Two friends from Michigan turned a biodegradable cleaner and a handshake into the world's biggest direct-selling company. Seven decades later, Amway still refuses to sell a single share.
Abbott built a $44.3 billion business by showing up everywhere health becomes measurable - from a breakfast shake to a glucose curve to a repaired heart valve. Its breadth is the strategy, and the complication.
It taught a generation to count points and lean on each other. Then a weekly shot changed the math - so WeightWatchers went to the doctor.
Factor built a sizable business by shrinking dinner to a two-minute microwave job. Now the HelloFresh-owned brand is testing whether the same refrigerated tray can travel beyond the subscription box - into offices, campuses, sports partnerships and Target aisles.
The 96-year-old owner of Dove, Hellmann's and Knorr just cut its ice cream loose and bet everything on 30 brands. Inside the biggest reset in modern consumer goods.
Fitia is an AI-powered nutrition tracking and meal planning app built by two childhood friends from Peru. It turns the daily grind of counting calories into a personalized plan: users log food by photo, voice, text, or barcode, and Fitia adapts meal plans, macros, and grocery lists to their goals and food preferences. Backed by Y Combinator (S21), it has grown to more than 10 million users across 150+ countries and outranks incumbents like MyFitnessPal in downloads across Spain and much of Latin America.
UFIT is Singapore's largest independently owned health, fitness and sports community, combining personal training, group classes, physiotherapy, sports medicine, nutrition, podiatry and corporate wellbeing under one integrated roof. Founded in 2011 as an outdoor bootcamp in Fort Canning Park, it now runs multidisciplinary hubs across the city where coaches and clinicians collaborate through its 'Circle of Care' model to treat everyday clients like athletes in their own lives.
Berry Street is a New York-based digital health company that connects patients with registered dietitians for insurance-covered, virtual nutrition therapy while giving those dietitians an AI-enabled 'business-in-a-box' to run independent practices. Founded in 2023 by Noah Kotlove and Jesse Rose, the platform pairs a consumer marketplace - where most clients pay $0 out of pocket - with back-office tooling that handles insurance credentialing, claims, documentation and patient communication. It works with a network of more than 1,000 dietitians and 1,250-plus insurance plans, and raised a $50 million Series B in early 2025.
Culina Health is a virtual nutrition care company founded in 2020 by registered dietitians Vanessa Rissetto and Tamar Samuels. It pairs patients with credentialed registered dietitians for one-on-one, insurance-covered nutrition therapy delivered via telehealth across all 50 states. The company blends evidence-based clinical care with culturally affirming, multilingual support to treat conditions ranging from diabetes and heart disease to GI disorders and eating disorders, while partnering with major insurers, Medicare, and employers to make expert nutrition care accessible.
Helaina is a New York-based biotechnology company using precision fermentation to produce human-equivalent bioactive proteins. Its first commercial product, effera, is a human-identical lactoferrin made in yeast that matches the amino acid sequence of the protein found in mother's milk. Founded in 2019 by food scientist Laura Katz, Helaina sells effera as a B2B ingredient to consumer wellness and supplement brands, targeting women's health, gut health, active nutrition and healthy aging. The company has raised roughly $84 million in equity funding, including a $45 million Series B in 2024.
Performance Kitchen | Food Is Medicine® is an Austin, Texas company that produces chef-crafted, dietitian-approved Medically Tailored Meals designed to help manage chronic conditions such as diabetes, heart disease, and renal disease. Founded in 2011 as a healthy consumer food brand sold in more than 10,000 retail stores, the company pivoted to lead the Food Is Medicine movement, delivering ready-to-eat meals that are increasingly paid for by health insurers and delivered directly to members' homes. Led by Chairman and CEO Mark Walker, a CPA and founder of athlete-backed Dugout Ventures, Performance Kitchen operates nationwide production and distribution reaching roughly 98% of the U.S.
Zaya Care is a New York-based healthcare company building the largest network of in-network maternal and wellness specialists in the United States. It negotiates insurance contracts on behalf of independent practitioners - pelvic floor therapists, lactation consultants, dietitians, mental health therapists and acupuncturists - and handles credentialing, eligibility and billing so those providers can accept insurance without the administrative burden or financial risk of doing it alone. Inspired by the comprehensive European model of maternity care, Zaya gives small practices the leverage and efficiency of a large health system while letting them stay independent, and gives patients affordable, whole-person care beyond the standard OB-GYN visit.
ACTIVZ is a West Jordan, Utah-based health and wellness company that bills itself as the first direct-selling brand built around epigenetics - the idea that lifestyle and nutrition can influence how genes express themselves. Founded in 2017 by David Brown and Ryan Thompson, the company sells supplements (LINQ, AIRO, Optimend) and an anti-aging skincare line through a distributor network paired with an omnichannel e-commerce model. It launched first in Spanish-speaking Mexico before expanding to the US, Peru, Japan and beyond.
