translational-medicine
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Tom Large
Tom Large is the CEO and co-founder of Blue Oak Pharmaceuticals, a Waltham, Massachusetts startup hunting for the next generation of medicines for brain disorders. A neurobiologist by training, he spent two decades inside big pharma - leading neuroscience research at Eli Lilly and running preclinical research and translational medicine at Sunovion - before launching Blue Oak in 2016 to chase drugs with genuinely new mechanisms for bipolar depression, schizophrenia and treatment-resistant depression. His teams pioneered a target-agnostic approach to CNS drug discovery, and he later partnered with AI specialist Exscientia to design 'bispecific' small molecules that hit two targets at once.
Srini Akkaraju
Srini Akkaraju, MD/PhD, is the Founder and Managing General Partner of Samsara BioCapital, a Palo Alto-based venture capital firm he founded in 2016 to translate cutting-edge biology into transformative therapeutics. With a Stanford MD/PhD in Immunology and a computer science foundation from Rice University, Akkaraju has spent over 25 years at the intersection of science and capital - from corporate development at Genentech to partnership roles at J.P. Morgan Partners, Panorama Capital, New Leaf Venture Partners, and Sofinnova Ventures. Samsara has built a portfolio of 93+ companies with 32 IPO exits, backing breakthroughs in immunotherapy, cell therapy, kidney disease, and gene therapy. His conviction-driven approach is evident in moves like a $19M personal stake in Scholar Rock, and his belief that biotech is entering an 'unbelievable innovation cycle' over the next two to three decades.