Stephen Larson is a neuroscientist and entrepreneur who co-founded OpenWorm, the open-science effort to build the first complete digital organism by simulating the 302-neuron nervous system of the roundworm C. elegans. He is co-founder and CEO of MetaCell, a life-science software company that helps pharmaceutical firms and research institutions visualize, analyze, and collaborate on complex biological data. Trained at MIT in computer science and AI and at UC San Diego in neuroscience, he sits at the intersection of code and biology, betting that understanding a worm in silico is a first step toward understanding the human brain.
Zeromatter builds the simulation infrastructure that autonomous-systems companies use to develop, test and validate their products before they ever touch the real world. Founded by former Tesla Autopilot simulation lead Ian Glow, its platform combines high-fidelity sensor simulation, automatic environment generation, multi-agent co-simulation frameworks, execution infrastructure and developer tooling into one system - aimed at making simulation a default tool for autonomy, aerospace, automotive, agriculture, drones and green energy.
Arena Physica is a New York-based AI company building 'electromagnetic superintelligence' - AI systems grounded in applied physics that accelerate the design, testing, and optimization of advanced hardware. Its Atlas platform and Heaviside foundation model predict electromagnetic behavior from geometry in milliseconds, claiming roughly 800,000x faster results than commercial solvers, and are used by hardware leaders across semiconductors, aerospace, automotive, medical devices, and defense.
Synopsys is the quiet giant behind the world's chips. Its electronic design automation (EDA) software, semiconductor IP, and AI-driven design tools are used to design and verify nearly every advanced silicon chip on the planet - from smartphone processors to AI accelerators. Founded in 1986 by Aart de Geus and led today by CEO Sassine Ghazi, the Sunnyvale company turned the impossibly hard task of laying out billions of transistors into a software problem, and now layers AI on top of it. Its 2025 acquisition of simulation leader Ansys pushed it deeper into multiphysics and systems engineering.
Rescale is a San Francisco-based digital engineering platform that turns high-performance computing into an on-demand cloud utility. Founded in 2011 by ex-Boeing engineer Joris Poort and Adam McKenzie, it gives scientists and engineers at companies like Samsung, Arm, General Motors Motorsports, and the U.S. Department of Defense a single workbench for simulation, AI physics, and multi-cloud orchestration.
Frenetic is a Madrid-born deep-tech company building AI-powered software and a manufacturing service for custom magnetic components - the unglamorous transformers and inductors at the heart of every power supply, EV charger, and electrified machine. Their platform compresses what used to take months of trial-and-error into days of simulation, and ships physical samples in roughly a week.
Tammie Siew is a General Partner and Co-Founder at Pebblebed, a San Francisco-based deep tech venture capital firm focused on foundational infrastructure—AI simulation engines, robot operating systems, developer platforms, and formal verification systems. A Cornell-educated economist and literature scholar who spent years investing at Sequoia Capital Singapore before co-founding a healthcare startup, she brings a rare operator-investor lens to backing the infrastructure layer of next-generation technology. Pebblebed's Fund II closed at $125M in 2024, with roughly 35 investments backing companies like Augment Code, OpenMind, Zeromatter, Lemurian Labs, and Logical Intelligence.
Ian Glow is the co-founder and CEO of Zeromatter, a Mountain View-based simulation platform that lets robotics, aerospace, and autonomy teams build, test, and train anything in virtual environments. He previously helped pioneer Tesla's Autopilot simulation infrastructure - working as Manager of Autopilot Simulation - before striking out to democratize simulation tooling for the broader industry. Zeromatter has raised $45M and assembled a 75+ person team of engineers from Tesla, Cruise, Nvidia, Google, Microsoft, Activision, and id Software.
Charles Wong is the CEO and Co-Founder of Bifrost AI, a San Francisco-based generative 3D data platform that lets robotics, aerospace, maritime, and industrial teams train and test AI models in hours instead of months. A Forbes 30 Under 30 honoree from Singapore, Wong built Bifrost after working on AI perception models for autonomous vehicles at NuTonomy (an MIT spinout). Bifrost has raised $13.7M in total funding, counts NASA JPL and the U.S. Air Force among its clients, and generates synthetic datasets for some of the world's most demanding physical-world AI challenges - from Mars rover navigation to maritime collision avoidance.
Hardik Kabaria is Co-Founder and CEO of Vinci4D.ai (now getvinci.ai), a Palo Alto-based AI company building a physics foundation model that makes hardware simulation 1000x faster than traditional finite element analysis. A Stanford PhD in Mechanics and Computation, he spent eight years at Carbon - the 3D printing unicorn - rising from software engineer to CXO before founding Vinci in 2023. His company emerged from stealth in December 2025 with $46M raised from Xora Innovation, Khosla Ventures, and Eclipse, already deployed with three leading semiconductor manufacturers and validated by over half the world's top 20 chip companies.
Joon Sung Park is the CEO and Co-founder of Simile, a Stanford-spinout AI company that raised $100M Series A in February 2026 to build digital twins that simulate human behavior and predict consumer decisions. A PhD in Computer Science from Stanford (2025), Park pioneered the concept of 'generative agents' - AI actors with memory, reflection, and planning capabilities - through a landmark 2023 paper that earned a Best Paper Award at UIST and became one of the most-cited works in HCI. Before launching Simile, he was an oil painter trained in hyper-realism, a background that infuses his research with a rare sensitivity to what makes humans human. His digital-twin platform has already signed CVS Health and Telstra as customers, and his model correctly forecast 8 out of 10 questions asked at a real earnings call.
Nicolai 'Nic' Ouporov is Co-Founder and CEO of Fleet AI, a startup building reinforcement learning training environments - or 'RL gyms' - that let AI agents practice operating real software tools like Salesforce and Excel before deployment. Fleet raised ~$45M total and grew from $1M to $60M+ annualized revenue in under a year. Nic is also a 3x YoungArts Award winner in photography and visual arts, a former pre-professional ballet dancer trained at Boston Ballet and San Francisco Ballet, and a QuestBridge Scholar from Columbia University. He previously served as Founding Engineer at Respell (acquired by Salesforce in 2024) and published AI research at Stanford's Robotics and Embodied AI Lab.
Kevin McNamara is the Founder and CEO of Parallel Domain, a San Francisco-based synthetic data and simulation platform that has raised $43.9M to power the next generation of AI perception systems. With a rare career arc spanning Pixar's animation pipeline, Microsoft's Xbox game studios, and Apple's secretive autonomous systems group, McNamara distilled a career of building virtual worlds into a platform that lets autonomous vehicle, drone, and robotics companies train their AI on infinite synthetic scenarios - accelerating ML development cycles by over 180x compared to real-world data collection.