A Stanford-founded health-AI company that predicts each patient's odds of a live birth - then turns that certainty into affordability.
Machine learning • Reproductive medicine • Founded 2009
For most people considering in vitro fertilization, the hardest number to find is the one that matters most: what are my chances? Clinics have long answered with age - a woman's birth year standing in for her biology. Univfy, a health-AI company based in Los Altos, California, was built on the finding that age alone explains only about half of the variation in whether IVF ends in a live birth. The rest, the company argues, is hiding in data that machine learning can read.
Founded in 2009 by Dr. Mylene Yao, a board-certified OB/GYN and reproductive endocrinologist, and Prof. Wing H. Wong, a Stanford statistician elected to the US National Academy of Sciences, Univfy analyzes an individual's full fertility profile - age, BMI, Day 3 FSH, AMH, semen analysis, and reproductive history - against thousands of real IVF cycles. The output is a personalized probability of having a baby, delivered before a patient decides whether to begin treatment.
The company's core claim is not that it predicts better in the abstract, but that it predicts better for a given clinic. Univfy builds center-specific models, on the logic that a fertility center's patient population rarely matches the national average.
"Univfy makes IVF success and costs more predictable so you can make confident decisions about your treatment."
In April 2025, Univfy published a validation study in Nature Communications, analyzing 4,645 patients across six fertility centers. Its center-specific models were compared head-to-head with the US national registry-based model. One result stood out: the models correctly flagged a group of patients as having a live-birth probability of 75% or higher - a group whose actual live-birth rate came in at 81%. The national registry model identified none of them.
Univfy is a B2B company that reaches patients through their clinics. Its customers are fertility centers and reproductive endocrinologists across a US provider network, and increasingly the health plans and employers now offering fertility benefits. Named clinic partners include Piedmont Reproductive Endocrinology Group, Dallas IVF, and GENESIS Fertility.
The problems it attacks are the two that make IVF hard: uncertainty and cost. A single cycle can run tens of thousands of dollars with no guarantee, and patients often decide with population averages instead of their own odds. Univfy's answer is prediction up front, and money-back structure on the back end.
A personalized PreIVF report replaces "the average patient's odds" with their own, before committing to a cycle.
Center-specific models let clinics counsel accurately and offer affordability programs to more of their patients.
Health plans and employers get predictability on fertility treatment success and costs for their members.
An online report translating a full fertility profile into a personalized probability of a live birth across the first cycles.
A scalable engine that builds center-specific prediction models, peer-reviewed to outperform national registry-based models.
Refund/warranty programs designed for clinics that can qualify 50-80% of patients and refund 30-80% of fees if no live birth occurs.
Platform services bringing cost transparency and predictability to health plans and employers.
A "find a fertility doctor" directory connecting patients to clinics offering Univfy-powered prognostics and affordability.
Free IVF calculators exist - most run on national registry data or age alone. Univfy's separation is threefold: it uses a full clinical profile rather than a single variable, it trains a model per center rather than one national average, and it publishes. The company has a research trail stretching from a 2008 PLoS ONE paper on embryo "phenotypes" to the 2025 Nature Communications validation, plus a global patent portfolio.
The business model follows from the accuracy. Because the predictions are reliable enough to price against, Univfy can license the platform and PreIVF reports to clinics and design refund warranties around them - a structure that only works if you can tell, in advance, who is likely to succeed. Prediction, in other words, is what makes the financing possible.
"Age alone explains only about half of the variation in IVF success."
Stanford research defines human embryo "phenotypes" by cohort-specific prognostic factors (PLoS ONE).
Dr. Mylene Yao and Prof. Wing H. Wong launch the company to commercialize AI-driven IVF prediction.
Published models for personalized first-cycle IVF success underpin the PreIVF report.
Raised $6M and expanded the US provider network and refund programs.
Raised $6M to extend platform services to health plans and employers.
Center-specific models shown to outperform the US national registry model.
Univfy uses machine learning to give IVF patients a personalized, center-specific probability of having a live birth, and powers patient counseling, fertility benefits, and IVF refund programs for clinics, employers, and health plans.
It was founded in 2009 by Dr. Mylene Yao, a board-certified OB/GYN and reproductive endocrinologist (CEO), and Prof. Wing H. Wong, a Stanford statistician and National Academy of Sciences member (Scientific Advisor).
Univfy found that age explains only about half of the variation in IVF success. Its models use a full fertility profile and clinic-specific data, and were shown roughly 1,000x more powerful than age-based estimates and superior to the US national registry model in peer-reviewed research.
It's a refund/warranty program Univfy designs for fertility centers using its predictions; because the predictions are accurate, clinics can qualify 50-80% of patients and refund 30-80% of the fee if no live birth results.
Yes. Univfy has a long publication record, most recently a 2025 Nature Communications study validating its center-specific models across 4,645 patients at six clinics.