agent-native
(4)
Spaceflow
Spaceflow is a San Francisco startup (Y Combinator S26) that makes enterprises 'agent-native.' Instead of selling companies another dashboard, it turns the systems they already run - ERP, email, spreadsheets - into a 'company brain' that AI employees and any MCP agent can read and operate securely, with a human keeping the final say. It starts with procurement and supply chain, where it has processed roughly $400M in annual supplier spend and reached six-figure ARR while in early stage.
Daytona
Daytona builds programmatic, composable computers for AI agents. Its stateful sandboxes spin up in under 90 milliseconds, run untrusted AI-generated code in full isolation, and can be started, paused, or snapshotted on demand. Founded by Ivan Burazin and Vedran Jukic, the company pivoted from developer-environment management into agent-native infrastructure in 2025 and raised a $24M Series A led by FirstMark Capital in February 2026. Customers include LangChain, Writer, Turing, and SambaNova.
ProjectX
ProjectX is a San Francisco-based, Y Combinator-backed startup building Infinity (InfinityOS) - a cloud-native, distributed operating system where every app runs on its own independent compute and GPU inside a single browser tab. Designed for the multi-agent, GPU-native era, it lets humans and AI agents run Blender, Unreal, Isaac Sim, DaVinci, and VS Code side-by-side in one shared workspace.
Factory
Factory builds agent-native software development for enterprises. Its Droids - specialized AI agents for coding, reliability, product, and knowledge work - take tickets, write code, open PRs, and triage incidents alongside human engineers. Founded in 2023 by Matan Grinberg and Eno Reyes, the San Francisco company raised a $150M Series C in April 2026 at a $1.5B valuation led by Khosla Ventures.