The company betting that the most expensive corner of American medicine - cancer, cardiology, and back surgery - can be run better when the people paying for care and the doctors delivering it are finally pulling in the same direction.
The company that runs the plumbing behind American medical bills is betting AI can drain billions in administrative waste - and half the country's patients are already in its pipes.
EXL spent a quarter-century learning the unglamorous machinery of claims, payments and customer service. Now it is using that operational memory to turn enterprise AI from a promising demo into work that survives contact with the real world.
Aktana spent years turning pharma’s scattered customer data into a daily recommendation engine. Now, under PharmaForceIQ, its field intelligence is being stitched to digital orchestration in a bid to close one of life sciences’ most expensive gaps.
HealthMetrics is a Malaysia-based digital third-party administrator (TPA) that runs a cloud platform for managing corporate employee health benefits across Southeast Asia. It connects employers, insurers and a network of 15,000+ healthcare providers to automate claims, cut administrative work and give companies real-time visibility and control over rising healthcare costs. Founded in 2015 by Alvin Yuan and Advent Phang, it now serves 3,000+ corporate clients and 100+ insurers in Malaysia, Singapore and Indonesia.
Flume Health is a New York-based healthcare technology company building operational infrastructure that connects the fragmented data ecosystem behind health plans. Founded in 2017 by Cedric Kovacs-Johnson and Vineeth Bhuvanagiri, Flume gives payers, third-party administrators, and vendors a way to move, translate, and make sense of healthcare data. It started as a plan administrator, pivoted to the Relay integration platform, and has since evolved into an AI-native data platform - mapping enterprise data estates into a living knowledge graph and running domain-specific AI agents so non-technical teams can query and act on healthcare data in plain language.
RV Healthcare Solutions (RVH Solutions), which operates the Teamwrks technology suite, is a New York-based healthcare technology company that uses artificial intelligence and machine learning to help hospitals and health systems improve financial and quality performance without reducing staff. Grown out of Workforce Prescriptions and backed by Rizk Ventures and Vizient, Teamwrks turns operational data into department-level targets, AI-driven root-cause insights and actionable workflows - typically deployed in days rather than months.
Scripta Insights is a Needham, Massachusetts healthcare technology company that helps self-insured employers, health plans and their members cut pharmacy benefit costs without switching PBMs. Its Rx Navigation platform, powered by the proprietary Med Mapper AI engine, analyzes prescription claims and clinical data to surface lower-cost, therapeutically equivalent medication options - getting patients 'The Right Meds at The Best Price.' Founded in 2019 by serial entrepreneur Eric Levin and physician Dr. Paul Bradley, the company serves more than 80 employer and health-plan clients and raised $42M total after a $17M Series B in December 2024.
Vytalize Health is a value-based care enabler and Accountable Care Organization (ACO) that helps independent primary care physicians care for Medicare patients while lowering the total cost of care. Founded in 2014 and headquartered in Hoboken, New Jersey, it pairs a physician-built clinical data platform (Vytal Insights) with a wraparound clinical team and virtual clinic (Vytal Care) so small practices can succeed in Medicare's advanced value-based programs like ACO REACH and MSSP. The company serves hundreds of thousands of Medicare beneficiaries across dozens of states and was named the No. 1 fastest-growing private company in America by Inc. in 2024.
CLOUDSUFI is a Silicon Valley data-driven digital transformation company that helps enterprises turn raw, siloed information into decisions - a mission it captures in the phrase 'we make enterprise data dance.' Founded in 2019 and headquartered in San Jose, California, the firm pairs data engineering, advanced analytics, and generative AI with a Google Cloud Premier partnership to modernize data platforms, automate supply chains, and unlock data monetization for customers across manufacturing, retail, financial services, energy, and digital-native industries.
Cozeva is a cloud-based, real-time data platform built by Applied Research Works that helps health plans, physician organizations, and their partners move from fee-for-service to value-based care. It unifies quality measurement (HEDIS, Medicare Stars, P4P), risk adjustment (HCC coding and recapture), and population health analytics in a single, EHR-interoperable system that lets clinicians act on care gaps at the point of care. Founded in 2012 and based in San Ramon, California, Cozeva serves 25M+ lives and 97,000+ providers, holds NCQA and HITRUST certifications, and earned Best in KLAS recognition in 2025 and 2026. In October 2025 it merged with Vatica Health to combine top-ranked quality and risk-adjustment platforms.
