Breaking
SERIES A Respiree closes US$11.6M round co-led by We Venture Capital & ClavystBio REGULATORY RS001 cardio-respiratory sensor cleared by US FDA SINGAPORE 1Bio AI-Acute cleared by HSA - first AI alternative to an inpatient Early Warning Score BOARD Patty Riskind named Chair, June 2026 US HQ New base opens at Texas Medical Center, Houston INVESTOR Mayo Clinic joins the cap table SERIES A Respiree closes US$11.6M round co-led by We Venture Capital & ClavystBio REGULATORY RS001 cardio-respiratory sensor cleared by US FDA SINGAPORE 1Bio AI-Acute cleared by HSA - first AI alternative to an inpatient Early Warning Score BOARD Patty Riskind named Chair, June 2026 US HQ New base opens at Texas Medical Center, Houston INVESTOR Mayo Clinic joins the cap table
Company Dossier / Digital Health Singapore · Houston · Est. 2019

Respiree.

The breath is a vital sign. Respiree pairs FDA-cleared cardio-respiratory wearables with AI that reads the lungs and heart in real time - and flags trouble days before it lands a patient in the ER.

Remote Patient Monitoring Digital Biomarkers FDA Cleared A*STAR Spin-off
Respiree company logo

The Respiree wordmark. Founded in 2019 as a spin-off from Singapore's A*STAR research agency, the company now runs a US base inside Houston's Texas Medical Center - the largest medical complex in the world. Singapore → Houston

The Story

Fewer alerts, earlier. A different bet on remote care.

Most remote-monitoring tools have the same failure mode: they bury clinicians in alerts until the alerts stop meaning anything. Respiree, a digital health company founded in Singapore in 2019, took the opposite approach. Its pitch, in the words of founder and CEO Gurpreet Singh, is blunt - "What we need is better use of data, not just more data."

The company builds two things that are usually sold separately: hardware and intelligence. On the hardware side is a small, FDA-cleared chest patch - the RS001 - that measures heart rate, respiration and temperature continuously, paired with a fingertip oximeter for blood-oxygen readings. On the intelligence side is 1Bio, an AI platform that folds those sensor streams together with electronic health record data, mobile questionnaires and third-party devices to track how a patient's cardio-pulmonary health is trending over time.

The payoff Respiree describes is timing. For conditions like COPD and heart failure, the system aims to detect deterioration - the slow slide toward a flare-up or a hospital admission - not hours or minutes in advance, but days. That head start is the entire value proposition: a warning early enough for a clinician to actually do something about it.

Respiree grew out of A*STAR, Singapore's national research agency, and it carries that lineage. Singh holds a PhD in electrical and electronic engineering from Nanyang Technological University and did a post-doctoral stint at MIT in integrated photonics before turning his attention to health sensors. The company reads less like a consumer-wearable startup and more like a medical-device firm that happens to run on machine learning.

2019FoundedSingapore A*STAR spin-off
$11.6MSeries AClosed July 2025
~40TeamApprox. headcount
12CountriesData infrastructure reach*
"What we need is better use of data, not just more data - enabling timely interventions and reducing alarm fatigue."
Dr. Gurpreet Singh, Founder & CEO
The Problem

What Respiree is trying to fix

  • Patient deterioration in chronic disease is often caught too late - at the point of an emergency admission.
  • Alarm fatigue: monitoring systems generate so many alerts that clinicians tune them out.
  • Clinical trials rely on episodic, in-clinic measurements that miss what happens day to day.
  • Vital-sign data is abundant but rarely turned into an actionable, early prediction.
Who Uses It

Customers & users

  • Hospitals & health systems - for remote monitoring, chronic disease management and hospital-at-home. Changi General Hospital is a co-development partner; validation work has run with Massachusetts General.
  • Biopharma & diagnostics - for decentralized clinical trials and digital biomarker validation. Roche Diagnostics has run APAC pilots.
  • Clinical research organizations - using a data infrastructure that reportedly spans around 50 sites across 12 countries.
Products & Services

A sensor as the wedge, the data as the business

Platform · 2024

1Bio Platform

The flagship AI/ML platform. It integrates EHR data, mobile questionnaires, third-party devices and Respiree's own sensors to track disease progression across thousands of pulmonary-cardio biomarkers.

Software-as-Medical-Device · 2025

1Bio AI-Acute

A clinical toolbox cleared by Singapore's HSA - reportedly the first AI-powered alternative to an inpatient Early Warning Score approved in the country.

Hardware · 2023

RS001 Sensor

An FDA-cleared wearable chest patch measuring heart rate, respiration and temperature in real time, paired with a fingertip oximeter for SpO2.

Enterprise · 2022

Respiree Care

A remote-care and RPM solution for hospital-at-home, chronic disease management and rehabilitation, with EHR integration built in.

Research · 2023

Decentralized Trials

A biopharma platform for digital biomarker discovery and real-world data aggregation, enabling remote clinical data acquisition across distributed sites.

Business Model · B2B

How it makes money

A blend of device sales, recurring software and analytics subscriptions, and research collaborations with hospitals and biopharma - a hardware-plus-SaaS model.

