A West Point officer watched treatment units get built where the virus had already left. He sketched the fix on a napkin. Six years later it is worth $2.15 billion.
CORXEL Pharmaceuticals is a clinical-stage biopharmaceutical company developing innovative therapies for cardiometabolic diseases worldwide. Spun out of RTW Investments in 2019 (formerly JiXing Pharmaceuticals) and dual-based in Berkeley Heights, New Jersey and Shanghai, CORXEL is advancing a pipeline led by CX11, a differentiated oral small-molecule GLP-1 receptor agonist for obesity and type 2 diabetes, alongside JX10 for acute ischemic stroke and JX09 for hypertension. In January 2026 the company raised up to $287 million in Series D1 financing to push these programs through late-stage clinical trials.
Farther is a New York-based technology-driven wealth management firm that pairs human financial advisors with a proprietary 'Intelligent Wealth Platform.' Founded in 2019 by Taylor Matthews and Brad Genser, the company gives advisors an all-in-one digital ecosystem for financial planning, investing, tax optimization, and estate planning, while offering clients a family-office-style experience. After a $150 million Series D led by General Atlantic in 2026, Farther has grown to roughly $23 billion in recruited assets and ranks among the fastest-growing financial services firms in the United States.
Snappy is a New York-based corporate gifting platform that flips the traditional gift on its head: instead of shipping one preselected item, a sender picks a budget and a curated collection, and the recipient chooses the gift they actually want. Founded in 2015 by Hani Goldstein and Dvir Cohen, Snappy started in personal gifting before pivoting to enterprise, and now powers employee recognition, customer loyalty, and sales incentives for thousands of companies. Its recipient-choice model, digital 'unwrapping' experience, thank-you loop, and deep HRIS integrations have made it a favorite of HR and people teams, with more than 6 million gifts delivered across 170+ countries.
Wandercraft is a French robotics company that builds self-balancing walking exoskeletons and, more recently, industrial humanoid robots. Founded in Paris in 2012 by engineers - some with personal ties to degenerative mobility disease - it created Atalante X, a hands-free clinical exoskeleton now used in more than 100 rehabilitation centers, and Eve, the first self-balancing personal exoskeleton designed for home use without crutches. In 2025 the company extended its gait-control expertise into Calvin, a family of industrial humanoids developed with Renault Group and NVIDIA. Wandercraft's stated aim is to blend frontier AI with high-performance hardware to help people work and walk.
Fore Biotherapeutics is a Philadelphia-based, registration-stage precision oncology company developing targeted therapies for patients with hard-to-treat cancers. Its lead candidate, plixorafenib, is a next-generation BRAF inhibitor (a 'dimer breaker') aimed at BRAF-altered solid tumors, including BRAF V600E-mutated high-grade glioma, for which it received FDA Breakthrough Therapy Designation in 2026. Spun out of the Israeli functional-genomics company NovellusDx, Fore has raised more than $200M to push plixorafenib toward an accelerated FDA approval pathway.
Formation Bio is a New York-based, AI-native pharmaceutical company that acquires and in-licenses clinical-stage drug candidates and runs them through a proprietary, technology-driven development platform to bring treatments to patients faster and at lower cost. Formerly known as TrialSpark, the company rebranded in December 2023 and raised a $372M Series D in June 2024 led by Andreessen Horowitz and Sanofi. It pairs in-house drug selection expertise with AI tools for trial design, recruitment, regulatory writing, and safety monitoring, and partnered with OpenAI and Sanofi to build purpose-built AI agents for drug development.
Suno is a Cambridge, Massachusetts company building generative-AI tools that turn a text prompt into a full song - vocals, instruments, and lyrics - in seconds. Founded by four former Kensho machine-learning engineers who were also musicians, Suno has grown into one of the most-used consumer AI apps, with tens of millions of users generating millions of tracks a day. It rode a string of rapid model releases (v3 through v5) and an in-browser DAW called Suno Studio to roughly $300M in annual recurring revenue and a $5.4B valuation, all while fighting - and beginning to settle - copyright lawsuits from the major record labels.
Foodsmart (formerly Zipongo) is a San Francisco-based telenutrition company that pairs registered dietitians with a food benefits marketplace to treat diet-related chronic disease and food insecurity. It serves more than 2.2 million members across employer plans, Medicaid managed care, Medicare Advantage and commercial insurers, and in 2024 raised $200M led by TPG's The Rise Fund to expand its 'Foodscripts' food-as-medicine programs with major U.S. health systems.
Hint Inc. makes unsweetened, fruit-infused water with zero sugar, zero sweeteners, and zero calories. Founded in San Francisco in 2005 by Kara Goldin, Hint grew from a personal health experiment into the #1 unsweetened flavored still water brand in the U.S. The company sells over 25 flavors through major retailers like Whole Foods, Target, Walmart, and Costco, as well as directly through its website — where DTC now represents more than 50% of revenue. With $91M+ raised and an annual revenue of approximately $143M, Hint has quietly built one of the most compelling better-for-you beverage brands in America.
