san-mateo-startup
(4)
Luminai
Luminai is an AI-native workflow automation platform built for the back office of American healthcare. It turns messy, unstructured inputs - faxes, chart notes, insurance forms - into structured data and then runs full administrative workflows like referral intake, patient registration, and denial appeals end to end, with a human in the loop and HIPAA/SOC 2 controls baked in. Founded in 2019 by Kesava Kirupa Dinakaran and Dmitry Dolgopolov, the company started life as customer-support RPA tool DigitalBrain, pivoted entirely into healthcare, and raised a $38M Series B in April 2026 led by Peak XV Partners, with Cleveland Clinic as a flagship partner.
Mendaera, Inc.
Mendaera is a Silicon Valley healthcare technology company building Focalist, a fist-sized handheld robotic system that pairs real-time ultrasound imaging with robotic needle guidance and AI to make precise, needle-based procedures more accessible across specialties. Founded in 2020 by Josh DeFonzo and Jason Wilson, both alumni of Auris Health, and backed by Intuitive Surgical and Auris co-founder Dr. Fred Moll, the company aims to move robotics beyond the operating room and into the everyday procedures that make up the bulk of medicine.
qikfox Cybersecurity Systems
qikfox Cybersecurity Systems is a San Mateo, California startup building what it calls the 'tool shed for a trustworthy Internet.' Founded in 2019 by serial entrepreneur Tarun Gaur after his mother lost money to an online scam, the company makes a privacy-first Smart Browser and Safe Search engine that deliver real-time scam and phishing protection, ad and tracker blocking, and biometric/PIN locks - without collecting browsing history or product analytics. qikfox claims to be the world's first browser to bake in both decentralized identity and quantum-resistant cryptography, and has since layered in an AI Copilot, 3D web, and knowledge-management features aimed at the emerging agentic web.
Eano
Eano is a San Mateo-based construction technology company building an all-in-one software platform for general contractors and remodelers. Started in 2019 by Stella Wu as a home-renovation services business, it pivoted into SaaS - Eano Pro - that bundles AI-powered estimates, proposals, CRM, payments, scheduling, and project management so small and mid-sized contractors can run more jobs without losing control of communication, budgets, or client experience.