Arbital Health is a San Francisco-based healthcare technology company that combines an AI-powered software platform with a bench of credentialed actuaries to help payers and providers design, monitor, reconcile, and adjudicate value-based and risk-based contracts. Founded in November 2023 by Travis May and Brian Overstreet, it positions itself as a neutral third-party infrastructure layer for the shift to value-based care, centralizing fragmented claims, benchmark, and contract data and automating actuarial calculations such as IBNR and MLR.
Delfina is a San Francisco-based maternal health company that pairs an AI-powered clinical platform with a consumer pregnancy app to make prenatal care proactive rather than reactive. Its predictive models flag rising risk - preterm birth, hypertensive disorders, gestational diabetes - while patients track vitals from home and connect around the clock with bilingual virtual doulas, dietitians, and mental health support. Founded in 2021 by physician-scientist Dr. Senan Ebrahim and his co-founders, Delfina sells to health plans, providers, and employers, and has raised roughly $22M to date, including a $17M Series A in January 2025.
Atrix AI is a New York-based startup building a generative-AI platform for life sciences teams - medical affairs, commercial, clinical, and regulatory - to turn messy, siloed data and research into compliant, auditable insights. Its no-code workflow engine connects sources like MSL conversations, advisory-board outputs, and KOL engagement into dashboards, reports, and impact measurements without requiring engineers or data scientists. Founded by ex-Uber and ex-Meta engineer Vera Kutsenko, the company raised a seed round backed by Pear VC, Bling Capital, and others.
Exactrx is a Nashville- and New York-based healthcare AI company that automates revenue cycle management for ambulatory surgery centers and outpatient providers. Its platform reads the operative note, codes the case, validates each charge against more than 80,000 payer rules with a tri-engine system, and generates a submission-ready claim in under 30 seconds - leaving humans to review and submit. Founded in 2024 by Athena Doshi and a clinician-and-engineer team, the company positions itself as access-to-care infrastructure rather than billing software, aiming to recover the revenue that denials and documentation gaps quietly drain from surgical facilities.
Radial (Radial Analytics, Inc.) is a Concord, Massachusetts healthcare technology company that builds AI-driven decision support software for value-based care. Its flagship platform, Smart Placement, uses machine learning and natural language processing to help hospitals, health plans, and accountable care organizations decide - in real time - which patients can safely recover at home instead of in a skilled nursing facility after a hospital stay. Founded in 2014 by former Locately co-founders Thaddeus Fulford-Jones and Eric Weiss alongside physician Anant Vasudevan, Radial applies 'nudge theory' at clinical crossroads moments to lower costs and improve outcomes without overriding clinician judgment.
Translucent AI is an AI-native financial operating system built specifically for healthcare providers. Its agentic platform unifies clinical, operational, and financial data, then deploys AI agents that continuously monitor P&L, labor, service line profitability, revenue cycle, and payer contracts - answering complex finance questions in plain language and surfacing root causes in real time. Founded in 2024 in New York by former health-system CIO Jack O'Hara, the company aims to give every hospital its own 24/7 financial analyst, replacing the spreadsheet-driven, consultant-dependent FP&A work that has long defined healthcare finance.
Accorded is a San Francisco-based healthcare actuarial intelligence company that pairs actuarial expertise with software to simplify and scale value-based contracting. Its platform helps payers, providers, and digital-health companies forecast, contract around, and validate the financial value of care across the value-based contracting lifecycle. Founded in 2019 (originally as Cerebrae) by health actuary Frank Cheung and engineer Thomas Bedington, the company's flagship product, Acumen, turns raw claims, eligibility, and engagement data into standardized, actuarially rigorous, ready-to-use data assets so analytics teams can spend less time wrangling data and more time on strategy.
Collective Health is a San Francisco-based health benefits technology company that operates an integrated platform for self-funded employers. It brings medical, dental, vision, pharmacy, and digital health partners together in one system, pairing claims administration with a member app, care navigation, and analytics so employers can control costs while making coverage easier for employees to understand, navigate, and pay for.
Garner Health is a New York-based healthcare technology company that analyzes billions of medical claims to identify the highest-performing doctors, then pairs that data with employer-funded financial incentives so employees can see top providers at a fraction of the out-of-pocket cost. Founded in 2019 by Nick Reber, the company combines a member-facing care navigation app and concierge with a provider analytics engine (Garner DataPro / Garner Research Agent) used by employers and health plans to cut healthcare spend while improving outcomes.
