minimally-invasive
(19)
Selera Medical
Selera Medical is a Y Combinator-backed (W24) medical device startup building MILO - minimally invasive lymphatic offloading - a one-time, catheter-based procedure that treats fluid overload in chronic heart failure. Instead of a lifelong drug regimen, Selera taps the body's lymphatic system to drain trapped fluid from the interstitial space, aiming to break the cycle of repeat hospitalizations that defines late-stage heart failure. Founded in 2023 by CEO Stacie Arechavala and CTO Kevin Bui, both former Stanford Biodesign fellows.
Shreya Mehta
Shreya Mehta is the President and CEO of Zenflow, a South San Francisco medical device company she co-founded in 2014 out of the Stanford Biodesign Innovation Fellowship. A biomedical engineer and former FDA reviewer, she spent a decade building the Zenflow Spring System, a minimally invasive, reversible implant that props open the urethra to relieve symptoms of benign prostatic hyperplasia (BPH). She started as CTO before stepping into the CEO seat, closed a $24M Series C in November 2024, and helped guide the company to FDA approval.
Axon Therapies, Inc.
Axon Therapies is a clinical-stage medical device company developing SAVM (Splanchnic Ablation for Volume Management), a minimally invasive, implant-free catheter procedure that ablates the greater splanchnic nerve to calm an overactive sympathetic nervous system and rebalance blood volume in patients with heart failure - particularly heart failure with preserved ejection fraction (HFpEF). Incubated by the medtech studio Coridea and backed by leading healthcare investors, the company is advancing its Satera Ablation System through randomized, sham-controlled feasibility trials.
Companion Spine
Companion Spine is a medical device company building a full continuum of interventional and surgical therapies for back pain caused by degenerative disc disease and lumbar spinal stenosis. Founded in 2020 by the Viscogliosi Brothers, it focuses on posterior dynamic stabilization and motion-preserving implants - such as DIAM, coflex, CoFix, LISA and APERIUS - that treat spine conditions without spinal fusion. With headquarters in New York and Mérignac (Bordeaux), France, the company aims to offer surgeons a single, indication-specific portfolio spanning diagnosis, pain management and outpatient surgery.
Conformal Medical
Conformal Medical is a Nashua, New Hampshire medical device company developing the CLAAS AcuFORM System, a next-generation left atrial appendage occlusion (LAAO) implant that uses a proprietary foam matrix to seal the left atrial appendage and reduce stroke risk in patients with non-valvular atrial fibrillation. Its design conforms to a wide range of anatomies with only two device sizes, and is intended to make LAAO a same-day, single-operator procedure that can avoid general anesthesia and transesophageal echocardiography. In February 2026 the company became a wholly owned subsidiary of W. L. Gore & Associates.
CSA Medical, Inc.
CSA Medical is a Lexington, Massachusetts medical device company that develops spray cryotherapy technology for the lungs. Its flagship RejuvenAir System delivers a metered dose of -196°C liquid nitrogen through a bronchoscope to destroy the damaged, mucus-producing cells that drive chronic bronchitis in COPD patients, while preserving the underlying tissue matrix so healthy airway cells can regrow. Backed by roughly $161M in total funding including a $53M Series D in 2024, the company submitted its FDA PMA in January 2026 following a successful pivotal SPRAY-CB trial.
Interscope, Inc.
Interscope, Inc. is a Northbridge, Massachusetts medical device company that develops the EndoRotor, a flexible, powered endoscopic resection system that dissects, resects, and collects tissue in the gastrointestinal tract without thermal energy. Founded in 2011, the company created the first flexible microdebrider designed for the digestive tract and holds the first and only FDA marketing authorization for Direct Endoscopic Necrosectomy (DEN) in walled-off pancreatic necrosis. Interscope sells to interventional gastroenterologists and hospitals, and distributes the EndoRotor system through a partnership with Micro-Tech Endoscopy.
Preceptis Medical
Preceptis Medical is a Golden Valley, Minnesota medtech company that makes the Hummingbird Tympanostomy Tube System (TTS), an FDA-cleared handheld device that lets ENT surgeons place pediatric ear tubes in the office in about five minutes using only a topical anesthetic - no operating room and no general anesthesia. By combining the multiple tools of a traditional tube procedure into a single-pass instrument, Preceptis aims to make a very common childhood surgery safer, faster, and dramatically less expensive for families and payers.
Jeffery Ryan
Jeffery Ryan is the co-founder, president, and CEO of Interscope, Inc., a Massachusetts medical device company behind the EndoRotor System, a mechanical, non-thermal tool for interventional gastroenterology and pulmonology. A former U.S. Air Force captain who moved into medical device sales at Medtronic and Smith & Nephew, Ryan launched Interscope in 2013 with physician co-founder Dr. Ramon A. Franco, Jr., steering the EndoRotor from concept to FDA clearances and a 2020 distribution partnership with Micro-Tech Endoscopy.
InterVene, Inc.
InterVene, Inc. is a Redwood City, California vascular medical device company building catheter-based tools for severe venous disease. Born out of Stanford Biodesign, it first pioneered BlueLeaf, a non-implantable system that forms new vein valves from a patient's own tissue, then pivoted its lead product to Recana, an FDA-cleared thrombectomy catheter system that clears venous in-stent restenosis and native-vessel obstructions - a stubborn problem that leaves stented patients with debilitating complications and few good options.
