transdermal
(2)
Novilla Pharmaceuticals
Novilla Pharmaceuticals is a Cambridge, Massachusetts biotech using a proprietary AI drug-delivery platform to redesign how established drugs reach the body. By pairing chemical-thermodynamic machine learning with deep eutectic solvents and ionic liquids, Novilla formulates non-invasive transdermal creams that concentrate a drug at its site of action while minimizing systemic exposure. Its lead candidate, NOV-1776 for gout flares, reported a 212% increase in efficacy over standard of care with under 1% systemic exposure and no GI adverse events in early human trials, positioning the company as a non-addictive alternative in pain care.
Shashi Kori
Shashi Kori is a neurologist and neuro-oncologist turned biotech founder, and the co-founder and CEO of Novilla Pharmaceuticals, a Cambridge-based company using a proprietary AI model to design transdermal formulations that deliver drugs to the site of action while minimizing systemic effects. Before Novilla, he spent decades building pain programs at Duke and the University of South Florida and led clinical development at GlaxoSmithKline, Allergan, MAP Pharmaceuticals and Autonomic Technologies. He partnered with Dr. Eric Fossel in 2019 to merge their drug-delivery innovations into Novilla's pipeline, led by lead candidate NOV-1776.