What Sets It Apart

Different from the RPM crowd

The remote patient monitoring field is crowded - Biofourmis, Current Health, BioIntelliSense, Biobeat, Huma, Cadence and Philips all compete for hospital attention. Respiree's distinctions are less about a single feature and more about how it is built:

  • Owns the full stack - proprietary sensor plus proprietary AI, rather than software layered on someone else's device.
  • Regulation-first - FDA 510(k), CE mark, TGA approval and Singapore HSA clearance, plus ISO 13485 and ISO 27001 certifications.
  • Cardio-pulmonary focus - purpose-built for lung-and-heart biomarkers rather than a generic vitals dashboard.
  • Prediction over measurement - designed to flag deterioration days ahead, not just display current numbers.

Certifications & clearances

  • US FDA 510(k) clearance - RS001 sensor
  • CE mark (Europe)
  • Australia TGA approval
  • Singapore HSA - 1Bio AI-Acute
  • ISO 13485 medical device QMS
  • ISO 27001:2022 information security
  • HIPAA & FDA cybersecurity compliance
Funding

The money behind the mission

Respiree raised a US$3.4M seed in 2022 and a US$11.6M Series A in July 2025, co-led by We Venture Capital and ClavystBio. The round drew a notable name: the Mayo Foundation for Medical Education and Research - Mayo Clinic - joined as both investor and clinical collaborator. In February 2026, Canadian med-tech fund One Six 8 Ventures joined the Series A syndicate to back the company's North American push.

Seed · 2022
US$3.4M
Series A · 2025
US$11.6M

Series A investors: We Venture Capital, ClavystBio, Adaptive Capital Partners, Mayo Clinic, Greenwillow Capital Management, Seeds Capital, She1K. *Some aggregators place total funding near US$15M; figures are approximate.

Timeline

From lab to hospital ward

2019

Respiree founded in Singapore

Incorporated as an A*STAR spin-off led by Gurpreet Singh, with early approval in Australia.

2021

Changi General Hospital collaboration

Joint development of smart remote vital-sign monitoring, backed by NRF Central Gap Funding.

2022

US$3.4M seed round

Raised seed capital and earned early recognition on regional health-tech startup lists.

2023

US FDA 510(k) clearance

The RS001 cardio-respiratory sensor received US FDA clearance.

2024

US incorporation & JLABS residency

Incorporated in the US and joined JLABS @ San Francisco; won the President's Technology Award.

2025

US$11.6M Series A

Closed a Series A co-led by We Venture Capital and ClavystBio; set up US HQ in Houston.

2026

Syndicate expansion & new board chair

One Six 8 Ventures joined the syndicate; Patty Riskind, who scaled Qualtrics' healthcare arm, became Board Chair.

Where It Fits

A med-tech at the seam of three markets

Respiree sits where remote patient monitoring, digital biomarkers and decentralized clinical trials overlap - a seam that has attracted plenty of well-funded competitors but few players who own both the sensor and the algorithms on top of it.

Its center of gravity is shifting west. Founded and validated in Singapore's hospital system, the company incorporated in the US in 2024, joined a JLABS residency, and set up a US headquarters inside Houston's Texas Medical Center. The 2026 additions - a North America-focused fund and a US healthcare board chair - point clearly at the American market, where reimbursement for remote monitoring is more established.

The expertise it leans on is unusual for a startup: photonics and sensor engineering from its founder's research background, layered with the clinical validation and regulatory work that a medical device demands. That combination is slow to build and hard to copy - which, in a regulated market, is closer to a moat than a marketing line.

For hospitals, the promise is practical: catch decompensation early, cut avoidable admissions, and give overstretched teams signal instead of noise. For biopharma, it is a way to run trials that capture continuous, real-world data. Whether Respiree can convert clinical credibility into commercial scale is the open question - but it has assembled an uncommonly deep foundation to try.

FAQ

Questions people ask about Respiree

What does Respiree do?
Respiree builds FDA-cleared cardio-respiratory wearable sensors paired with AI software (the 1Bio platform) to monitor patients remotely, detect deterioration such as COPD flare-ups and heart failure days in advance, and support decentralized clinical trials.
Who founded Respiree and where is it based?
It was founded in 2019 by Gurpreet Singh, an A*STAR research scientist, in Singapore. The company later established a US headquarters at the Texas Medical Center Innovation hub in Houston.
How much funding has Respiree raised?
Respiree raised a US$3.4M seed round in 2022 and a US$11.6M Series A in 2025 co-led by We Venture Capital and ClavystBio, with Mayo Clinic among the investors. In 2026 One Six 8 Ventures joined the Series A syndicate.
Is Respiree's technology cleared by regulators?
Yes. Its RS001 sensor received US FDA 510(k) clearance, and the company holds CE marking, Australia TGA approval, and Singapore HSA clearance for its 1Bio AI-Acute software, along with ISO 13485 and ISO 27001 certifications.
Who uses Respiree's products?
Hospitals and health systems, biopharma and diagnostics companies, and clinical research organizations use Respiree for remote patient monitoring, chronic disease management and decentralized clinical trials across Asia-Pacific, Australia and the US.
Share & Connect

Spread the word

Video & demos: Respiree does not maintain a dedicated public YouTube channel; product and innovation clips are shared primarily via the company and CEO LinkedIn pages linked above.