digital-therapeutics
(19)
Welldoc Spent 20 Years Turning a Diabetes App Into the Plumbing for AI-Powered Care
The Maryland company learned that FDA clearance was only the opening move. Its more durable play is connecting devices, care teams and everyday decisions - then selling that regulated intelligence through the institutions already paying for chronic care.
Naluri
Naluri is a Southeast Asian digital health company that helps employers and insurers predict, prevent and manage chronic and mental health conditions. Founded in Kuala Lumpur in 2017, it combines behavioural science, data science and licensed health coaches - psychologists, dietitians, fitness and financial coaches - inside a single app to deliver structured, clinically-informed care for conditions such as diabetes, heart disease, obesity, chronic stress, anxiety and depression. Its programmes span Employee Assistance (EAP), chronic disease management and crisis support, serving over 200 employer clients and more than one million members across the region.
Cognito Therapeutics, Inc.
Cognito Therapeutics is a Cambridge, Massachusetts clinical-stage neurotechnology company spun out of MIT that develops non-invasive, wearable therapy for neurodegenerative disease. Its lead product, Spectris, delivers precise gamma-frequency light and sound stimulation through connected glasses and headphones to evoke gamma brain oscillations, with the goal of slowing cognitive and functional decline in Alzheimer's disease. Spectris AD holds FDA Breakthrough Device Designation and is being evaluated in the HOPE Study, described as the largest medical device trial focused solely on Alzheimer's disease.
Huma
Huma is a London-based digital health technology company that builds a regulated, modular software platform used by hospitals, pharmaceutical companies and governments to run remote patient monitoring, 'hospital at home', companion apps and decentralized clinical trials. Founded in 2011 as Medopad and rebranded to Huma in 2020, it combines predictive algorithms, digital biomarkers and real-world data with a no-code Huma Cloud Platform so partners can launch regulated, disease- and device-agnostic health apps. Its Software as a Medical Device holds EU MDR Class IIb, US FDA Class II and UK MHRA registrations, and its technology has reached thousands of hospitals and tens of millions of patients worldwide.
Neuroglee Health
Neuroglee Health is a Boston-based digital health company building value-based, at-home dementia and cognitive care. It pairs a virtual interdisciplinary clinical team - advanced practice nurses, social workers, pharmacists and care navigators supervised by neurologists and geriatric psychiatrists - with evidence-based digital therapeutics to support patients with mild cognitive impairment through late-stage dementia and their care partners. Founded in 2020 by Aniket Singh Rajput, the company works with Mayo Clinic on its Neuroglee Connect platform and participates in the CMS GUIDE Model to deliver comprehensive, longitudinal dementia care to Medicare beneficiaries at no cost to families.
Pelago
Pelago is a virtual clinic for substance use management, delivering physician-led, evidence-based care for tobacco, alcohol, opioid and other substance use. Founded in 2017 as Quit Genius by three Imperial College London physicians, the company combines cognitive behavioral therapy, medication-assisted treatment and at-home monitoring tools into a program sold to employers, health plans and pharmacy benefit managers. Pelago says it has supported more than 750,000 members and validates its approach with 13 peer-reviewed studies.
WONZ Technology
WONZ Technology is a digital health company built around one goal: helping the world's roughly 1.5 billion smokers cut their exposure to the harmful byproducts of combustion. Founded by Xin (Steven) Du in 2020, WONZ pairs hardware - heat-not-burn smart devices sold under the CIGPAL brand - with digital intervention software, an exhaled-CO tester, and AI-guided coaching. Its proprietary WHC (WONZ Heat Currents) thermal distillation technology is designed to reduce inhalation of more than 90% of the main harmful substances in cigarette smoke while easing cravings and withdrawal. The company holds over 100 patents and has raised more than US$13 million from investors including XVC.
Arcade Therapeutics
Arcade Therapeutics is a New York-based digital therapeutics company that builds clinically validated mobile games to treat mental illness. Founded by healthcare entrepreneur Raj Amin and neuroscientist Tracy Dennis-Tiwary, the company embeds a research-backed technique called attention bias modification into engaging games, starting with StarStarter for anxiety. Its lead prescription product, ABM-01, is pursuing FDA submission as one of the first game-based treatments for social anxiety disorder, with a pipeline extending to depression, addiction, and other conditions.
Constant Therapy
Constant Therapy is a Boston-area digital health company that turns speech, language, and cognitive rehabilitation into an AI-personalized app. Spun out of Boston University's Aphasia Research Laboratory in 2012, its platform delivers more than 100,000 evidence-based exercises across 80-plus task categories to people recovering from stroke, traumatic brain injury, aphasia, dementia, and other neurological conditions - and to the clinicians who treat them. A patented NeuroPerformance Engine adapts each session to the individual, extending therapy beyond the clinic and into daily home practice.
