chronic-disease
(16)
Respiree
Respiree is a Singapore-founded digital health company (an A*STAR spin-off) building clinically validated AI that pairs FDA-cleared cardio-respiratory wearable sensors with software to track lung and heart biomarkers over time. Its 1Bio platform helps hospitals, health systems and biopharma detect patient deterioration - such as COPD flare-ups and heart failure - days in advance, powering remote patient monitoring, clinical decision support and decentralized clinical trials across Asia-Pacific, Australia and the United States.
Virtue Diagnostics
Virtue Diagnostics is a platform-based in vitro diagnostics (IVD) company headquartered in Singapore, with manufacturing in Suzhou, China and clinical operations in Beijing. Founded in 2019, it develops affordable diagnostic instruments and reagents across chemiluminescence, clinical chemistry, hematology, clinical mass spectrometry, multiplex immunohistochemistry (mIHC) and molecular diagnostics, aiming to serve patients through every stage of disease - from early screening and diagnosis to treatment monitoring and minimal residual disease management. Its strategy centers on localized innovation and expansion in emerging markets including China, Singapore, Brazil, Indonesia and the Philippines. The company closed a US$100 million Series B round in January 2022 led by Sequoia China and Morningside Ventures.
Simple HealthKit
Simple HealthKit is a Milpitas, California-based digital health company building end-to-end healthcare infrastructure that unifies at-home and in-clinic diagnostics, a CLIA-certified lab, telehealth, and follow-up care into a single platform. Founded in 2018 by biochemist Sheena Menezes, the company targets health equity by making testing for sexual health, respiratory illness (COVID/flu/RSV), and chronic conditions like diabetes accessible and affordable for underserved populations, selling primarily to health plans, retailers, pharmacies, employers, schools, and public health organizations.
Prado
Prado is an Austin-based Food-as-Medicine platform that lets clinicians prescribe medically tailored meals and lets patients pay for them with pre-tax HSA/FSA dollars. It stitches together the parts that usually don't talk to each other - a compliant Letter of Medical Necessity, HIPAA- and IRS-approved checkout, white-label storefronts, and fulfillment - so healthy prepared food becomes both prescribable and reimbursable. Founded in 2020 by former Snap Kitchen CEO Jon Carter, Prado has supported the sale of more than 25 million meals and connects food operators to a network of 70M+ tax-advantaged account holders.
Samay
Samay (formerly Respira Labs) is a San Francisco Bay Area medtech company building Sylvee, a wearable chest patch that pings the lungs with sound waves and uses AI to detect COPD and predict flare-ups before they turn dangerous. Founded by physician-inventor Dr. Maria Artunduaga, the company turns a $40 acoustic sensor into a continuous, at-home alternative to hospital pulmonary function tests, aiming to catch the invisible early signs of lung disease that standard tools miss.
Matthew Loper
Matthew Loper is the co-founder and CEO of Wellth, a Los Angeles digital-health company that pays people small cash rewards for sticking to their care plans. A biological engineer from MIT turned healthcare banker and investor, he built Wellth around behavioral economics rather than technology - the idea that immediate, tangible incentives change what people actually do about their chronic conditions. Under his leadership Wellth has raised more than $73 million, including an oversubscribed $36 million Series C in 2025, and reports steep drops in hospital and emergency-room use among the high-need Medicare and Medicaid populations it serves.
Adhera Health
Adhera Health builds an empathic AI 'precision digital companion' for families managing pediatric chronic conditions - growth hormone therapy, type 1 diabetes, childhood obesity, autoimmune and oncology cases. The platform pairs behavioral science with personalization technology to support caregivers, improve treatment adherence, and surface what happens between clinical visits.
Empo Health
Empo Health makes diabetic foot ulcer detection as easy as stepping on a bathroom scale. The Empo Footprint imaging scale captures high-resolution images of patients' feet at home and sends them to clinicians through the HIPAA-compliant Empo Remote Health Link, catching ulcers before they become amputations.
