wound-healing
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The Boston Biotech Betting That Cells Don't Have to Show Up to Heal You
Aegle Therapeutics skips the stem cell transplant and ships only the message the cell was trying to send - a cell-free vesicle therapy now in human trials for one of the cruelest skin diseases in medicine.
PEDRA Technology
PEDRA Technology is a Singapore-based medical device company that built the PEDRA Xauron Perfusion System, the first device to deliver real-time, quantitative measurement of deep-tissue blood perfusion in the foot during vascular procedures. Aimed at physicians treating peripheral arterial disease (PAD) and critical limb threatening ischemia (CLTI), the laser-based, non-invasive system gives interventionalists objective feedback in the angio suite - where they have historically relied on subjective interpretation of X-ray images. The company raised a $4.7M Series A in 2020 and won FDA Breakthrough Device Designation in 2021.
Imagine Pharma
Imagine Pharma is a Pittsburgh biotechnology company built around IMG-1, a novel polypeptide its founder discovered in a tea plant from his native Vietnam. From that single molecule the company runs three platforms - Oral Delivery (making injectable biologics swallowable), Therapeutics, and Regenerative Medicine - with first-in-class programs aimed at curing type 1 diabetes, accelerating diabetic wound healing, and making injections obsolete. Alongside its pipeline, Imagine operates an NIH-approved islet isolation center that has completed dozens of clinical islet cell procedures for major U.S. hospital systems.