gastroenterology
(4)
Neptune Medical
Neptune Medical is a Silicon Valley medical device company building the future of gastrointestinal endoscopy around its proprietary Dynamic Rigidization technology, which lets a thin-walled tube toggle instantly between flexible and rigid states using vacuum. Its first FDA-cleared product, the Pathfinder overtube, tackles the old and unglamorous problem of endoscope 'looping' during colonoscopy, and has been used in more than 15,000 patients. The company is now extending that platform into the Triton robotic endoscopy system, which posted a clean 100% cecal intubation rate with no adverse events in its first-in-human study.
Phathom Pharmaceuticals
Phathom Pharmaceuticals is a commercial-stage biopharmaceutical company built around vonoprazan, a first-in-class potassium-competitive acid blocker (P-CAB) it licensed from Takeda in 2019 for the U.S., Europe and Canada. Its lead product, VOQUEZNA, won FDA approval in late 2023 - the first major innovation in U.S. GERD treatment in over 30 years - and is sold for non-erosive and erosive GERD plus H. pylori infection via its DUAL PAK and TRIPLE PAK regimens. The company reached $175.1 million in net revenue in 2025 and expects operating profitability in 2026.
G-Tech Medical
G-Tech Medical builds the GutTracker, a thin wireless wearable patch its team calls an 'EKG for the Gut.' Worn on the abdomen for up to six days at home, the patch reads the faint electrical signals that drive the stomach, small intestine, and colon, then streams them over Bluetooth to the cloud, where algorithms turn the noise into patient-specific motility data. The Mountain View company aims to replace short, single-organ, in-clinic tests with continuous, whole-gut measurement so physicians can finally see how a digestive system actually behaves day to day.
Oshi Health
Oshi Health is a virtual-first gastrointestinal care clinic that gives the roughly one in four Americans living with digestive disorders fast access to a coordinated team of GI providers, registered dietitians, behavioral health specialists, and care coordinators. Available in all 50 states as an in-network benefit, Oshi pairs unlimited virtual visits and messaging with evidence-based, whole-person treatment - an approach a national health plan's analysis tied to 92% symptom improvement, 98% patient satisfaction, and more than $10,000 in medical cost savings per patient over six months.