Kivo Health
Kivo Health delivers virtual pulmonary rehabilitation for people living with COPD. Patients receive a Kivo Kit - a cellular-connected iPad, Bluetooth pulse oximeter, and exercise bands - then join live small-group video sessions with licensed respiratory therapists twice a week from their living rooms. The Y Combinator-backed, San Francisco company partners with health systems like UCLA Health, UCSF Health, Cedars-Sinai, and Novant Health to keep Medicare members out of the hospital while improving symptoms, activity, and mood.
Arda Therapeutics
Arda Therapeutics is a San Carlos, California biotech building precision biologics that eliminate the specific cells driving chronic disease rather than tinkering with the proteins those cells produce. Using a single-cell data discovery engine, Arda maps disease-specific cell states, pinpoints their surface markers, and designs targeted therapies that deplete only the harmful cells while sparing healthy tissue. Founded in 2021 by former Calico scientist Adam Freund, the company is applying lessons from oncology to fibrosis, autoimmune, and metabolic disease, backed by a $43M Series A led by a16z Bio + Health.
DeLorean Artificial Intelligence
DeLorean Artificial Intelligence is a Palm Beach, Florida-based healthcare AI company that builds predictive and interventive intelligence to forecast chronic disease and recommend next-best clinical actions before a patient gets sicker. Its flagship Medical AI platform, MARTI, analyzes structured and unstructured health records to predict events like hospitalizations and disease progression - and is described as the first medical AI to be biologically validated by independent third parties. Founded in 2019 by Dr. Severence MacLaughlin, the company also applies its predictive engine to sales/CRM, life sciences, financial services and other industries.
Glen Tullman
Glen Tullman is a serial health-tech entrepreneur and CEO of Transcarent, the consumer-directed health and care platform he founded in 2021. Over three decades he turned Allscripts into the dominant electronic health records provider, founded Livongo Health and sold it to Teladoc for $18.5 billion - the largest consumer digital health deal in history - and co-founded 7wireVentures, one of the top-returning venture funds in Illinois. Now leading Transcarent's $621M acquisition of Accolade and pushing AI-powered 'WayFinding' tools into employee benefits, Tullman is also a Giving Pledge signatory who has committed most of his estimated $1 billion fortune to healthcare and education.
Kurt Knight
Kurt Knight is the CEO of Foodsmart, the largest digital food-as-medicine platform in the United States, appointed in March 2025 after 13 years at Amwell where he rose to COO and helped scale virtual care nationally. With an MBA from Harvard, an MPH from Columbia, and field experience everywhere from UNICEF to the Gates Foundation to the Boston Consulting Group, Knight brings an unusually wide lens to the intersection of food, nutrition, and healthcare delivery.
Twin Health
Twin Health builds a Whole Body Digital Twin - a real-time AI model of each member's metabolism that learns from wearable sensors, labs, and daily behavior to reverse type 2 diabetes, obesity, and other chronic metabolic conditions without long-term reliance on medications.
Margo Georgiadis
Margo Georgiadis is CEO-Partner at Flagship Pioneering and co-founder & CEO of Montai Therapeutics, a biotech company using AI to discover drugs from natural compounds humans have consumed for centuries. A Harvard double-alumna (Phi Beta Kappa undergrad, Baker Scholar MBA), she has reinvented herself across industries - from McKinsey partner to Google Americas President, Mattel CEO, Ancestry.com CEO (overseeing its $5B sale to Blackstone), and now biotech pioneer building a platform that turns ancient botanicals and foods into precision medicines for chronic disease.
Julia Hu
Julia Hu is the co-founder and CEO of Lark Health, an AI-powered virtual care platform managing over 30 million contracted lives. Born in Los Angeles to first-generation Chinese immigrants and raised largely by her father, Hu spent her childhood navigating an undiagnosed chronic condition that would ultimately reshape how she saw healthcare. She dropped out of MIT Sloan mid-MBA to build what is now one of the largest CDC-recognized diabetes prevention program providers in the country, having raised over $257 million and earned recognition from Forbes, Inc., and the UCSF Health Awards Hall of Fame.