ophthalmology
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RHMM and the art of arriving before the launch
Shire had a new eye drug and a small ophthalmics team. RHMM helped prepare the professional audience - a revealing assignment for a company built around science, relationships, and getting the work done.
The Eye Drop That Refuses to Blink Away
A serial dry-eye entrepreneur who already sold one eye-care company to Johnson & Johnson is betting that the fix for dry eye is not a better drop - it is a drop that simply stays put.
Sun Pharma
Sun Pharma became India’s largest drugmaker by mastering generics. Now a portfolio of skin, eye and cancer medicines - and an audacious pending Organon deal - is changing what the company wants to be.
Beacon Therapeutics
Beacon Therapeutics is a clinical-stage ophthalmic gene therapy company building AAV-based treatments to preserve and restore sight for people with rare and prevalent retinal diseases that cause blindness. Formed in 2023 by Syncona around the assets of Applied Genetic Technologies Corp (AGTC) and complementary science from the University of Oxford, its lead program, laru-zova (AGTC-501), is a one-time gene therapy for X-linked retinitis pigmentosa now in registrational trials, with additional programs targeting geographic atrophy (dry AMD) and cone-rod dystrophy.
Character Biosciences
Character Biosciences is a precision medicine company developing targeted therapies for progressive polygenic diseases, starting in ophthalmology with age-related macular degeneration (AMD). By pairing human genetics with longitudinal clinical and retinal imaging data from thousands of consented patients - and layering AI-enabled biomarker analysis on top - Character reclassifies broad diagnoses into genetically defined subtypes so it can design drugs that target the root drivers of disease progression. Its lead programs, CTX114 (a complement inhibitor for geographic atrophy) and CTX203 (a lipid regulator to prevent progression to advanced AMD), are advancing toward the clinic on the strength of a Series B that grew past $110 million.
Fount Bio, Inc.
Fount Bio is a Somerville, Massachusetts life-science company that builds long-lasting hyaluronic acid (HA) matrices directly inside living tissue. Its proprietary Flī-HA platform uses Nobel-Prize-winning bioorthogonal (click) chemistry to deliver HA building blocks that self-assemble in situ into a biostable, high-molecular-weight matrix - overcoming the delivery and degradation barriers that have long forced HA to be injected as pre-formed filler. The lead product, Flī-Derm, is a needle-free liquid for aesthetic dermatology that reduced fine lines and wrinkles in a blinded clinical study and won IMCAS 2024's Innovation of the Year. The tunable platform extends toward ophthalmology, joints, mucosal tissue and women's health.
Neurotech Pharmaceuticals, Inc.
Neurotech Pharmaceuticals is a Cumberland, Rhode Island biotechnology company that develops long-acting therapies for chronic retinal diseases using its Encapsulated Cell Technology (ECT) platform - a tiny implant of genetically engineered cells that continuously secretes a therapeutic protein inside the eye. In March 2025 its lead product ENCELTO (revakinagene taroretcel-lwey, formerly NT-501/Renexus) became the first and only FDA-approved treatment for macular telangiectasia type 2 (MacTel), delivering ciliary neurotrophic factor (CNTF) to slow the loss of photoreceptors.
Allysta Pharmaceuticals, Inc.
Allysta Pharmaceuticals is a private, venture-backed, clinical-stage biopharmaceutical company developing first-in-class therapeutic peptides that target adiponectin signaling. Its lead compound, ALY688, is described as the first adiponectin receptor agonist to enter human testing, with anti-inflammatory, anti-fibrotic, cell-regenerative and metabolic properties. Allysta is advancing ALY688 as an ophthalmic solution for dry eye disease and as an extended/sustained-release formulation for systemic conditions such as NASH/MASH and Duchenne muscular dystrophy.
Shifamed
Shifamed is a Silicon Valley medical technology incubator founded in 2009 by serial entrepreneur Amr Salahieh. It combines human-centered design, in-house engineering, and R&D facilities to build medical device companies from concept to commercial launch, spinning out and incubating startups across cardiovascular, electrophysiology, and ophthalmology. Its portfolio and legacy companies have raised over $800M and produced multiple acquisitions by Boston Scientific, Abbott, Covidien, and Johnson & Johnson.
Vivid Vision
Vivid Vision is a San Francisco medical technology company that turns virtual reality headsets into tools for vision care. Founded in 2014 by programmer James Blaha, who built the first prototype to treat his own lazy eye, the company started with VR games for amblyopia and strabismus and now runs two lines: a clinical and at-home vision therapy suite used in clinics across 50+ countries, and Vivid Vision Perimetry (VVP), a VR-based visual field test being adopted as a digital endpoint in pharmaceutical clinical trials for glaucoma, AMD, and geographic atrophy.
PlenOptika
PlenOptika is a Cambridge, Massachusetts medical device company that makes QuickSee, a handheld autorefractor that measures a person's eyeglass prescription in about ten seconds using wavefront aberrometry and machine-learning algorithms. Spun out of the Madrid-MIT M+Vision fellowship in 2014, the company set out to close the gap on uncorrected refractive error, a problem affecting more than a billion people worldwide. Its portable, clinic-quality device has been used by vision professionals and NGOs on over 5 million patients in more than 45 countries - and even flew aboard SpaceX's Polaris Dawn mission as the first handheld autorefraction device used in space.
