Breaking: Univfy validated in Nature Communications (2025) Age explains only ~50% of IVF success variation PreIVF tests ~1,000x more powerful than age-based estimates Refund programs can qualify 50-80% of patients Founded 2009 by Stanford researchers $12M+ raised across Series A & B Breaking: Univfy validated in Nature Communications (2025) Age explains only ~50% of IVF success variation PreIVF tests ~1,000x more powerful than age-based estimates Refund programs can qualify 50-80% of patients Founded 2009 by Stanford researchers $12M+ raised across Series A & B
Company Dossier Health · AI · Femtech Los Altos, California

Univfy reads the other half of the IVF story.

A Stanford-founded health-AI company that predicts each patient's odds of a live birth - then turns that certainty into affordability.

Machine learning • Reproductive medicine • Founded 2009

Univfy logo
THE SUBJECT. The Univfy wordmark. Behind it: a decade of NIH-funded embryo research at Stanford, a global patent portfolio, and one stubborn question - why counsel IVF patients on age alone?
2009
Founded
4,645
Patients in 2025 study
50-80%
Patients refund-eligible
$12M+
Total funding raised

Turning IVF from a coin flip into a calculation

For most people considering in vitro fertilization, the hardest number to find is the one that matters most: what are my chances? Clinics have long answered with age - a woman's birth year standing in for her biology. Univfy, a health-AI company based in Los Altos, California, was built on the finding that age alone explains only about half of the variation in whether IVF ends in a live birth. The rest, the company argues, is hiding in data that machine learning can read.

Founded in 2009 by Dr. Mylene Yao, a board-certified OB/GYN and reproductive endocrinologist, and Prof. Wing H. Wong, a Stanford statistician elected to the US National Academy of Sciences, Univfy analyzes an individual's full fertility profile - age, BMI, Day 3 FSH, AMH, semen analysis, and reproductive history - against thousands of real IVF cycles. The output is a personalized probability of having a baby, delivered before a patient decides whether to begin treatment.

The company's core claim is not that it predicts better in the abstract, but that it predicts better for a given clinic. Univfy builds center-specific models, on the logic that a fertility center's patient population rarely matches the national average.

"Univfy makes IVF success and costs more predictable so you can make confident decisions about your treatment."

- Univfy, company mission

What the peer review actually showed

In April 2025, Univfy published a validation study in Nature Communications, analyzing 4,645 patients across six fertility centers. Its center-specific models were compared head-to-head with the US national registry-based model. One result stood out: the models correctly flagged a group of patients as having a live-birth probability of 75% or higher - a group whose actual live-birth rate came in at 81%. The national registry model identified none of them.

Patients correctly assigned high live-birth probability

Share of patients flagged at ≥75% live-birth probability · 6-center study, n=4,645
Univfy center-specific model11% flagged → 81% real birth rate
Univfy
US national registry model0% flagged
Source: Nature Communications (2025), "Machine learning center-specific models show improved IVF live birth predictions over US national registry-based model." Bars illustrate relative flagging; figures as reported.

Who Univfy is really for

Univfy is a B2B company that reaches patients through their clinics. Its customers are fertility centers and reproductive endocrinologists across a US provider network, and increasingly the health plans and employers now offering fertility benefits. Named clinic partners include Piedmont Reproductive Endocrinology Group, Dallas IVF, and GENESIS Fertility.

The problems it attacks are the two that make IVF hard: uncertainty and cost. A single cycle can run tens of thousands of dollars with no guarantee, and patients often decide with population averages instead of their own odds. Univfy's answer is prediction up front, and money-back structure on the back end.

Patients

Decide with data

A personalized PreIVF report replaces "the average patient's odds" with their own, before committing to a cycle.

Clinics

Grow responsibly

Center-specific models let clinics counsel accurately and offer affordability programs to more of their patients.

Payers

Price transparency

Health plans and employers get predictability on fertility treatment success and costs for their members.

What Univfy actually ships

2013

Univfy PreIVF Report

An online report translating a full fertility profile into a personalized probability of a live birth across the first cycles.

2025

Univfy AI/ML Platform

A scalable engine that builds center-specific prediction models, peer-reviewed to outperform national registry-based models.

2018

Univfy-Powered Refund Programs

Refund/warranty programs designed for clinics that can qualify 50-80% of patients and refund 30-80% of fees if no live birth occurs.

2021

Fertility Benefits for Payers

Platform services bringing cost transparency and predictability to health plans and employers.

2018

Provider Network

A "find a fertility doctor" directory connecting patients to clinics offering Univfy-powered prognostics and affordability.

Why it isn't just another calculator

Free IVF calculators exist - most run on national registry data or age alone. Univfy's separation is threefold: it uses a full clinical profile rather than a single variable, it trains a model per center rather than one national average, and it publishes. The company has a research trail stretching from a 2008 PLoS ONE paper on embryo "phenotypes" to the 2025 Nature Communications validation, plus a global patent portfolio.

The business model follows from the accuracy. Because the predictions are reliable enough to price against, Univfy can license the platform and PreIVF reports to clinics and design refund warranties around them - a structure that only works if you can tell, in advance, who is likely to succeed. Prediction, in other words, is what makes the financing possible.

"Age alone explains only about half of the variation in IVF success."

- The finding at the core of Univfy's platform

From Stanford lab to peer-reviewed platform

'08

The founding science

Stanford research defines human embryo "phenotypes" by cohort-specific prognostic factors (PLoS ONE).

'09

Univfy founded

Dr. Mylene Yao and Prof. Wing H. Wong launch the company to commercialize AI-driven IVF prediction.

'13

Personalized first-cycle prediction

Published models for personalized first-cycle IVF success underpin the PreIVF report.

'18

Series A & provider network

Raised $6M and expanded the US provider network and refund programs.

'21

Series B for benefits

Raised $6M to extend platform services to health plans and employers.

'25

Validated in Nature Communications

Center-specific models shown to outperform the US national registry model.

Univfy at a glance

Legal name
Univfy Inc.
Headquarters
Los Altos, California, USA
Founders
Dr. Mylene Yao & Prof. Wing H. Wong
Team size
~9 employees
Latest funding
$6M Series B (Dec 2021)
Category
Health · AI · Femtech · SaaS

People also ask

What does Univfy do?

Univfy uses machine learning to give IVF patients a personalized, center-specific probability of having a live birth, and powers patient counseling, fertility benefits, and IVF refund programs for clinics, employers, and health plans.

Who founded Univfy and when?

It was founded in 2009 by Dr. Mylene Yao, a board-certified OB/GYN and reproductive endocrinologist (CEO), and Prof. Wing H. Wong, a Stanford statistician and National Academy of Sciences member (Scientific Advisor).

How is Univfy different from age-based IVF calculators?

Univfy found that age explains only about half of the variation in IVF success. Its models use a full fertility profile and clinic-specific data, and were shown roughly 1,000x more powerful than age-based estimates and superior to the US national registry model in peer-reviewed research.

What is a Univfy-Powered IVF Refund Program?

It's a refund/warranty program Univfy designs for fertility centers using its predictions; because the predictions are accurate, clinics can qualify 50-80% of patients and refund 30-80% of the fee if no live birth results.

Has Univfy's technology been scientifically validated?

Yes. Univfy has a long publication record, most recently a 2025 Nature Communications study validating its center-specific models across 4,645 patients at six clinics.

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