mechanobiology
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Aneesh Sathe and the usefulness of getting lost
The Qritive co-founder learned to make slow work faster. His games, essays, and experiments ask a different question: what happens when you leave room to wander?
Nuevocor
Nuevocor is a Singapore-founded, clinical-stage biotechnology company developing genetic medicines for cardiomyopathies driven by aberrant mechanobiology - the mechanical stresses that damage heart-muscle cells. Spun out of Singapore's A*STAR research agency in 2021, the company built a proprietary discovery engine called PrOSIA (Protein Organ Specific Interactome Analysis) to map the functional root causes of genetic heart disease. Its lead program, NVC-001, is an AAV-based gene therapy for LMNA-related dilated cardiomyopathy, an aggressive inherited heart condition with no targeted treatment. Nuevocor received FDA IND clearance for NVC-001 in June 2025 and has raised roughly US$80.6 million to date, including a US$45 million Series B in May 2025.
Nicholas Geisse
Nicholas Geisse is the CEO of Curi Bio, a Seattle biotech building human-relevant tissue platforms that make lab-grown muscle and heart cells behave more like the real thing. A Cambridge-trained pharmacologist who learned to wire up tiny instruments in Kevin Kit Parker's cardiac engineering lab at Harvard, he spent years at Asylum Research selling and designing atomic force microscopes before joining Curi Bio as Chief Science Officer in 2017. He led development of the Mantarray 3D engineered-muscle-tissue platform and the company's NIH-backed R&D program, then stepped up to chief executive in 2023. His work has collected an Xconomy 'Big Idea' award, an SBA Tibbetts award, and an Edison Award.