weight-loss
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The Diet That Invented Group Therapy Now Writes Prescriptions
It taught a generation to count points and lean on each other. Then a weekly shot changed the math - so WeightWatchers went to the doctor.
Fitia
Fitia is an AI-powered nutrition tracking and meal planning app built by two childhood friends from Peru. It turns the daily grind of counting calories into a personalized plan: users log food by photo, voice, text, or barcode, and Fitia adapts meal plans, macros, and grocery lists to their goals and food preferences. Backed by Y Combinator (S21), it has grown to more than 10 million users across 150+ countries and outranks incumbents like MyFitnessPal in downloads across Spain and much of Latin America.
Nori
Nori is an AI health coach that connects a person's scattered health data - Apple Health, Oura, Whoop, Garmin, Peloton, nutrition apps, medical records and lab tests - into one place and turns it into a personalized daily plan. Founded in 2025 by Chartable veterans Dave Zohrob and Harish Agarwal, the New York startup is part of Y Combinator's Fall 2025 (F25) batch and aims to make health optimization feel less like a second full-time job.
Klarity Health
Klarity Health is a U.S. telehealth marketplace that connects patients with thousands of independent, licensed and board-certified providers for affordable online care across mental health, ADHD, weight loss, primary care and more than 200 conditions. Founded in 2020 during the COVID-19 mental health surge, the company pairs a consumer-facing appointment platform with software, marketing and back-office tools that let solo practitioners run profitable virtual practices - an operating model it extended in 2025 with the launch of Kiwi Health, a growth and engagement SaaS built for private providers.
Helicore Biopharma
Helicore Biopharma is a South San Francisco clinical-stage biopharmaceutical company building first-in-class GIP (glucose-dependent insulinotropic polypeptide) antagonists for obesity and cardiometabolic disease. Its lead candidate, HCR-188, is a humanized monoclonal antibody that binds circulating GIP ligand rather than the GIP receptor, a mechanism designed to improve the quality of weight loss - favoring fat loss over lean mass when paired with GLP-1 - and to restore leptin sensitivity. Incubated by Versant Ventures, the company emerged from stealth in January 2025 with a $65 million Series A and is advancing a pipeline of long-acting antibody-peptide conjugates aimed at quarterly dosing.
Virta Health
Virta Health is a digital health company on a mission to reverse type 2 diabetes and obesity in 100 million people. Founded in 2014 by Sami Inkinen, Dr. Stephen Phinney, and Dr. Jeff Volek, Virta pairs a nutrition-first, low-carbohydrate clinical protocol with a Continuous Remote Care platform - a mobile app, dedicated physicians and health coaches, and AI-driven personalization - to lower blood sugar, cut medications, and produce durable weight loss without relying on costly drugs or surgery. Sold to employers and health plans on a value-based, outcomes-guaranteed model, Virta has treated over 100,000 members and surpassed $160M in annualized revenue.
Peter DiLaura
Peter DiLaura is the CEO and Board Director of Helicore Biopharma, a San Mateo biotech building long-acting antibody-peptide conjugates that go after obesity by neutralizing the GIP hormone in the bloodstream rather than blocking its receptor. With nearly three decades of company-building behind him - CEO roles at Initial Therapeutics and Second Genome, business and strategy chief at Sonoma Biotherapeutics, and time as an Entrepreneur-in-Residence at Third Rock Ventures - he is the operator brought in to turn a $65M Series A and a clinic-ready antibody into medicines that aim for quarterly dosing and better-quality weight loss.
Hone Health
Hone Health is a New York-based telemedicine clinic built for preventive and longevity care. It pairs at-home and in-person testing of 40+ biomarkers with physician-guided treatment plans for hormone optimization, menopause, weight loss, sexual health, thyroid and more, delivered nationwide on a subscription model starting around $129/month. After raising a $33M Series A in January 2025 and acquiring in-home care company ivee, Hone has tested 300,000+ patients and treats roughly 55,000 active members.
Sesame
Sesame is a direct-pay, cash-only healthcare marketplace that lets patients shop for doctor visits, labs, imaging, prescriptions and specialty care online without insurance. Often called 'the Expedia for medical care,' it lists transparent prices from thousands of providers across all 50 states, with one-time visits starting around $39 and memberships from $19. Founded in 2018 by David Goldhill, Michael Botta and John Fontein, Sesame aims to strip bureaucracy out of healthcare so patients and clinicians transact directly.
Twin Health
Twin Health builds a Whole Body Digital Twin - a real-time AI model of each member's metabolism that learns from wearable sensors, labs, and daily behavior to reverse type 2 diabetes, obesity, and other chronic metabolic conditions without long-term reliance on medications.
Signos
Signos is a San Francisco Bay Area digital health company pairing a continuous glucose monitor with an AI-driven app to help non-diabetic adults lose weight and improve metabolic health through real-time, personalized feedback on food, sleep, stress and exercise.