BREAKING MEDPLUM SHIPS HEADLESS EHR ON APACHE 2.0 YC S22 - SAN FRANCISCO HQ FHIR-NATIVE / HIPAA-READY / SOC2 OUT OF THE BOX CO-FOUNDERS PREVIOUSLY BUILT MEDXT (ACQ. BY BOX) 21 ENGINEERS REBUILDING HEALTHCARE'S PLUMBING BREAKING MEDPLUM SHIPS HEADLESS EHR ON APACHE 2.0 YC S22 - SAN FRANCISCO HQ FHIR-NATIVE / HIPAA-READY / SOC2 OUT OF THE BOX CO-FOUNDERS PREVIOUSLY BUILT MEDXT (ACQ. BY BOX) 21 ENGINEERS REBUILDING HEALTHCARE'S PLUMBING
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Issue No. 042 · YesPress · Healthcare Desk

Medplum.

A startup, a TypeScript SDK, and a clinic somewhere in Ohio walk into a Git repo. The clinic leaves with an EHR. Photographed at 37.7749° N, 122.4194° W - San Francisco, where the company keeps its servers warm and its license open.
Open Source YC S22 FHIR Native HIPAA · SOC2 San Francisco
The Scene · 2026

A solo founder spins up an EHR before her coffee gets cold.It used to take eighteen months. Now it takes a weekend.

In a co-working space south of Market, a digital-health founder pulls up a terminal. Three commands. A fork of medplum/medplum on GitHub. Within an hour, she has a working clinical data repository, a FHIR API, HIPAA-shaped audit logs, and a React component library that can render an intake form before lunch. None of this used to be possible. For twenty years, "building a healthcare app" meant licensing fees with six zeros, sales calls with Epic, and a compliance officer with a furrowed brow.

Medplum is what happened when a small team of engineers - the kind who like reading specs more than reading TechCrunch - decided that the bottleneck wasn't medicine. It was the back end. So they wrote a better one, made it open source, and walked away from the licensing money. The platform they shipped looks, from a distance, like Firebase. Up close, it's something stranger and more useful: a fully fledged headless EHR, FHIR-native to the bone, hosted if you want it, self-hosted if you don't.

That founder with the coffee? She is the product. So is the radiology startup outside Boston using Medplum to wire up an interoperability engine. So is the pediatric clinic in Lagos running it on its own AWS account. The thing about open-source infrastructure is that you stop being able to count your customers. You start counting forks.

"Open-source Firebase for Healthcare." - Medplum's own pitch on Hacker News, November 2022
By the Numbers

The receipts.

2021Founded
~21Engineers
S22YC Batch
Apache 2.0License
What's in the box · relative module heft
FHIR API
96
SDK & Bots
82
React UI Kit
74
Questionnaires
68
Scheduling
60
ePrescribe / Labs
55
HIPAA · SOC2
100
The Stack

What is Medplum, actually?An honest answer, in three cards.

The Backbone

A FHIR-Native Clinical Data Repository

Patient data lives in a standards-based store you can query with a modern API. No proprietary schemas. No vendor wedge.

The Toolbelt

TypeScript SDK + React Components

Pre-built UI primitives that render FHIR resources. Skip the boilerplate. Ship the patient portal.

The Glue

Bots, Webhooks, Integrations

Server-side logic without a server. ePrescribe networks, lab interfaces, HL7 feeds - already wired.

Who uses it

Builders, not buyers

Digital-health startups racing to launch. Hospital innovation teams escaping their legacy stack. Life sciences shops doing remote patient monitoring. Anyone who would rather write code than a check to a legacy vendor.

Why it's different

The license matters

Apache 2.0 means no vendor lock-in, ever. Pay Medplum if you want the hosted version and support. Don't pay them if you want to run it on your own AWS account. That second sentence is not normal in healthcare.

The Founders

Three people who have built this before.MedXT (YC W13), Box, One Medical, Palantir. A repeat-founder reunion.

Co-Founder · CEO

Reshma Khilnani

MIT EECS. Co-founded MedXT (YC W13, acquired by Box). Stints at Facebook and Microsoft. Visiting Group Partner at YC. The product brain.

Co-Founder · CTO

Cody Ebberson

Director of Engineering at One Medical. Healthcare Engineering Lead at Box. Harvard MBA. The person who actually likes reading the HL7 spec.

Co-Founder · COO

Rahul Agarwal

Machine learning at Palantir. Customer Impact Lead at Applied Intuition. The operator who turns code into contracts.

Use Cases

What can you actually build on this?A short, real list. No fluff.

Custom EHR

The thing you couldn't afford to build

A clinical workflow that fits your specialty - DME, pediatrics, behavioral health - without paying a legacy vendor for features you'll never use.

Patient Portal

Modern frontend, compliant backend

Questionnaires, scheduling, secure messaging, care plans - rendered through React components on top of FHIR.

Interoperability Engine

HL7 ↔ FHIR translation, automated

Bots ingest legacy feeds, normalize them, and push them into the data repository. Radiology, labs, networks - all plugged in.

AI & Analytics

A queryable substrate for models

Structured FHIR resources are training-friendly. Population health dashboards, clinical decision support, MCP servers - layer them on top.

Timeline

A short company history.

2021

Reshma, Cody, and Rahul start Medplum in San Francisco.

The legal entity is Orangebot, Inc. The product is a FHIR-native developer platform that nobody asked for and many people needed.

2022 · SUMMER

Y Combinator S22.

Seed funding from the YC batch. Roughly $130k headline number.

2022 · NOVEMBER

Launch HN: "Open-Source Firebase for Healthcare."

The post hits the front page. The framing sticks.

2023 · APRIL

Grant funding round.

Non-dilutive money for a developer-tools company. Quiet but meaningful.

2024-2026

Adoption inside YC and beyond.

Healthtech founders default to Medplum. Hospital innovation teams begin self-hosting. The team grows to ~21.

Watch

Interviews & demos.

Both videos point at YouTube playlists for Medplum content and founder interviews.

Pages & Profiles

Where to find Medplum.

The Scene · Returned

Back to the coffee.What changed in the time it took to drink it.

The founder closes her laptop. The mug is empty. On her screen is a clinical workflow that, eighteen months ago, would have required a procurement committee, a vendor demo, and a contract with a multi-year escape clause. Instead, she has a fork. She has a license that lets her keep the fork. She has a hosted option if she wants someone else to handle the AWS bill, and a self-host option if she'd rather be the one paged at 3 a.m.

This is the strange, quiet thing about Medplum. It does not advertise itself as a revolution. It is too engineering-poker-faced for that. It just removes a step from a long list of steps - the step where you had to choose between owning your infrastructure and owning your time. Take that step away, and a lot of healthcare apps that previously couldn't exist begin to exist.

The coffee cup goes in the dishwasher. The patient portal goes into staging. Somewhere in a server, a FHIR resource is created. The plumbing works. The founder gets to think about something else.

Which was the point all along.

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