metabolomics
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Olaris Spent 12 Years Turning a Cup of Urine Into an Early-Warning System for Kidney Transplants
The Boston-area biotech began with a sweeping promise to remove guesswork from medicine. Its first real wedge is narrower and more useful: a non-invasive test that helps clinicians decide when a transplanted kidney may need a closer look.
Calibra Scientific Inc.
Calibra Scientific Inc. (Hangzhou Calibra Diagnostics Co., Ltd., 凯莱谱) is a clinical mass spectrometry and multi-omics company that builds the full stack of precision diagnostics - instruments, reagent kits, reference materials and central-lab services. Founded in 2016 by Hua-fen Liu, a veteran of SCIEX, Roche and Pfizer, and backed as a DIAN Diagnostics company, Calibra has launched the NMPA-registered CalQuant-S mass spectrometry system, 10+ Class II reagent kits and 300+ clinical assays, serving more than 20,000 hospitals and research institutions across China.
Enveda
Enveda is a clinical-stage biotech that uses artificial intelligence to read the chemistry of the natural world and turn it into new medicines. Founded in 2019 by Viswa Colluru, the company built PRISM, a foundation model trained on more than a billion mass spectra, to decode the structure of natural molecules that traditional methods leave invisible. That platform has produced a pipeline of small-molecule drug candidates - led by ENV-294, an oral anti-inflammatory now in Phase 2 trials for atopic dermatitis and asthma. Backed by more than $700M in funding and valued as a unicorn, Enveda operates out of Boulder, Colorado and Hyderabad, India.
Matterworks
Matterworks is a Somerville, Massachusetts biotech-AI company building foundation models for molecular biology. Its Large Spectral Models (LSMs) are trained on billions of mass spectrometry spectra and read raw molecular signals directly, turning slow, manual mass-spec workflows into automated, untargeted absolute quantitation. Its flagship cloud platform, Pyxis, acts as a predictive omics assistant that converts raw LC-MS data into identified, quantified molecules and biological insight - making mass spectrometry usable by any biologist rather than only specialist analysts.
Newomics, Inc.
Newomics is a Berkeley, California biotechnology company building mass spectrometry front-end hardware for precision medicine. Spun out of Lawrence Berkeley National Laboratory, its silicon multinozzle emitter (M3) and MnESI ion source upgrade existing mass spectrometers to deliver microflow robustness with nanospray sensitivity, enabling higher-throughput, higher-sensitivity multiomics across proteomics, metabolomics, lipidomics, native MS and single-cell analysis. The company sells to pharmaceutical, academic and government labs and co-markets with major instrument vendors like Thermo Fisher Scientific.