Ora Organic is an Austin-based direct-to-consumer wellness brand making plant-based, USDA Organic supplements - vegan protein powders, greens, probiotics, and vitamins - built around clean, third-party-tested ingredients with no synthetic additives. Founded in 2014 and later featured on Shark Tank, it grew from a founder's kitchen-table idea into a multi-product catalog spanning gut health, hormones, recovery, brain health, and skin.

WellTheory is a virtual autoimmune care platform founded in 2020 by Ellen Rudolph, Claire Rudolph, and Wallace Torres — all personally affected by autoimmune disease. The company pairs licensed registered dietitians and board-certified health coaches with advanced diagnostic testing to help the 50+ million Americans living with autoimmune conditions reduce symptoms and reclaim their lives. Members follow a 12-month personalized program covering nutrition, sleep, stress, and movement. Clinical outcomes show 92% of members reduce symptoms within four weeks, 85% cut ER visits within 16 months, and average annual healthcare savings of $5,181 per patient. Backed by $33.4M in total funding led by General Catalyst, WellTheory serves both individual members ($175/month) and self-insured employers and health plans like Sentara Health Plans.
Cheers (formerly Thrive+) is a Houston-based alcohol-related health and wellness company built around dihydromyricetin (DHM), a botanical extract studied for supporting the liver and reducing the after-effects of drinking. Founded by Brooks Powell after he encountered DHM research as a Princeton undergraduate, Cheers sells a line of science-backed supplements - Restore, Relief, Hydrate, Protect and Multi - direct-to-consumer, on Amazon, and in tens of thousands of retail locations. The company holds a U.S. patent on its formulation, has served more than a million customers, and frames its mission as helping people enjoy alcohol responsibly while protecting long-term health.
mindbodygreen is an independent lifestyle media and wellness company that pairs science-backed editorial content - articles, newsletters, podcasts and certification courses - with a direct-to-consumer line of supplements and personal care products. Founded in 2009 after a back injury pushed Jason Wachob toward yoga, the company has grown into one of the largest independent health-and-wellness platforms, reaching millions of monthly readers with a 360-degree approach that weaves together the mental, physical, spiritual, emotional and environmental sides of well-being.
Parsley Health is a functional-medicine telehealth provider founded in 2016 by physician Dr. Robin Berzin. It pairs in-depth diagnostics and biomarker testing with longitudinal, team-based care - doctors plus health coaches - to find and treat the root causes of chronic conditions like gut, autoimmune, hormonal, metabolic and mental-health issues, rather than just managing symptoms. Originally a cash-pay membership model with clinics in New York and Los Angeles, Parsley has shifted to a virtual-first national service and in 2026 became the first functional-medicine provider to accept insurance in-network nationwide, putting its care within reach of roughly 150 million insured Americans.
one.bio is a Sacramento biotechnology company that releases short-chain plant fibers and makes them flavorless, odorless, colorless and water-soluble so they can be added to food and drinks at high doses without changing taste or texture. Spun out of UC Davis, it pairs a fiber-mapping knowledgebase called the Glycopedia with a proprietary depolymerization process to turn long-chain plant carbohydrates - including agricultural byproducts - into bioactive fibers that feed the microbiome and support metabolic and immune health. The company raised a $27M Series A in December 2024 and in early 2026 launched its discovery platform, its first clinically validated ingredient (one.bio 01) and a consumer brand, GoodVice.
Foodsmart (formerly Zipongo) is a San Francisco-based telenutrition company that pairs registered dietitians with a food benefits marketplace to treat diet-related chronic disease and food insecurity. It serves more than 2.2 million members across employer plans, Medicaid managed care, Medicare Advantage and commercial insurers, and in 2024 raised $200M led by TPG's The Rise Fund to expand its 'Foodscripts' food-as-medicine programs with major U.S. health systems.
Signos is a San Francisco Bay Area digital health company pairing a continuous glucose monitor with an AI-driven app to help non-diabetic adults lose weight and improve metabolic health through real-time, personalized feedback on food, sleep, stress and exercise.
Vivoo is a San Francisco-based health tech company that makes at-home urine test strips analyzed via smartphone camera. Founded in 2017, the company offers a wellness platform that measures 8+ biomarkers — including hydration, vitamins, minerals, pH, ketones, and oxidative stress — and delivers personalized nutrition and lifestyle recommendations through a free mobile app. Backed by $19.4M in funding led by Tim Draper, Vivoo is sold at Target, Walmart, and Sam's Club, and has expanded to 100+ countries with a focus on making lab-grade health insights accessible to everyday consumers.