Imply is a San Francisco-based data analytics company that built its platform on Apache Druid - the open-source real-time analytics database that its co-founders helped create. The company offers Imply Polaris, a fully managed cloud database-as-a-service for real-time analytics, and Imply Lumi, billed as the industry's first Observability Warehouse. With $215M in total funding and unicorn status at a $1.1B valuation, Imply serves 100+ enterprise customers including Atlassian, Reddit, and Cisco ThousandEyes, enabling sub-second query performance across terabytes to petabytes of streaming and historical data.
Instabase is an enterprise agentic automation platform that transforms complex, unstructured document workflows into reliable, verifiable AI-driven outcomes. Founded in 2015 by MIT PhD student Anant Bhardwaj, the company's AI Hub platform enables organizations across financial services, insurance, healthcare, and government to automate document-heavy processes — from loan origination to KYC compliance — using packet-aware AI agents with deep document understanding and full auditability. With $322M in total funding, a $1.24B valuation, and customers like NatWest, Rocket Mortgage, AXA, and MetLife, Instabase has positioned itself as the backbone infrastructure for enterprise document intelligence.
Instawork is an AI-powered on-demand staffing platform that connects businesses with vetted hourly workers across hospitality, warehousing, food service, retail, and light industrial sectors. Operating in 400+ cities across the U.S. and Canada, the company uses over 2 billion data signals to match businesses with pre-vetted workers, achieving a 98% worker show rate and filling 90% of jobs within 24 hours — metrics that traditional staffing agencies rarely approach. Founded in 2015 and backed by Y Combinator, Benchmark, Greylock, and TCV, Instawork has raised $171M and serves 15,000+ businesses, with a network of 10M+ workers. The platform handles everything from a single catering shift to large-scale distribution center operations.
Juniper Square is a San Francisco-based fintech company that provides an end-to-end fund operations platform for private markets managers - combining software, data, and fund administration services for general partners in private equity, venture capital, real estate, and credit. Founded in 2014, the company serves over 2,100 GPs managing more than 40,000 funds and $1 trillion in LP capital. In June 2025, Juniper Square raised a $130M Series D at a $1.1 billion valuation, reaching unicorn status, with major investors including Ribbit Capital, Fifth Wall, and Redpoint Ventures.
Ladder is a Palo Alto-based digital life insurance company that lets people apply for fully-underwritten term life coverage online in minutes, with the ability to ladder coverage up or down as life changes. Founded in 2015, it became the first fully digital life insurance carrier in 2021 after launching its own underwriting entity, Ladder Life Insurance Company.
Nirvana Insurance is a San Francisco-based, AI-native commercial trucking insurer that combines real-time telematics data with proprietary risk models to price, underwrite, and manage fleet insurance policies. Founded in 2021 by ex-Samsara, MIT, and Wharton operators, the company turns the data trucks already generate into safer roads, cheaper premiums, and faster claims.
Vouch is a technology-first business insurance broker built specifically for high-growth startups. Founded in 2018 by Sam Hodges and Travis Hedge, it engineers coverage - D&O, cyber, E&O, general liability and more - for venture-backed companies, with digital quoting, claims advocacy, and a growing carrier network. Backed by Ribbit, Index, Y Combinator, Allegis and others, Vouch insures thousands of startups including Brex, Carta, Ramp, and Middesk.
CatalYm is a German clinical-stage biotech developing visugromab, a GDF-15 neutralizing monoclonal antibody designed to reverse immunotherapy resistance in solid tumors and address cancer cachexia.
Decagon is a San Francisco-based enterprise AI company building conversational agents that handle customer support across chat, email, voice and SMS. Its platform, anchored by Agent Operating Procedures (AOPs), lets companies define complex workflows in natural language and apply them consistently across channels. Customers include Hertz, Chime, Notion, Duolingo, Rippling, Bilt, Oura, Eventbrite and Affirm.

Hive is a San Francisco AI company that sells pre-trained machine learning models as APIs, focused on content moderation, AI-generated content detection, and visual understanding. Founded in 2013 by Kevin Guo and Dmitriy Karpman, Hive powers trust and safety at platforms like Reddit, BeReal, and Chatroulette, and runs deepfake detection contracts with the U.S. Department of Defense and Department of Homeland Security.
OpenSpace is a San Francisco-based construction technology company that turns 360-degree video walks of jobsites into AI-powered, navigable visual records pinned to floor plans. Its software stitches site captures into a Google Street View-style digital twin so general contractors can see every corner of a build, track progress, resolve disputes, and coordinate with BIM - without flying anyone to the site.
Star Therapeutics is a South San Francisco clinical-stage biotech building first-in-class antibody medicines for serious diseases, with a 'pipeline-in-a-product' approach. Its lead asset VGA039, developed through subsidiary Vega Therapeutics, is a once-monthly subcutaneous monoclonal antibody targeting Protein S, now in Phase 3 for von Willebrand disease.
The EVERY Company is a San Francisco Bay Area biotech that uses precision fermentation to brew real egg proteins (ovalbumin, pepsin, and more) without chickens. Its ingredients - OvoPro, EVERY Egg White, and EVERY Protein - power baked goods, beverages, and protein bars sold by food brands ranging from startups to multinationals.