cpg-1018
(3)
Dynavax Technologies
Dynavax Technologies is an Emeryville, California biopharmaceutical company built around CpG 1018, a proprietary vaccine adjuvant that sharpens the immune system's response. Its flagship product, HEPLISAV-B, is the first and only two-dose adult hepatitis B vaccine approved in the U.S. and Europe, and had grown to roughly 44% U.S. market share by the end of 2024. Beyond hepatitis B, Dynavax licenses CpG 1018 to other vaccine developers - most visibly as an ingredient in several COVID-19 vaccines - and has advanced its own pipeline in shingles, plague, pandemic influenza, and Lyme disease. In December 2025 Sanofi agreed to acquire Dynavax for about $2.2 billion; the deal closed in February 2026.
Dino Dina
Dr. Dino Dina is a Genoa-born physician-scientist who spent 15 years building Dynavax Technologies as its President and CEO, shepherding the company through the long road toward HEPLISAV-B, a two-dose hepatitis B vaccine whose CpG 1018 adjuvant technology later became a cornerstone of global COVID-19 vaccine programs. Before Dynavax, he built the Vaccine Group at Chiron Corporation and led Chiron Vaccines to the first-ever approval of an adjuvanted influenza vaccine in Italy. Since retiring in 2013, he has poured equal scientific rigor into his Cimarossa estate on Howell Mountain, Napa Valley - 60 mountain acres of vines and 1,200 olive trees named for the Italian phrase meaning 'red hilltop.'
Ryan Spencer
Ryan Spencer is the CEO of Dynavax Technologies, the Emeryville biotech behind HEPLISAV-B and the CpG 1018 adjuvant. He joined as an interim controller in 2005, climbed for fourteen years through finance, IR, and commercial roles, and took the top job in December 2019. Under him, Dynavax supplied adjuvant for nearly a billion COVID-19 vaccine doses and, in December 2025, agreed to be acquired by Sanofi for roughly $2.2 billion.