Artisan made its name telling companies to stop hiring humans. Its more interesting lesson came after the slogan: autonomous sales works best when the machine knows exactly when to hand the conversation back.
Vendasta doesn't sell to small businesses. It sells to the roughly 60,000 companies that already do - handing them a rebrandable marketplace, a CRM and, now, a payroll of AI employees to put their own logo on.
Beacon Health is a Y Combinator (W26) startup building AI agents that operate real electronic health record systems the way a human employee would - clicking through Epic, athenahealth, and eClinicalWorks to close care gaps, capture risk adjustment codes, handle prior authorizations, and run preventative screening outreach. Aimed at primary care practices in value-based care arrangements, the product turns recorded EHR workflows into deployable agents so small practices can chase quality measures and shared-savings revenue without hiring more back-office staff. Founded in 2025 by Mark Pothen and Obinna Akahara, the company has gone live with an independent physician association covering roughly 40,000 patients.
Cozmo AI (formerly CozmoX AI) builds multimodal 'AI employees' that answer calls, read documents, and complete regulated business processes end to end for financial services, insurance, and enterprise operations. Founded by Alok Kumar and Nuha Hashem - the team behind the Gen Z neobank Zywa - the Y Combinator W22 company runs from San Francisco and Dubai, and says its agents handle voice conversations in 70+ languages including multiple Arabic dialects.
Spaceflow is a San Francisco startup (Y Combinator S26) that makes enterprises 'agent-native.' Instead of selling companies another dashboard, it turns the systems they already run - ERP, email, spreadsheets - into a 'company brain' that AI employees and any MCP agent can read and operate securely, with a human keeping the final say. It starts with procurement and supply chain, where it has processed roughly $400M in annual supplier spend and reached six-figure ARR while in early stage.
Sully.ai is a Mountain View healthcare technology company that builds a 'superhuman team of AI employees' for hospitals and clinics - autonomous AI agents that handle front-desk reception, triage, ambient clinical scribing, medical coding, prescriptions and clinical decision support. The agents plug into existing EHRs like Epic and Athenahealth, aiming to cut administrative load and clinician burnout while keeping documentation HIPAA-compliant. Founded in 2023 and backed by Y Combinator, the company reached seven-figure ARR within ten months and raised a ~$21.8M Series A in January 2025.
Motion is an AI-native work management platform that started as an automatic calendar and task scheduler and has grown into an 'agentic work suite' for small and mid-sized businesses. It bundles projects, tasks, calendar, docs, notes, SOPs, sheets, reports, search and chat into one system, then layers AI 'Employees' on top that actually execute work - drafting proposals, prepping meetings, updating projects and answering clients. Founded in 2019 and backed by Y Combinator, Motion raised $60M in 2025 at a $550M valuation.
Ema builds a 'Universal AI Employee' for the enterprise - autonomous AI agents that plug into existing systems and run business processes across customer support, sales, HR, finance, and compliance. Founded in 2023 by ex-Coinbase CPO Surojit Chatterjee and ex-Okta engineering VP Souvik Sen, the company is headquartered in San Francisco and has raised $61M to date.