pittsburgh-biotech
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Krish Krishnan Built the Biotech Before the Market Could Blink
An engineer learned finance, a scientist sketched an audacious idea, and a married pair funded the first experiment themselves. Ten years later, Krish Krishnan is still treating the IPO as the beginning, not the arrival.
Larry Brown
Larry Brown, Sc.D., is Executive Vice President of R&D and Chief Scientific Officer at Noveome Biotherapeutics, the Pittsburgh clinical-stage biopharma he joined in 2012. He is leading the translation of ST266, a cell-free secretome of hundreds of proteins harvested from amnion-derived cells, from proof of principle into the clinic. Trained at MIT under Robert Langer and in Judah Folkman's surgical research lab at Children's Hospital Boston, he spent 35-plus years inventing drug-delivery systems at Baxter, Alkermes and biotech startups, accumulating more than 100 publications and a thick stack of patents along the way.
Ngoc Thai
Ngoc L. Thai, MD, PhD is a transplant surgeon turned biotech founder who built one of the world's largest pancreas programs before chasing a hunch from a cup of his uncle's tea. As founder, co-CEO and CMO of Pittsburgh-based Imagine Pharma, he is developing IMG-1, a polypeptide first isolated from a Vietnamese tea plant, into therapies that coax insulin-producing islet cells to multiply and regenerate. The company raised a $32.5M Series A in October 2023 to advance IMG-1 across oral delivery, therapeutics, and regenerative medicine platforms aimed at type 1 diabetes, wound healing, and other underserved conditions.
Kim Jaffe
Kim Jaffe, PhD, is Chief Business Officer at BlueSphere Bio, a Pittsburgh-based clinical-stage biotech building personalized T-cell receptor therapies for cancer using its TCXpress discovery platform. A bench scientist turned dealmaker, she trained in cell and molecular biology at Northwestern and Princeton, ran cell-line development and R&D at clinical-stage oncology companies, and now leads strategy, partnerships, and business development as the company pushes TCR T-cell candidates toward high-risk leukemias.