anti-aging
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How Two Golf Buddies Sold America Clear Skin at 2 A.M.
Guthy-Renker turned late-night television into a direct-to-consumer machine - Proactiv, Meaningful Beauty, JLo Beauty - by pairing a famous face with a subscription box decades before subscriptions were cool.
PranaX
PranaX is a Houston-based regenerative medicine biotechnology company developing stem cell-derived exosome products to counter aging, inflammation, and tissue damage. Built on exosome technology exclusively licensed from The University of Texas MD Anderson Cancer Center, PranaX operates an FDA-registered cGMP facility at the Levit Green life science campus and is bringing to market a physician-directed exosome wellness supplement (ExoWELL) and a personal exosome banking service (ExoSTORE). The company closed an oversubscribed $17M Series A in early 2026.
OneSkin
OneSkin is a San Francisco biotech and direct-to-consumer skincare company founded by four Brazilian women scientists who set out to slow skin aging at the molecular level. Its flagship OS-01 peptide - identified from a library of 900+ candidates using computational screening and tested on lab-grown human skin models - targets senescent 'zombie' cells that drive wrinkles, thinning and loss of firmness. The company sells topical 'supplements' for the face, eyes, body and sun protection, and frames skin not as a cosmetic surface but as the body's largest organ and a lever on overall healthspan.
ACTIVZ
ACTIVZ is a West Jordan, Utah-based health and wellness company that bills itself as the first direct-selling brand built around epigenetics - the idea that lifestyle and nutrition can influence how genes express themselves. Founded in 2017 by David Brown and Ryan Thompson, the company sells supplements (LINQ, AIRO, Optimend) and an anti-aging skincare line through a distributor network paired with an omnichannel e-commerce model. It launched first in Spanish-speaking Mexico before expanding to the US, Peru, Japan and beyond.
Dermalogica
Dermalogica is a Los Angeles-born professional skin care company founded in 1986 by skin therapist Jane Wurwand and her husband Raymond. Built out of the International Dermal Institute - a training school Wurwand launched three years earlier - the brand pairs clinically minded, irritant-free formulations with rigorous therapist education, selling only where a licensed skin professional can advise. Now a Unilever Prestige brand sold in more than 80 countries, Dermalogica is widely regarded as the world's number one professional skin care line, known for franchises like BioLumin-C, Age Smart, Active Clearing and the teen-focused Clear Start.
Generation Lab
Generation Lab is a San Francisco longevity biotech building SystemAge, a diagnostic that measures how fast your body is actually aging rather than predicting a number. Using DNA methylation analysis of hundreds of biomarkers, it reports biological ages across roughly 19 organ systems from a blood sample, then hands clinicians an actionable plan to track whether interventions are moving the needle. Founded in 2023 by CEO Alina Rui Su, UC Berkeley aging researcher Dr. Irina Conboy, and operator Michael Suswal, the company raised an $11M seed in October 2025 led by Accel and works with 275+ clinics across roughly 18 countries.
Mitrix Bio
Mitrix Bio is a Bay Area biotech startup building bioreactor-grown mitochondria - the cell's power plants - packaged into vesicles it calls 'Mitlets' and delivered by injection. Founded by former SLAC accelerator manager Tom Benson, the company treats the slow decline of mitochondria as a root cause of aging and aims to manufacture autologous, young mitochondria at industrial scale so clinicians can regenerate organs, boost immunity and cognition, and extend healthy human lifespan toward 130 years.
OXOMIO
OXOMIO is a luxury wellness company that makes fermented supplements and nutricosmetics for gut, skin, hair and general health. Founded in 2017 by David Friedeberg, it uses a proprietary bio-fermentation process (GPM - Glycoprotein Matrix) to produce highly bioavailable organic vitamins and minerals, and combines them with branded ingredients such as Peptan marine collagen, LactoSpore probiotics and Superba Boost krill oil. It sells direct-to-consumer online under the tagline 'The Luxury of Wellness.'
Alina Su
Alina Su is the co-founder and CEO of Generation Lab, a San Francisco longevity startup building an at-home cheek-swab test that measures biological age across organs and systems. She got her first medical device patent at 15, founded the needle-free injection company NovaXS, left a Harvard Medical School PhD to commercialize aging science from UC Berkeley's Conboy Lab, and made Forbes 30 Under 30 in 2023. Generation Lab has raised about $11M and counts geneticist George Church and Aubrey de Grey among its advisors.
Max Kholin
Maxim (Max) Kholin is the co-founder and COO of Gero, a physics-powered longevity biotech company applying statistical physics and AI to crack the biology of aging. With roots in contract law, international business, and computational drug design, he bridges the gap between cutting-edge science and real-world commercialization. Gero - which he co-founded with physicist Peter Fedichev in 2015 - has pioneered the field of 'Gerophysics,' trained its models on 100M+ longitudinal medical records, and secured partnerships with Pfizer and Chugai Pharmaceutical worth up to $250M in milestones. Based across Singapore and Palo Alto, Kholin's mission is nothing less than transforming humans into a non-aging species.
Bryan Johnson
Bryan Johnson is an American tech entrepreneur who built and sold Braintree (the parent of Venmo) to PayPal for $800 million, then funneled the proceeds into venture firm OS Fund and neurotech startup Kernel. He is now best known for Blueprint, a personal protocol and commercial brand built around his 'Don't Die' philosophy, chronicled in the 2025 Netflix documentary 'Don't Die: The Man Who Wants to Live Forever.'