
From microRNA to engineered T cells to mitochondrial targets, the Austrian biochemist keeps returning to the same hard problem: how to carry a promising mechanism across the unruly distance between a lab result and a real company.
Josh Carle is the Chief Business Officer of Hinge Bio, a Burlingame, California biotech building multivalent, multispecific antibody therapies on its GEM-DIMER platform. A dealmaker by trade, he has led or advised more than fifty strategic transactions worth over $2 billion in disclosed deal value, moving from Pfizer Oncology and Daiichi Sankyo to immuno-oncology startup Triumvira before joining Hinge Bio in January 2023 to steer its lead lupus program toward the clinic.