QURA, Inc. is a preclinical medical-technology company in Massachusetts building a tiny implanted sensor that continuously measures blood pressure and wirelessly transmits medical-grade waveform data to patients and physicians in real time. Its QSmart platform - a vitamin-sized QSense implant paired with software and analytics - aims to replace the occasional cuff reading with always-on monitoring, targeting hypertension, the leading cardiovascular risk factor worldwide. The technology grew out of an earlier wireless implantable pressure sensor developed for glaucoma (intraocular pressure) monitoring.
ScoreData Corporation is a Palo Alto-based AI/ML company that helps consumer-facing businesses turn legacy and external data into real-time predictive decisions. Its ScoreFast platform builds and continuously updates machine learning models with minimal manual work, powering omni-channel customer engagement, caller-to-agent mapping, fraud detection, churn management and cross-sell for financial services, insurance and healthcare contact centers.
WellStack is a Madison, Wisconsin healthcare data platform that unifies fragmented clinical, financial, and operational data into a single governed source of truth. Built on a cloud-native Unified Data Model and a Snowflake foundation, it gives providers, payers, and data collaboratives out-of-the-box Patient/Member 360 views, modular Decision Hubs, and AI/ML-ready analytics - so healthcare organizations can predict, prevent, and personalize care without the years-long data-engineering slog.
Trek Health is a San Mateo-based healthtech company that turns federally mandated price-transparency data into negotiating leverage for hospitals and provider groups. Its AI-powered platform ingests, normalizes, and validates payer rate data from more than 120 commercial payers every quarter, then lets healthcare CFOs and contract teams benchmark their rates against the market, model negotiation scenarios, and identify revenue they're leaving on the table. Founded in 2022 by Dilpreet Sahota and Gopal Narayan, the company raised an $11M Series A led by Madrona in 2025 and serves 130+ provider customers.
Turquoise Health is a San Diego health-tech company building the operating system for healthcare contracts and payments. It turns the messy, hidden world of payer and provider pricing - machine-readable files, claims, contracts and Medicare benchmarks - into clear, auditable rates and AI-readable contracts, so that buying and paying for care could one day be as straightforward as any other transaction. More than 280 organizations, including major health systems, national payers, pharma companies and brokers, use the platform.
PatientIQ is a Chicago-based healthcare technology company that builds a cloud platform for systematically collecting, measuring, and analyzing patient-reported outcomes (PROs). Founded in 2016 by Matthew Gitelis, the company connects hospitals, health systems, private practices, and medical device makers on a single EHR-integrated system that turns outcomes data into actionable clinical and operational intelligence. PatientIQ has grown to serve more than 200 healthcare organizations and has collected outcomes data from over 1.4 million patients.
Avant-garde Health is a Boston-based healthcare data analytics company whose CareMeasurement platform helps hospitals, ambulatory surgery centers and physicians measure the true cost, quality and processes of surgical care - then turn those insights into measurable savings and better patient outcomes. Founded in 2014 out of value-based care research at Harvard Business School, the company applies Time-Driven Activity-Based Costing (TDABC) across EMR, financial, claims and patient-reported outcomes data to reveal what was previously invisible inside the operating room and the care pathway around it.
agilon health is a healthcare company that helps community primary care physicians move from fee-for-service medicine to value-based care for seniors. Through its Total Care Model, agilon gives physician partners the capital, technology, data and 100% downside risk protection they need to take on full financial responsibility for the total care of their Medicare patients. The company partners with physician groups across more than 30 communities and serves over half a million seniors on its platform.
Clarify Health Solutions is a San Francisco-based healthcare analytics company that maps hundreds of millions of patient journeys through its cloud-based Atlas Platform, helping payers, providers, and life sciences companies make smarter decisions about cost, care, and outcomes in the shift to value-based care.
House Rx is a San Francisco-based healthcare technology company that partners with specialty clinics to enable medically integrated dispensing (MID) - a model where physicians, pharmacists, nurses, and care coordinators work together as one unified team. Founded in 2021 by Flatiron Health veterans Ogi Kavazovic and Tesh Khullar, the company builds AI-enabled pharmacy management software that keeps specialty medications dispensed at the point of care, cutting average time-to-therapy from 15.5 days to 3.5 days and achieving 95% medication adherence. With $100M raised across Seed, Series A, and Series B rounds, House Rx serves 80 clinic sites, 1,000+ providers, and nearly 61,000 patients, processing approximately $1.5 billion in specialty prescriptions annually.