Hopelab
Hopelab is a San Francisco social innovation lab and impact investor founded in 2001 by Pam Omidyar. It works at the intersection of technology and adolescent mental health, combining behavioral science, youth co-design, and research to advance the well-being of young people ages 10-25, with a focus on BIPOC and LGBTQ+ youth. Best known for the cancer video game Re-Mission, Hopelab now runs research programs, youth fellowships, and Hopelab Ventures, which has invested more than $12 million across roughly 20 youth mental health startups.
Roga
Roga is a neurotech company building a non-invasive vagus nerve stimulation wearable paired with an AI-guided meditation app to reduce stress and burnout. Founded by two people who each managed clinical anxiety, the discreet behind-the-ear device sends gentle electrical pulses to calm the nervous system, while the companion app personalizes meditation and tracks progress. Based in Los Angeles and Toronto, Roga sells direct to consumers and to employers running workplace wellness programs.
Adhera Health
Adhera Health builds an empathic AI 'precision digital companion' for families managing pediatric chronic conditions - growth hormone therapy, type 1 diabetes, childhood obesity, autoimmune and oncology cases. The platform pairs behavioral science with personalization technology to support caregivers, improve treatment adherence, and surface what happens between clinical visits.
Swing Therapeutics, Inc.
Swing Therapeutics is a San Francisco digital therapeutics company building software-based treatments for chronic illness. Its flagship product, Stanza, is the first FDA-cleared prescription digital therapy for fibromyalgia, delivering acceptance and commitment therapy (ACT) through a smartphone in roughly 15 minutes a day. The company also operates Swing Care, a telehealth clinic that prescribes and supports the therapy across multiple states.
Progentec Diagnostics, Inc.
Progentec Diagnostics is an Oklahoma City company building blood-based biomarker tests and digital health tools for autoimmune diseases, starting with lupus. Its lead product, the aiSLE DX Flare Risk Index, uses an 11-biomarker algorithm to predict a lupus flare up to 12 weeks before it happens, giving rheumatologists a chance to intervene early. Spun out of research tied to the Oklahoma Medical Research Foundation, the company pairs lab science with patient-facing tools like the LupusCorner community to move autoimmune care from reactive to proactive.
Curavit Clinical Research
Curavit Clinical Research is a Boston-based, all-virtual Contract Research Organization (CRO) that designs and runs decentralized clinical trials. Through its Virtual Clinical Site and STRATUS platform, Curavit recruits, enrolls, and monitors diverse patient populations remotely - eliminating physical site infrastructure and travel while improving data quality. The company specializes in trials for digital therapeutics (DTx) and partners with sponsors and existing CROs to fix the execution layer of clinical research, accelerating timelines and lowering costs.
Luminopia
Luminopia is a commercial-stage digital therapeutics company that turns a child's favorite TV shows into FDA-cleared medicine for amblyopia (lazy eye). Children wear a VR headset for one hour a day, six days a week, and watch curated, real-time-modified episodes that retrain the brain to use both eyes together. Founded by Harvard dropouts and incubated at Boston Children's Hospital, Luminopia One became the first FDA-approved digital therapeutic for a neuro-visual disorder.
Medisafe
Medisafe is a digital health company that turns the everyday struggle of taking pills on time into a behavior-driven engagement platform. Born from a near-fatal insulin overdose in the founders' own family, it began as a free virtual pillbox app and grew into an enterprise platform - anchored by Medisafe Maestro and its Just-in-Time Interventions (JITI) engine - that pharmaceutical companies use to keep patients on therapy. With more than 13 million users worldwide and 4+ billion doses tracked, Medisafe sits at the intersection of consumer mobile health and the multibillion-dollar problem of medication non-adherence.
Omada Health
Omada Health is a publicly traded (Nasdaq: OMDA) virtual chronic care company that uses behavioral science, connected devices, AI tools, and human care teams to help people manage prediabetes, diabetes, hypertension, high cholesterol, musculoskeletal conditions, and weight - including support for members on GLP-1 medications. Founded in 2011 in San Francisco, it sells to employers, health plans, and pharmacy benefit managers, serving roughly 2,000-plus customers and more than 886,000 members.
Hello Heart
Hello Heart is a Menlo Park-based digital health company exclusively focused on cardiovascular health. Founded in 2013, it offers an AI-powered mobile app paired with a connected blood pressure monitor and smart pill box that helps members understand, track, and improve their heart health. Deployed through employers, health plans, and Medicare Advantage programs, Hello Heart has served users at 150+ Fortune 500 companies and government organizations. Independent peer-reviewed studies - including a JAMA study of 28,000+ participants - show that 84% of high-risk users reduced blood pressure over three years, with average medical cost savings exceeding $1,700 per enrolled member per year. The company has raised $148.5 million in total funding, most recently a $70 million Series D in May 2022.