protein-design
(9)
Pando Bioscience
Pando Bioscience is an AI-driven synthetic biology company that engineers better enzymes for the pharmaceutical and diagnostics industries. It pairs a generative-AI design model with an ultra-high-throughput 'one-pot' screening platform that tests roughly 1,000 times more enzyme variants - about 75% faster and 80% cheaper than conventional methods - compressing the design-build-test-learn cycle to about one month. Founded in 2022 by former Ginkgo Bioworks scientists Will Cao and Yang Wang, Pando both improves customers' enzymes and builds its own proprietary enzyme assets, such as the Saiyan-Phi29 polymerase.
Aizen Therapeutics
Aizen Therapeutics is a San Diego, AI-driven biotech spun out of Caltech that designs Mirror Peptides - synthetic drugs built entirely from D-amino acids, the mirror image of the L-amino acids that make up natural proteins. Its DaX platform pairs generative AI with structural biology to design these molecules from scratch, aiming for drugs with the potency of biologics but greater stability, lower immunogenicity, and the potential to be taken orally. The company emerged from stealth in November 2024 with a $13M seed round.
Ajay Kshatriya
Ajay Kshatriya is the CEO and co-founder of Aizen Therapeutics, a San Diego biotech that spun out of Caltech to build 'Mirror Peptides' - drugs made entirely of D-amino acids, the mirror image of the proteins nature uses. The company launched from stealth in November 2024 with $13M and a generative-AI platform called DaX. Before Aizen, Ajay founded and ran Biota, an environmental genomics company acquired by Novozymes in 2021 after creating roughly $400M in economic value and saving 1.2 billion gallons of water for industrial clients. A UC Berkeley and Stanford-trained chemical engineer who began his career at Genentech and learned company-building as a seed investor at XSeed Capital, he now also invests in Caltech science startups as a partner at Wilson Hill Ventures.
Outpace Bio
Outpace Bio is a Seattle biotech using AI-powered de novo protein design to program immune cells - especially CAR T cells - that can recognize and destroy solid tumors while limiting harmful side effects. Spun out of Lyell Immunopharma in 2021 by Institute for Protein Design alumni, the company has raised roughly $199M and is advancing its lead candidate, OPB-101, a mesothelin-targeted CAR T therapy for platinum-resistant ovarian cancer, toward the clinic.
Deniz Kavi
Deniz Kavi is the co-founder and CEO of Tamarind Bio, a San Francisco company that turns hundreds of complex computational-biology models - AlphaFold, RFdiffusion, OpenFold and more - into a point-and-click web tool and API so scientists can design drug candidates without writing code or wrangling cloud infrastructure. A Stanford computer-science graduate who did computational-biology research and engineered software at Stanford School of Medicine, he started the company in 2023 with co-founder Sherry Liu, went through Y Combinator's W24 batch, and in February 2026 raised a $13.6M Series A led by Dimension Capital. Tamarind now serves 10,000+ scientists, including 8 of the top 20 global pharma companies, and was tapped to run the inference infrastructure behind Eli Lilly's TuneLab 2.0.
Tamarind Bio
Tamarind Bio is a San Francisco software company building cloud infrastructure that lets bench scientists run 250+ AI and physics-based models for drug discovery - tools like AlphaFold, RFdiffusion, ProteinMPNN and GROMACS - through a no-code web interface and API, without managing GPUs, data pipelines or DevOps. Founded in 2023 by Stanford computer scientist Deniz Kavi and Sherry Liu, the company serves over 10,000 scientists, including 8 of the top 20 pharmaceutical companies, and raised a $13.6M Series A in February 2026.
Marc Lajoie
Marc Lajoie is a protein designer turned biotech CEO. He co-founded Outpace Bio in 2021 in Seattle, where he is chief executive, building engineered cell therapies that aim to bring the kind of cures seen in blood cancers to the solid tumors that make up the vast majority of cancer cases. Trained in George Church's genome-engineering lab at Harvard and David Baker's Institute for Protein Design at the University of Washington, Lajoie helped pioneer the design of proteins with moving parts - molecules that compute, switch, and make decisions inside living cells. Outpace raised a $144M oversubscribed Series B in 2024 to push its AI-powered, protein-designed therapies toward the clinic.
Profluent
Profluent is an AI-first protein design company building frontier models that author novel proteins - including the first AI-designed CRISPR gene editor, OpenCRISPR-1. Based in Berkeley's biotech corridor, the company applies the same scaling-law playbook that worked for language models to the language of biology, then validates the outputs in a wet lab.
Ali Madani
Ali Madani is the founder and CEO of Profluent, the AI-first protein design company based in Emeryville, California. A machine learning researcher by training, he holds a PhD from UC Berkeley and pioneered the use of large language models to generate functional proteins from scratch - first at Salesforce AI Research as the architect of ProGen, then at Profluent where his team created OpenCRISPR-1, the world's first AI-designed and open-source gene editor, published in Nature in 2025. With $150M in total funding from Bezos Expeditions, Altimeter Capital, Spark Capital, and Insight Partners, Madani is on a mission to make biology programmable - designing proteins that don't exist in nature to solve the biggest challenges in human health, agriculture, and biomanufacturing.