Circe (Circe Bioscience) is a Boston-based climate biotech company that engineers microbes to eat carbon dioxide and build valuable molecules - fats, oils, sugars, plastics and fuels - using only CO2, water and electricity. Spun out of Harvard's Wyss Institute in 2021, its gas-fermentation platform consumes roughly 3 kilograms of CO2 for every kilogram of oil it produces, making the process carbon-negative. The company has made the world's first chocolate using fermentation-derived cocoa butter and, in September 2024, raised a $5M seed round to open a pilot plant in Waltham, Massachusetts.
Terragia Biofuel is a New Hampshire climate-tech startup turning non-food plant waste into cost-competitive, low-carbon ethanol using engineered thermophilic bacteria. Its consolidated bioprocessing (CBP) approach skips the expensive enzymes and thermochemical pretreatment that have historically sunk cellulosic biofuel economics, promising an 8x shorter payback period at 10x smaller scale. Spun out of Professor Lee Lynd's decades of research at Dartmouth, Terragia aims to make biofuels for hard-to-electrify transport - aviation, shipping, and long-haul trucking - that can actually compete with fossil fuels.
Mango Materials is a biomanufacturing company that converts waste methane - the same gas that vents from landfills and wastewater plants - into biodegradable polyhydroxyalkanoate (PHA) pellets sold under the YOPP brand. The pellets replace conventional plastics in fibers, films, rigid goods, and 3D-printing feedstock, and they fully biodegrade in soil, freshwater, and marine environments.
Shannon Nangle is a microbe-wrangling scientist turned CEO who co-founded Circe Bioscience to make fats, oils, and even chocolate out of thin air. Her company feeds carbon dioxide, water, and electricity to engineered microbes that grow like plants and excrete valuable molecules, producing food and industrial ingredients in a carbon-negative way. Spun out of Harvard's Wyss Institute in 2021, Circe made what it calls the world's first gas-fermentation-derived chocolate and has raised over $17 million to scale a manufacturing process Nangle spent six years building.
CleanFiber makes high-performance, carbon-negative cellulose building insulation from recycled corrugated cardboard. Using a proprietary wet separation and liquid borate infusion process, it produces a cleaner, lower-dust insulation that performs better than legacy newsprint-based cellulose. Based in Buffalo, New York, the company has scaled rapidly since opening commercial production in 2020 and was named the #1 fastest-growing manufacturing company in America on the 2024 Inc. 5000.