like Type 2 diabetes, with clinical results published in the New England Journal of Medicine Catalyst showing 71% of participants achieving A1C below 6.5% while eliminating most medications. Twin Health has raised $335 million total and reached a $950 million valuation in 2025.
Helicore Biopharma
Helicore Biopharma is a South San Francisco clinical-stage biopharmaceutical company building first-in-class GIP (glucose-dependent insulinotropic polypeptide) antagonists for obesity and cardiometabolic disease. Its lead candidate, HCR-188, is a humanized monoclonal antibody that binds circulating GIP ligand rather than the GIP receptor, a mechanism designed to improve the quality of weight loss - favoring fat loss over lean mass when paired with GLP-1 - and to restore leptin sensitivity. Incubated by Versant Ventures, the company emerged from stealth in January 2025 with a $65 million Series A and is advancing a pipeline of long-acting antibody-peptide conjugates aimed at quarterly dosing.
Parsley Health
Parsley Health is a functional-medicine telehealth provider founded in 2016 by physician Dr. Robin Berzin. It pairs in-depth diagnostics and biomarker testing with longitudinal, team-based care - doctors plus health coaches - to find and treat the root causes of chronic conditions like gut, autoimmune, hormonal, metabolic and mental-health issues, rather than just managing symptoms. Originally a cash-pay membership model with clinics in New York and Los Angeles, Parsley has shifted to a virtual-first national service and in 2026 became the first functional-medicine provider to accept insurance in-network nationwide, putting its care within reach of roughly 150 million insured Americans.
Virta Health
Virta Health is a digital health company on a mission to reverse type 2 diabetes and obesity in 100 million people. Founded in 2014 by Sami Inkinen, Dr. Stephen Phinney, and Dr. Jeff Volek, Virta pairs a nutrition-first, low-carbohydrate clinical protocol with a Continuous Remote Care platform - a mobile app, dedicated physicians and health coaches, and AI-driven personalization - to lower blood sugar, cut medications, and produce durable weight loss without relying on costly drugs or surgery. Sold to employers and health plans on a value-based, outcomes-guaranteed model, Virta has treated over 100,000 members and surpassed $160M in annualized revenue.
Bloom Science, Inc.
Bloom Science is a San Diego clinical-stage biotech translating the biology of the ketogenic diet into oral live biotherapeutics that act through the gut-immune-brain axis. Built on microbiome research licensed from UCLA and powered by its IrisRx discovery platform, the company is developing BL-001, a once-daily bacterial therapy being studied in obesity and in drug-resistant seizures from Dravet syndrome, with a pipeline reaching toward ALS and neurodegenerative disease.
resbiotic
resbiotic is a physician-founded microbiome health company building clinically tested probiotics, prebiotics, postbiotics, and bioactive botanicals around its Gut-X Axis platform - the idea that the gut talks to the rest of the body. Its flagship resB Lung Support is positioned as the first clinically tested probiotic targeting the gut-lung axis for respiratory health. Founded in 2020 by physician-scientist Dr. C. Vivek Lal out of microbiome research at the University of Alabama at Birmingham, the company sells direct-to-consumer and through retail including Walmart and GNC, and has raised roughly $20.6M to date.
Peter DiLaura
Peter DiLaura is the CEO and Board Director of Helicore Biopharma, a San Mateo biotech building long-acting antibody-peptide conjugates that go after obesity by neutralizing the GIP hormone in the bloodstream rather than blocking its receptor. With nearly three decades of company-building behind him - CEO roles at Initial Therapeutics and Second Genome, business and strategy chief at Sonoma Biotherapeutics, and time as an Entrepreneur-in-Residence at Third Rock Ventures - he is the operator brought in to turn a $65M Series A and a clinic-ready antibody into medicines that aim for quarterly dosing and better-quality weight loss.
Sami Inkinen
Sami Inkinen is a Finnish-born, Stanford-trained entrepreneur and the co-founder and CEO of Virta Health, a company on a mission to reverse metabolic disease in one billion people through nutrition, technology, and AI. He earlier co-founded the real estate marketplace Trulia, taking it public in 2012 before its merger with Zillow. A self-described 'incurable data geek' and world-class endurance athlete, he is a triathlon age-group world champion and, in 2014, rowed 2,750 miles unsupported across the Pacific from California to Hawaii with his wife in a record-setting 45 days to raise awareness about sugar and metabolic disease.
Twin Health
Twin Health builds a Whole Body Digital Twin - a real-time AI model of each member's metabolism that learns from wearable sensors, labs, and daily behavior to reverse type 2 diabetes, obesity, and other chronic metabolic conditions without long-term reliance on medications.
Signos
Signos is a San Francisco Bay Area digital health company pairing a continuous glucose monitor with an AI-driven app to help non-diabetic adults lose weight and improve metabolic health through real-time, personalized feedback on food, sleep, stress and exercise.
Sharam Fouladgar-Mercer
Sharam Fouladgar-Mercer is the Co-Founder and CEO of Signos, the company behind the first FDA-cleared over-the-counter glucose monitoring system for weight management. A Princeton computer science graduate and Harvard MBA, he played NCAA Division I ice hockey before building a career spanning VC at Sierra and Shasta Ventures, co-founding PR tech company AirPR (later Onclusive), and ultimately creating Signos in 2018 after his own lifelong struggle with weight and the death of his diabetic grandmother inspired him to ask: why wait until someone is sick to give them metabolic data?
Sam Corcos
Sam Corcos is a four-time founder and the co-founder and former CEO of Levels Health, a $300M metabolic health company that pairs continuous glucose monitors with a software layer to help people understand how food affects their blood sugar. He co-founded CarDash (Y Combinator S17, acquired 2020), Sightline Maps, and LearnPhoenix before building Levels into a category-defining health company with $67M raised from a16z and a community of 1,400+ member-investors. In 2025, he joined the Department of Government Efficiency (DOGE) and was appointed U.S. Treasury Chief Information Officer. He is also known for extreme minimalism (one pair of pants, one backpack), tracking time in 15-minute increments, and hosting 100+ intellectual salon dinners in New York and San Francisco.