ras-driven-cancers
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Quanta Therapeutics
Quanta Therapeutics is a clinical-stage biopharmaceutical company in South San Francisco building allosteric small-molecule inhibitors for RAS-driven cancers. Using a proprietary Second Harmonic Generation (SHG) optical platform that detects subtle changes in protein conformation, Quanta designs oral drugs aimed at KRAS mutations long considered undruggable - including G12D and G12V - that together drive a large share of pancreatic, colorectal, lung and endometrial cancers. Its lead candidate QTX3034 is in Phase 1 trials, with QTX3544 and a pan-KRAS program close behind.
Perry Nisen
Perry Nisen is a physician-scientist and CEO of Quanta Therapeutics, a South San Francisco biotech building next-generation oral KRAS inhibitors for RAS-driven cancers. A former pediatric oncologist turned pharma executive, he ran the GSK oncology portfolio later acquired by Novartis for over $16 billion, led the Sanford Burnham Prebys research institute, and serves on Teva's board. He now chases the 'undruggable' mutations that drive a quarter of all human cancers.