san-francisco-biotech
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Tara Nickerson
Tara Nickerson, PhD, is President, CEO and Director of Therini Bio, a clinical-stage biopharmaceutical company developing fibrin-targeting immunotherapies for neurological and retinal diseases. A biopharma executive with more than 20 years of experience, she was a founding-team member and Chief Business Officer at both Maze Therapeutics and Prothena Corporation before taking the top job at Therini in 2024. She combines a research background from McGill University with an MBA from UC Berkeley's Haas School and a long track record of company-building, financing and dealmaking in the life sciences.
Tom Soloway
Tom Soloway is the Chief Executive Officer of T-knife Therapeutics, a transatlantic biotech developing T-cell receptor (TCR-T) therapies aimed at solid tumors. With more than 25 years across strategy, operations, corporate finance and venture capital, he has helped build and finance a string of life sciences companies including Transcept Pharmaceuticals, Ascendis Pharma and Audentes Therapeutics. He took the helm of T-knife in January 2021, positioning the Berlin- and San Francisco-based company to move its 'supercharged' TCR-T candidates into the clinic while staying lean and capital-efficient.
Glycyx
Glycyx is a San Francisco biopharmaceutical company developing axelopran, an orally administered peripheral mu-opioid receptor antagonist, to counter opioid-induced immunodeficiency in cancer patients. Roughly 45% of immunotherapy patients take opioids for pain, and studies link that use to sharply worse outcomes on checkpoint inhibitors. Axelopran blocks opioid signaling on immune cells - without touching pain relief - to restore T-cell infiltration into tumors and make 'cold' tumors respond to immunotherapy. The company is Phase 2b-ready with an active IND and has drawn NIH SBIR grant support.
OneSkin
OneSkin is a San Francisco biotech and direct-to-consumer skincare company founded by four Brazilian women scientists who set out to slow skin aging at the molecular level. Its flagship OS-01 peptide - identified from a library of 900+ candidates using computational screening and tested on lab-grown human skin models - targets senescent 'zombie' cells that drive wrinkles, thinning and loss of firmness. The company sells topical 'supplements' for the face, eyes, body and sun protection, and frames skin not as a cosmetic surface but as the body's largest organ and a lever on overall healthspan.
T-knife Therapeutics
T-knife Therapeutics is a clinical-stage biotech engineering T-cell receptor (TCR-T) therapies to treat solid tumors. Spun out of Berlin's Max Delbrück Center in 2015, it built a proprietary humanized-TCR mouse platform (HuTCR) that grows a full human immune repertoire in mice, letting the company harvest fully human TCRs naturally selected for affinity and specificity. Now dual-based in San Francisco and Berlin, T-knife is advancing 'supercharged' TCR-T candidates - including a PRAME-targeted, CRISPR-armored therapy (TK-6302) entering the clinic - against cancers that have long resisted cell therapy.
NeuroAge Therapeutics
NeuroAge Therapeutics is a San Francisco tech-bio company that measures how old your brain actually is - and tries to make it younger. Founded in 2022 by physician-scientist Dr. Christin Glorioso, the company's flagship NeuroAge Test blends brain MRI, cognitive games, proprietary RNA blood biomarkers, and genetic screening into a single 'brain age' score that aims to flag dementia risk up to 30 years before symptoms appear. The longer-term goal is bolder: small-molecule drugs that reprogram aging neurons back toward a younger state.
Shennon Biotechnologies
Shennon Biotechnologies is a San Francisco biotech turning immune-cell target discovery from a months-long slog into a same-day job. Its proprietary TCELERATOR platform fuses ultra-high-throughput microfluidics with AI to functionally profile millions of single immune cells in hours, pinpointing the rare T and B cells that recognize cancer antigens. Founded in 2021 by physicist-turned-founder Li Sun, the company is building a pipeline of validated targets for solid tumors and autoimmune disease, backed by a $13M seed round led by DCVC.
Li Sun
Li Sun is the founder and CEO of Shennon Biotechnologies, a San Francisco single-cell immunotherapy company that profiles millions of immune cells in hours to pinpoint the rare T cells and antibody targets that fight cancer. A physicist by training (PhD from Harvard's Weitz lab, M.Eng from MIT), she spent five years as a deep-tech venture investor at Bessemer and Foundation Capital before building the platform herself. Shennon emerged from stealth in March 2023 with a $13M seed round led by DCVC.
Loyal
Loyal is a San Francisco clinical-stage veterinary biotech developing the first FDA-track drugs designed to extend the healthy lifespan of dogs. Its lead candidate, LOY-002, is a beef-flavored daily pill for senior dogs that targets metabolic dysfunction in aging. In 2023 it became the first company to receive an FDA acceptance that a drug can be developed to extend lifespan itself - in any species.