waltham-massachusetts
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The Company Betting Your Files Should Never Leave Microsoft
Nick Stamos spent two decades stopping data from leaking. His answer to the messiest problem in enterprise IT - sharing files with outsiders - is to make sure the file never actually goes anywhere.
AVAVA, Inc.
AVAVA, Inc. is a Waltham, Massachusetts medical aesthetics company that builds energy-based laser platforms for skin renewal that work across all skin tones. Spun out of Boston-based Blossom Innovations and rooted in research from Massachusetts General Hospital's Wellman Center for Photomedicine, AVAVA's flagship MIRIA Skin Treatment System pairs patented Focal Point Technology with AI-driven skin visualization to deliver precise, high-energy intradermal treatment for conditions like melasma, hyperpigmentation, and acne scars with minimal downtime.
BostonGene
BostonGene is a Waltham, Massachusetts biotechnology company that applies AI-driven multiomics to cancer. Its Tumor Portrait platform integrates DNA and RNA sequencing with immune and tumor-microenvironment analysis into a single test, producing molecular profiles that help oncologists select therapies and help pharmaceutical partners design trials, identify biomarkers, and accelerate drug development. Founded in 2015 and led by CEO Andrew Feinberg, the company reached unicorn status in 2022.
Humatics
Humatics is a Waltham, Massachusetts technology company building microlocation systems - hardware and software that pinpoint the position of people, vehicles, and machines to millimeter and centimeter precision. Combining industrial-grade ultra-wideband radio with inertial sensors, GNSS, and analytics software, its platform serves two markets: industrial automation and robotics through the Milo Microlocation System, and rail and transit through the Humatics Rail Navigation System. Founded in 2015 by MIT professor David Mindell and industry veteran Gary Cohen, the company works with partners including Siemens Mobility and Hitachi Rail on projects such as the New York MTA subway signaling upgrade.
Avilar Therapeutics
Avilar Therapeutics is a Waltham, Massachusetts biopharmaceutical company pioneering the degradation of extracellular and membrane-bound proteins. Its ATAC (ASGPR Targeting Chimera) platform uses bifunctional small molecules that grab a disease-causing protein floating in circulation and shuttle it into the liver's endolysosome to be destroyed, extending the reach of targeted protein degradation beyond the inside of the cell. Launched in 2021 with backing from RA Capital, Avilar is applying the platform to autoimmune disease, preeclampsia, and other conditions driven by proteins that conventional drugs struggle to address.
yet2
yet2 is an open innovation and technology scouting firm that helps large corporations find external technologies, partners, and ideas to accelerate their R&D pipelines. Since 1999 it has run an online technology marketplace and a hands-on consulting practice that scouts, vets, negotiates, and closes technology deals across industries from chemicals and consumer health to aerospace and electronics. With offices in North America, Europe, and Asia, yet2 connects its corporate clients to a global network of innovators and a database of millions of technologies and unmet needs.
Adden Energy
Adden Energy is a Harvard spinout building dynamically-stable, self-healing solid-state lithium-metal batteries designed to make electric vehicles charge in minutes, last a million miles, and never catch fire. Headquartered in Waltham, Massachusetts, the company is scaling its lab breakthrough into commercial pouch cells on a roll-to-roll pilot line and shipping samples to automakers for validation.