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biotech2 oncology2 gdf-152 visugromab2 monoclonal-antibody2 cachexia2 checkpoint-inhibitors2 munich2 series-d2 tumor-microenvironment2 immunotherapy1 cancer1 germany1 anti-pd-11

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CatalYm is a German clinical-stage biotech developing visugromab, a GDF-15 neutralizing monoclonal antibody designed to reverse immunotherapy resistance in solid tumors and address cancer cachexia.

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biotechoncologyimmunotherapygdf-15visugromabmonoclonal-antibody

PersonExecutiveOperator

Scott Clarke is the CEO of CatalYm GmbH, a Munich-based biotech company developing visugromab, a monoclonal antibody targeting GDF-15 to reverse cancer immunotherapy resistance. With over 20 years in biopharmaceuticals - spanning Roche's global oncology partnering, BioMarin, Tizona Therapeutics, and Ambagon Therapeutics - Clarke joined CatalYm in January 2025 to lead the company's $319M-funded push through Phase 2b clinical trials, building on visugromab's striking Phase 1/2a results published in Nature showing durable responses lasting 28-32+ months in multiple solid tumor types.

biotechceocancer-immunotherapygdf-15visugromaboncology