The IBM veterans behind Emergence AI want software agents to cross the messy borders between enterprise systems. Their own numbers explain both the opportunity and the catch: orchestration improved task success, but even the better system completed fewer than half the jobs in a company-run test.
Long before "conversational AI" was a phrase anyone Googled, Raj Koneru bet a company on the idea that people would rather talk to software than click through it. A decade and 450 Global 2000 customers later, Kore.ai is trying to prove enterprise AI agents can be trusted to actually do the work.
Synthpop is a Cambridge, Massachusetts healthcare AI company building agentic automation that eliminates administrative bottlenecks across payer, provider and patient operations. Its platform combines document intelligence, payer-aware reasoning and conversational voice agents into one coordinated system that automates as much as 80% of healthcare back-office processes - referrals, prior authorizations, eligibility checks and claims follow-ups - by integrating directly with EHR, billing and e-prescribe systems. Founded in 2023 by Elad Ferber and Jan Jannink, the company has raised $23M total, including a $15M Series A in February 2026.
Avataar is a Bengaluru- and San Francisco-based AI company that turns static product pages into 3D visuals, interactive experiences, and AI-generated videos for retailers and brands. Founded in 2014 by Sravanth Aluru and co-founders, it began with computer-vision-driven 3D product visualization for e-commerce and has since expanded into a full-stack agentic AI platform and its own distilled video model, Varya, positioned as a cheaper, culturally aware alternative to models like Veo and Runway. Backed by Tiger Global and Peak XV (formerly Sequoia Capital India), Avataar has raised roughly $55 million and counts HP, Victoria's Secret, Lowe's, and others among its customers.
Relevance AI is a platform for building and managing an AI workforce - teams of specialized AI agents that carry out real business work without human headcount. Founded in Sydney in 2020, the company lets operations teams, not just engineers, design multi-agent systems on a no-code canvas to run sales, marketing, research, support and back-office processes end to end. It raised a $24M Series B in May 2025 led by Bessemer Venture Partners, bringing total funding to roughly $37M, and counts Activision, Qualified and SafetyCulture among its customers.
RISA Labs is a Palo Alto healthtech company building an AI operating system for oncology. Its platform, BOSS (Business Operating System as a Service), decomposes the paperwork-heavy work of cancer care - prior authorization, benefits verification, eligibility checks, denial management - into micro-tasks handled by a network of AI agents, digital twins, and reinforcement learners that plug into EHRs and payer portals. Founded in 2024 by IIT Kanpur alumni Kshitij Jaggi and Kumar Shivang, RISA aims to cut the days-long administrative delays that keep cancer patients waiting for treatment.
Letta is a San Francisco AI research lab and platform for building stateful agents - AI that remembers, learns, and improves itself over time. Spun out of UC Berkeley's Sky Computing Lab from the viral MemGPT project, Letta gives developers an open framework, API, and cloud service where agent state (memories, messages, reasoning, tool calls) is persisted in a database rather than lost when it falls out of the context window. The company positions itself as the open alternative for developers who want to build agents that behave less like stateless chatbots and more like continuously learning digital collaborators.
Fundamental Research Labs (formerly Altera) is a San Francisco applied AI research company building autonomous, socially intelligent agents - what it calls 'digital human beings.' Founded by former MIT computational neuroscientist Dr. Robert Yang, the company ships consumer and prosumer products including Shortcut (a superhuman Excel agent) and Fairies (a general-purpose AI assistant), and raised a $33M Series A in August 2025 led by Prosus Ventures.
minds.ai builds AI systems for semiconductor manufacturers. Its Maestro platform - powered by the DeepSim engine - uses reinforcement learning, supervised learning, and generative AI to optimize fab scheduling, planning, forecasting, and control inside 24/7 wafer-fabrication plants. Founded in 2014, the company is based in Santa Cruz, California, with offices in Amsterdam and Bangalore.
VANTIQ is a Walnut Creek, California software company that builds a low-code platform for real-time, distributed, event-driven applications. The platform acts as a master orchestrator for agentic AI, generative AI, edge computing and IoT - letting enterprises sense events as they happen, reason over them with AI and multi-agent systems, and act in the moment for mission-critical outcomes across healthcare, defense, disaster response, manufacturing, energy and the public sector.
Mastra is an open-source TypeScript framework for building production-ready AI agents, workflows, and retrieval-augmented generation pipelines. Built by the team behind Gatsby, it gives developers agents, durable workflows, memory, RAG, tool calling, evals, and observability in one stack - so JavaScript and TypeScript engineers can move from prototype to production without leaving their language. Mastra is developed by Kepler Software, a San Francisco startup, and reached 25,000+ GitHub stars and 300,000+ weekly npm downloads with adoption at companies like Brex, Sanity, Replit, and PayPal.