Neptune Medical
Neptune Medical is a Silicon Valley medical device company building the future of gastrointestinal endoscopy around its proprietary Dynamic Rigidization technology, which lets a thin-walled tube toggle instantly between flexible and rigid states using vacuum. Its first FDA-cleared product, the Pathfinder overtube, tackles the old and unglamorous problem of endoscope 'looping' during colonoscopy, and has been used in more than 15,000 patients. The company is now extending that platform into the Triton robotic endoscopy system, which posted a clean 100% cecal intubation rate with no adverse events in its first-in-human study.
Revamp Medical
Revamp Medical is an Israeli medical device company building the Doraya catheter, a temporary, adjustable flow-reducing catheter for patients hospitalized with acute heart failure. Deployed in the infrarenal inferior vena cava for up to 12 hours, Doraya is designed to relieve venous congestion and improve response to diuretic therapy in patients who respond poorly to standard drugs - addressing the local mechanism of diuretic resistance rather than relying on systemic drugs or dialysis. Founded in 2016 and based in Netanya, the company won FDA Breakthrough Device designation in 2020 and closed a KCK Medtech-led Series A in 2023 to fund U.S. clinical trials.
Zenflow, Inc.
Zenflow is a South San Francisco medical device company that built the Spring, a small nitinol coil implanted through a flexible cystoscope to prop open the urethra and relieve the symptoms of an enlarged prostate (benign prostatic hyperplasia). Spun out of Stanford's Biodesign program in 2014, the company won FDA approval in December 2025 for a first-line interventional therapy that requires no catheter afterward, preserves sexual function, and can be reversed. It has raised roughly $85 million across multiple rounds and ran the multinational BREEZE pivotal trial to get there.
NeuroBionics
NeuroBionics is a Boston-area neurotechnology company spun out of more than a decade of MIT research. It builds hair-thin, flexible bioelectronic fibers that reach neural targets through the body's blood vessels instead of open surgery. Its lead device, evStim, aims to deliver deep brain and peripheral nerve stimulation endovascularly, potentially widening access to neuromodulation therapy for conditions like Parkinson's disease, epilepsy, chronic pain, and depression.
MJ Antonini
MJ Antonini is the co-founder and CEO of NeuroBionics, an MIT spinout building hair-thin, flexible bioelectronic fibers that thread through blood vessels to reach deep neural structures - delivering deep brain stimulation without opening the skull. A Harvard-MIT Health Sciences and Technology graduate who trained in both medicine and engineering, he turned a decade of fiber research from Polina Anikeeva's MIT lab into a venture-backed company that raised an oversubscribed $10M seed round to push toward first-in-human trials.
CoapTech
CoapTech is a Baltimore-based medical technology company that built the world's first ultrasound-guided gastrostomy system. Its FDA-cleared PUMA-G System lets bedside clinicians place feeding tubes using only ultrasound imaging and a patented magnet-aligned catheter, replacing procedures that traditionally required an operating room, endoscopy, or interventional radiology. The approach aims to make feeding-tube placement faster, safer, and cheaper, and has been used in more than 1,000 patients across ICUs, step-down units, and long-term acute care hospitals.
Darryl Barnes
Darryl Barnes is a physician-turned-inventor who co-founded Sonex Health, an Eagan, Minnesota medtech company building ultrasound-guided devices that move carpal tunnel and trigger finger surgery out of the operating room and into the clinic office. A former Mayo Clinic sports medicine doctor, he co-invented the UltraGuideCTR device, holds numerous medical device patents, and helped raise more than $60 million to scale the company. He has served as both CEO and chief technology officer, and was named Medical Devices CEO of the Year for the Upper Midwest in 2018.
Sonex Health
Sonex Health is a Minnesota-based medical device company that pioneered minimally invasive, ultrasound-guided treatments for common hand conditions. Its flagship UltraGuideCTR (carpal tunnel) and UltraGuideTFR (trigger finger) devices let surgeons see critical anatomy in real time and perform releases through a tiny incision in an office setting, allowing patients to return to normal activity in days rather than weeks. Founded in 2014 by Mayo Clinic physicians, the company has treated more than 20,000 carpal tunnel patients and raised over $62 million to make ultrasound-guided release the standard of care.
Prithipal Sethi
Dr. Prithipal S. Sethi is a board-certified urologist, founder and CEO of Golden State Urology, and Chief Medical Officer at Promaxo - the company pioneering in-office MRI technology for prostate cancer diagnosis and treatment. With over 25 years of clinical practice, 2,500+ enlarged prostate procedures performed, and a career rooted in bringing advanced imaging technology directly into the urologist's office, Sethi straddles the worlds of clinical medicine and medical device innovation. Trained at UC Berkeley, St. Louis University, and Medical College of Wisconsin, he built Golden State Urology from a single Stockton practice in 2004 into a multi-location Northern California institution, and now serves as a clinical voice for a technology that is reshaping how prostate cancer is caught and treated.