tead-inhibitor
(2)
Vivace Therapeutics, Inc.
Vivace Therapeutics is a San Mateo, California oncology company turning novel Hippo-YAP pathway biology into first-in-class cancer drugs. Its lead small molecule, VT3989, is a first-in-class YAP/TEAD inhibitor that blocks TEAD auto-palmitoylation and has shown durable responses in treatment-resistant mesothelioma and NF2-mutant tumors. Built on a capital-efficient US-China 'virtual biotech' model, the company has raised roughly $105 million across four rounds and is preparing a registrational Phase 3 trial.
Stephen Rubino
Stephen Rubino is the CEO of Sporos Bioventures, a Houston-based biotech that runs cancer drug development as a portfolio rather than a single bet. A Cornell-trained virologist with a Baruch MBA, he spent three decades in business development and commercial roles at Schering-Plough, Novartis, Celyad Oncology and Fortress Biotech before taking the helm at Sporos in 2022, where the lead program is SPR1, a next-generation TEAD inhibitor aimed at hard-to-drug cancers.