non-invasive
(6)
The company that turned a $6,000 diabetes gadget into a $249 ring
Piyush Gupta left Abbott, watched his wife struggle with gestational diabetes, and decided the fix wasn't a better sensor - it was a cheaper one. A decade later, Ambrosia Systems sells glucose tech in 100-plus countries and just put the whole thing on your finger.
Otolith Labs
Otolith Labs is a Washington, D.C. medical device company building the first wearable to treat vertigo, motion sickness and virtual-reality sickness. Its patented non-invasive Vestibular Resonance Therapy (nVRT) uses precisely tuned bone-conduction vibrations to interact with the motion sensors of the inner ear, quieting the faulty balance signals that cause dizziness. The head-worn OtoBand has been tested on hundreds of subjects, carries an FDA Breakthrough Device Designation, and is pursuing FDA clearance through the De Novo pathway.
Roga
Roga is a neurotech company building a non-invasive vagus nerve stimulation wearable paired with an AI-guided meditation app to reduce stress and burnout. Founded by two people who each managed clinical anxiety, the discreet behind-the-ear device sends gentle electrical pulses to calm the nervous system, while the companion app personalizes meditation and tracks progress. Based in Los Angeles and Toronto, Roga sells direct to consumers and to employers running workplace wellness programs.
Samphire Neuroscience
Samphire Neuroscience is a London-based neurotechnology company building drug-free, hormone-free wearables for women's health. Its flagship product, Nettle, is a headband that uses transcranial direct current stimulation (tDCS) to gently modulate the brain regions tied to mood and pain, worn 20 minutes a day in the run-up to menstruation. Marketed as the first EU-cleared (CE-certified) neuromodulation device for women's health, Nettle targets PMS, PMDD, menstrual pain and related hormonal conditions. Founded in 2021 by neuroscientist Emilė Radytė and IP lawyer Alex Cook, the company has raised roughly $7.77M across pre-seed, seed and Series A rounds.
Neural Galaxy
Neural Galaxy (also operating as Galaxy Brain Scientific) is a Beijing-based brain science company building a precision, non-invasive neuromodulation platform. Its proprietary personalized Brain Functional Sectors (pBFS) technology maps over 200 functional regions of an individual brain, then guides targeted transcranial magnetic stimulation with millimeter accuracy. Founded in 2019 by Harvard and MIT neuroscientists with serial entrepreneur Coach Wei, the company is running clinical and registration trials across depression, Parkinson's, Alzheimer's, autism and aphasia, and has raised roughly $93M to date.
ZAP Surgical Systems, Inc.
ZAP Surgical Systems is a San Carlos, California medical device company that designed and manufactures the ZAP-X Gyroscopic Radiosurgery platform - a self-shielded, vault-free system for non-invasive treatment of brain tumors and other intracranial conditions. Founded by Stanford neurosurgeon and CyberKnife inventor John R. Adler, ZAP is on a mission to democratize stereotactic radiosurgery by eliminating the need for radioactive isotopes and concrete bunkers.