Hamish McKenzie is the New Zealand-born co-founder and Chief Writing Officer of Substack, the subscription newsletter platform that has fundamentally reshaped how writers monetize their work. A former journalist and Tesla lead writer who wrote a book about Elon Musk's EV revolution, McKenzie pivoted from covering disruption to causing it - co-founding Substack in 2017 with Chris Best and Jairaj Sethi. Today the platform hosts over 50,000 earning creators and has raised $213 million total funding including a $100M Series C. McKenzie hosts The Active Voice podcast, delivered a TED2025 talk on the future of media, and is writing a book called 'How to Save the Media' due in 2026.
Don Vaughn, Ph.D. is the Co-Founder and CEO of Ampa Health, a Palo Alto-based neurotechnology company building FDA-cleared portable TMS (transcranial magnetic stimulation) devices that compress 36 days of depression treatment into a single day. A Stanford-educated physicist turned UCLA neuroscientist, Vaughn has built a career at the intersection of brain science, machine learning, and accessibility - detoured, notably, through a DJ career that landed him a #28 iTunes Dance chart hit featuring Nick Lachey. His TEDx talk on neurohacking has surpassed one million views. Ampa raised an oversubscribed $8.5M pre-A round in October 2025, achieved FDA clearance for its Ampa One device in February 2025, and is targeting 5,000 patient remissions by end of 2026 - with a long-term audacious goal of a billion remissions in ten years.
Anne-Laure Le Cunff, PhD is a French-Algerian neuroscientist, entrepreneur, and author based in London. After leaving a marketing career at Google, she founded Ness Labs - a bootstrapped newsletter and community focused on science-backed mindful productivity - while simultaneously earning her MSc and PhD in Applied Neuroscience at King's College London. Her 2025 book 'Tiny Experiments' (Penguin Random House) proposes replacing linear goal-setting with a circular, experimental approach to growth. As a UKRI-funded postdoctoral research fellow at King's College London, she studies the evolutionary neuroscience of curiosity and has proposed the 'Hypercuriosity Theory of ADHD'. Ness Labs has grown to 120,000+ newsletter subscribers and a paid community of 2,000+ members.
Isaac Saul is the founder and editor of Tangle, an independent nonpartisan politics newsletter with 500,000+ subscribers in 60+ countries. A former newspaper editor who contributed to CNN, TIME, HuffPost, and Vox, Saul launched Tangle in 2019 to fight news polarization by presenting the best arguments from left, right, and center on the day's biggest political debates. He's a Shorty Award winner, TED speaker, and one of the most trusted voices in independent political media.
Laura Nolan is a Principal Engineer at Stanza Systems, a veteran Site Reliability Engineer, and one of tech's most credible voices on autonomous weapons ethics. After five years at Google - where she contributed to the seminal O'Reilly SRE book and resigned over Project Maven - and seven years at Slack as Senior Staff Engineer, she brings deep technical authority to both the reliability engineering world and the global debate over killer robots. Based in rural Ireland, she speaks at SREcon, QCon, and TED stages alike, writes the Responsible Computing newsletter on Substack, and holds seats on the USENIX Board and the SREcon Steering Committee.