Myra Vision
Myra Vision is a Campbell, California medical device company developing the Calibreye Titratable Glaucoma Therapy Surgical System - a next-generation aqueous shunt with adjustable outflow channels that let surgeons fine-tune intraocular pressure in glaucoma patients non-invasively in the clinic, long after the implant goes in.
Adaptilens
Adaptilens is a pre-clinical biotechnology company in Newton, Massachusetts developing the first biomimetic accommodating intraocular lens (A-IOL) - a soft, flexible artificial lens that responds to the eye's natural focusing signal from the ciliary muscle. Founded by ophthalmologist Dr. Liane Clamen, the company aims to replace the cataract-clouded natural lens with one that restores clear vision across near, intermediate, and distance ranges without glasses, contacts, or the halos and glare common to multifocal alternatives. Adaptilens raised a $17.5M Series A in April 2024 to advance its A-IOL toward first-in-human trials.
Avisi Technologies
Avisi Technologies is a clinical-stage ophthalmic medical device company building VisiPlate, an ultrathin, nanotechnology-enabled aqueous shunt that drains excess fluid from the eye to lower pressure in glaucoma patients. Spun out of the University of Pennsylvania's Y-Prize program in 2017, the company is advancing VisiPlate through the FDA-cleared SAPPHIRE pivotal trial and has raised roughly $21.7M to date, including a $10.7M Series A in February 2026.
Intalight
Intalight is a US-based ophthalmic imaging company (the international brand of SVision Imaging / 视微影像, Luoyang, China) that builds high-speed swept-source OCT and OCT-angiography systems. Its flagship DREAM OCT platform images the whole eye in a single ultra-widefield scan, combining deep retinal penetration, anterior-segment imaging, biometry, and AI-driven segmentation for clinicians and researchers worldwide.
Kriya Therapeutics, Inc.
Kriya Therapeutics is a clinical-stage biopharmaceutical company building one-time, AAV-based gene therapies for prevalent chronic diseases of high unmet need. Founded in 2019 and headquartered in Morrisville, North Carolina with operations in Silicon Valley, Kriya pairs a proprietary, vertically integrated manufacturing and R&D engine with a pipeline spanning ophthalmology, metabolic disease, and neurology. Its bet: gene therapy shouldn't be reserved for the rare few, but engineered and manufactured at the scale and cost needed to reach millions.
Noveome Biotherapeutics, Inc.
Noveome Biotherapeutics is a Pittsburgh clinical-stage biopharmaceutical company built around ST266, a multi-targeted secretome of hundreds of biologically active proteins harvested from a novel population of amnion-derived cells. Rather than transplanting cells, Noveome delivers the healing signals those cells secrete - aiming to modulate inflammation, protect nerves, and accelerate tissue repair. Its lead program treats necrotizing enterocolitis, a devastating gut disease in premature infants, with additional pipeline work spanning ophthalmology, neurology, and dermatology.
Ollin Biosciences
Ollin Biosciences is an Austin-based clinical-stage biopharmaceutical company building a portfolio of best-in-disease therapies for vision-threatening eye diseases. Founded in 2023 and launched publicly in September 2025 with $100M in Series A financing, Ollin in-licenses validated drug candidates and races them through head-to-head trials against the market leaders. Its lead program, OLN324, is a VEGF/Ang2 bispecific antibody for wet age-related macular degeneration and diabetic macular edema that posted superior anatomic results versus Roche's blockbuster Vabysmo in a Phase 1b study.
ViaLase, Inc.
ViaLase, Inc. is a clinical-stage medical technology company in Aliso Viejo, California building the first femtosecond laser designed to treat primary open-angle glaucoma without cutting into the eye. Its ViaLuxe Laser System pairs micron-level, high-definition imaging with a femtosecond laser to perform a noninvasive, image-guided trabeculotomy - branded FLigHT - that creates a drainage channel through the trabecular meshwork to lower intraocular pressure. Founded in 2019 by femtosecond-laser pioneer Tibor Juhasz, the company has raised more than $115 million, earned a CE Mark in Europe, and begun a U.S. IDE clinical trial.
Luminopia
Luminopia is a commercial-stage digital therapeutics company that turns a child's favorite TV shows into FDA-cleared medicine for amblyopia (lazy eye). Children wear a VR headset for one hour a day, six days a week, and watch curated, real-time-modified episodes that retrain the brain to use both eyes together. Founded by Harvard dropouts and incubated at Boston Children's Hospital, Luminopia One became the first FDA-approved digital therapeutic for a neuro-visual disorder.
NGM Biopharmaceuticals
NGM Biopharmaceuticals is a private South San Francisco biotech translating biology into first-in-class medicines, anchored by its GDF15/GFRAL antagonist NGM120 in Phase 2 trials for cancer cachexia and hyperemesis gravidarum.